Search Results - "Ward, T.H"

Noninvasive fluorescence imaging of small animals by ZELMER, A., WARD, T.H.

“…Summary Noninvasive in vivo fluorescence imaging of small animals as a method in preclinical research has developed considerably in recent years, and is used…”
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DT-diaphorase: a target for new anticancer drugs by Danson, S, Ward, T.H, Butler, J, Ranson, M

“…DT-diaphorase (DTD) is an obligate two-electron reductase which bioactivates chemotherapeutic quinones. DTD levels are elevated in a number of tumour types,…”
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Validation of an ELISA for the determination of rituximab pharmacokinetics in clinical trials subjects by Hampson, G., Ward, T.H., Cummings, J., Bayne, M., Tutt, A.L., Cragg, M.S., Dive, C., Illidge, T.M.

“…Rituximab is a chimeric anti-CD20 monoclonal antibody that has revolutionised the treatment of many B-cell malignancies, and is now increasingly being used in…”
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102 POSTER Quantitative clinical biomarker measurement using multiplexed quantum dot immunhistochemistry by Sweeney, E, Ward, T.H, Gray, N, Womack, C, Jayson, G, Hughes, A, Dive, C, Byers, R

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Quantitative multiplexed quantum dot immunohistochemistry by Sweeney, E., Ward, T.H., Gray, N., Womack, C., Jayson, G., Hughes, A., Dive, C., Byers, R.

“…Quantum dots are photostable fluorescent semiconductor nanocrystals possessing wide excitation and bright narrow, symmetrical, emission spectra. These…”
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Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1 by Danson, S.J., Johnson, P., Ward, T.H., Dawson, M., Denneny, O., Dickinson, G., Aarons, L., Watson, A., Jowle, D., Cummings, J., Robson, L., Halbert, G., Dive, C., Ranson, M.

“…This trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours. A…”
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‘Fit-for-purpose’ validation of SearchLight multiplex ELISAs of angiogenesis for clinical trial use by Backen, A.C., Cummings, J., Mitchell, C., Jayson, G., Ward, T.H., Dive, C.

“…Validated assays of circulating biomarkers of angiogenesis to predict and determine the efficacy of vascular-targeted anticancer drugs would facilitate…”
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Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA by Navasumrit, P, Ward, T H, O'Connor, P J, Nair, J, Frank, N, Bartsch, H

“…To investigate the role of ethanol in chemically-induced carcinogenesis, we exposed Wistar rats to ethanol, either as an acute dose or for prolonged periods in…”
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Electrochemical Monitoring of Anticancer Compounds on the Human Ovarian Carcinoma Cell Line A2780 and Its Adriamycin- and Cisplatin-Resistant Variants by Woolley, D.E., Tetlow, L.C., Adlam, D.J., Gearey, D., Eden, R.D., Ward, T.H., Allen, T.D.

“…A novel electrochemical technique which detects and monitors real-time changes in cell behavior in vitro has been used to examine the effects of recognized…”
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143 POSTER Comparison of cell death ELISAs applied as potential surrogate biomarkers in the clinical evalution of AEG35156 (XIAP antisense) by Cummings, J., Ward, T.H., Ranson, M., Smith, N.K., Jodrell, D., Robson, L., Dean, E., Dive, C.

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469 POSTER Detection of surrogate markers of apoptosis in the peripheral blood of a preclinical tumour model treated with a selective inhibitor of Aurora B kinase (AZD1152) by Wilkinson, R.W., Odedra, R., Heaton, S.P., Crafter, C., Growcott, J., Mundt, K., Cummings, J., Ward, T.H., Hegarty, C., Dive, C.

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135 The effect of STI 571 on deoxycytidine kinase activity in head and neck squamous cell carcinoma in vitro: clinical implications by Bruce, I., Ward, T.H., Homer, J.J., Slevin, N.J.

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Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation by Kim, Joo-Young, West, C.M.L., Valentine, H., Ward, T.H., Patterson, A.V., Stratford, I.J., Roberts, S.A., Hendry, J.H.

“…RH1 is a new bioreductive agent that was developed as a cytotoxic agent with selectivity for tumour cells expressing high levels of the enzyme DT-diaphorase…”
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494 Preliminary results from a phase I clinical trial of the bioreductive drug, RH1 by Ward, T.H., Danson, S., Dawson, M., Denneny, O., McGrath, H., Cummings, J., Johnson, P., Dive, C., Ranson, M.

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453 Validation of pharmacodynamic assays to determine the clinical effect of an antisense to the XIAP inhibitor of apoptosis by Cummings, J., Ward, T.H., LaCasse, E., Lefebvre, C., St.-Jean, M., Dawson, M., Durkin, J., Ranson, M., Dive, C.

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Measurements of photomultiplier single photon counting efficiency for the Sudbury Neutrino Observatory by Biller, S.D, Jelley, N.A, Thorman, M.D, Fox, N.P, Ward, T.H

“…A knowledge of the absolute efficiency of the photomultiplier tubes (PMTs) used in the Sudbury Neutrino Observatory (SNO) is important for modelling the…”
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Upregulation of O6-alkylguanine-DNA-alkyltransferase expression and the presence of double minute chromosomes in alkylating agent selected Chinese hamster cells by Morten, J E, Bayley, L, Watson, A J, Ward, T H, Potter, P M, Rafferty, J A, Margison, G P

“…Chinese hamster V79 lung fibroblasts are sensitive to the toxic effects of chloroethylating agents such as mitozolomide (Mz) and express very low levels (less…”
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The lack of correlation between toxicity and free radical formation of two diaziridinyl benzoquinones by Lea, J S, Garner, H J, Butler, J, Hoey, B M, Ward, T H

“…L1210 and K562 leukaemic cells have been used to study the relationship between cytotoxicity and free radical production by two aziridinyl benzoquinones,…”
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A limited international intercomparison of responsivity scales at fiber optic wavelengths by GALLAWA, R. L, GARDNER, J. L, NETTLETON, D. H, STOCK, K. D, WARD, T. H, XIAOYU LI

“…We report here on a recent limited international intercomparison of responsivity scales at wavelengths of interest to the optical communications community…”
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