Search Results - "Ward, Stephen A"

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 by Ismail, Hanafy M., Barton, Victoria, Phanchana, Matthew, Charoensutthivarakul, Sitthivut, Wong, Michael H. L., Hemingway, Janet, Biagini, Giancarlo A., O’Neill, Paul M., Ward, Stephen A.

“…The artemisinin (ART)-based antimalarials have contributed significantly to reducing global malaria deaths over the past decade, but we still do not know how…”
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The molecular mechanism of action of artemisinin--the debate continues by O'Neill, Paul M, Barton, Victoria E, Ward, Stephen A

“…Despite international efforts to 'roll back malaria' the 2008 World Malaria Report revealed the disease still affects approximately 3 billion people in 109…”
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Antimalarial activity of primaquine operates via a two-step biochemical relay by Camarda, Grazia, Jirawatcharadech, Piyaporn, Priestley, Richard S., Saif, Ahmed, March, Sandra, Wong, Michael H. L., Leung, Suet, Miller, Alex B., Baker, David A., Alano, Pietro, Paine, Mark J. I., Bhatia, Sangeeta N., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

“…Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70 years ago, its mode of action is unclear. Here, we demonstrate that…”
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Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis by Taylor, Mark J, Hoerauf, Achim, Townson, Simon, Slatko, Barton E, Ward, Stephen A

“…Anti-Wolbachia therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the…”
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Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential by Antoine, Thomas, Fisher, Nicholas, Amewu, Richard, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

“…Objectives Artemisinin and artemisinin semi-synthetic derivatives (collectively known as endoperoxides) are first-line antimalarials for the treatment of…”
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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 by Capper, Michael J, O'Neill, Paul M, Fisher, Nicholas, Strange, Richard W, Moss, Darren, Ward, Stephen A, Berry, Neil G, Lawrenson, Alexandre S, Hasnain, S Samar, Biagini, Giancarlo A, Antonyuk, Svetlana V

“…Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism…”
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M1 macrophage features in severe Plasmodium falciparum malaria patients with pulmonary oedema by Klinkhamhom, Aekkarin, Glaharn, Supattra, Srisook, Charit, Ampawong, Sumate, Krudsood, Srivicha, Ward, Stephen A, Viriyavejakul, Parnpen

“…Pulmonary oedema (PE) is a serious complication of Plasmodium falciparum malaria which can lead to acute lung injury in severe cases. Lung macrophages are…”
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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides by Clare, Rachel H., Bardelle, Catherine, Harper, Paul, Hong, W. David, Börjesson, Ulf, Johnston, Kelly L., Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A. N., Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L., Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G., O’Neill, Paul M., Taylor, Mark J., Ward, Stephen A.

“…Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia , for survival and fecundity, making Wolbachia a…”
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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria by Biagini, Giancarlo A, Fisher, Nicholas, Shone, Alison E, Mubaraki, Murad A, Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A, Nixon, Gemma L, Chadwick, James, Hemingway, Janet, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H. M, Berry, Neil G, O’Neill, Paul M, Ward, Stephen A

“…There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance…”
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Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis by Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.

“…Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial…”
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Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration by Aljayyoussi, Ghaith, Jenkins, Victoria A., Sharma, Raman, Ardrey, Alison, Donnellan, Samantha, Ward, Stephen A., Biagini, Giancarlo A.

“…Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs taken for 6 months. Improved drug regimens to shorten and simplify…”
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Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins by O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A

“…Fighting drug resistence: From a library of over 150 1,2,4,5‐tetraoxanes, the candidate RKA 182 was selected for preclinical development as an antimalarial…”
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Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc1 Catalytic Turnover and Protein Expression by Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley J., Johnson, David J., Lawrenson, Alexandre S., Ranson, Hilary, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

“…Atovaquone is an anti-malarial drug used in combination with proguanil (e.g. MalaroneTM) for the curative and prophylactic treatment of malaria. Atovaquone, a…”
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Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) by Pidathala, Chandrakala, Amewu, Richard, Pacorel, Bénédicte, Nixon, Gemma L, Gibbons, Peter, Hong, W. David, Leung, Suet C, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M

“…A program was undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a dehydrogenase of the mitochondrial electron transport…”
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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae by Hübner, Marc P, Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J, Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W, Marsh, Kennan, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A, Pfarr, Kenneth, Kempf, Dale J, Hoerauf, Achim

“…Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult…”
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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity by von Geldern, Thomas W, Morton, Howard E, Clark, Rick F, Brown, Brian S, Johnston, Kelly L, Ford, Louise, Specht, Sabine, Carr, Robert A, Stolarik, Deanne F, Ma, Junli, Rieser, Matthew J, Struever, Dominique, Frohberger, Stefan J, Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D, Hübner, Marc P, Hoerauf, Achim, Taylor, Mark J, Ward, Stephen A, Marsh, Kennan, Kempf, Dale J

“…There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an…”
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Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance by Ward, Stephen A, Prof, Sevene, Esperanca JP, MD, Hastings, Ian M, PhD, Nosten, François, Prof, McGready, Rose, MD

“…Summary Before a recommendation for antimalarial drug use in pregnancy is made, it is essential that we understand the potential risks involved and have…”
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Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models by Sjoberg, Hanna T, Pionnier, Nicolas, Aljayyoussi, Ghaith, Metuge, Haelly M, Njouendou, Abdel J, Chunda, Valerine C, Fombad, Fanny F, Tayong, Dizzle B, Gandjui, Narcisse V T, Akumtoh, Desmond N, Chounna, Patrick W N, Ndzeshang, Bertrand L, Lachaud, Sophie, Tekle, Fetene, Quirynen, Ludo, Engelen, Marc, Baeten, Benny, Steven, Andrew, Ward, Stephen A, Taylor, Mark J, Wanji, Samuel, Turner, Joseph D

“…The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure…”
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Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome bc1 Complex for the Development of Next Generation Quinolone Antimalarials by Amporndanai, Kangsa, Pinthong, Nattapon, O’Neill, Paul M., Hong, W. David, Amewu, Richard K., Pidathala, Chandrakala, Berry, Neil G., Leung, Suet C., Ward, Stephen A., Biagini, Giancarlo A., Hasnain, S. Samar, Antonyuk, Svetlana V.

“…Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the…”
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Pharmacokinetics of Rifampin in Peruvian Tuberculosis Patients with and without Comorbid Diabetes or HIV by Requena-Méndez, Ana, Davies, Geraint, Ardrey, Alison, Jave, Oswaldo, López-Romero, Sonia L, Ward, Stephen A, Moore, David A. J

“…For drug-compliant patients, poor responses to tuberculosis (TB) treatment might be attributable to subtherapeutic drug concentrations. An impaired absorption…”
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