Search Results - "Ward, Sean M."

Nitric oxide and its role as a non‐adrenergic, non‐cholinergic inhibitory neurotransmitter in the gastrointestinal tract by Sanders, Kenton M, Ward, Sean M

“…NO is a neurotransmitter released from enteric inhibitory neurons and responsible for modulating gastrointestinal (GI) motor behaviour. Enteric neurons express…”
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Interstitial cells: regulators of smooth muscle function by Sanders, Kenton M, Ward, Sean M, Koh, Sang Don

“…Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells. Interstitial cells of mesenchymal origin interact with and form…”
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Regulation of gastrointestinal motility—insights from smooth muscle biology by Sanders, Kenton M., Koh, Sang Don, Ro, Seungil, Ward, Sean M.

“…Gastrointestinal motility results from coordinated contractions of the smooth muscle tissues forming the tunica muscularis of the alimentary canal. Smooth…”
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Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport by Yuan, Shuiqiao, Wang, Zhuqing, Peng, Hongying, Ward, Sean M., Hennig, Grant W., Zheng, Huili, Yan, Wei

“…Mammalian oviducts play an essential role in female fertility by picking up ovulated oocytes and transporting and nurturing gametes (sperm/oocytes) and early…”
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Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells by Sanders, Kenton M, Kito, Yoshihiko, Hwang, Sung Jin, Ward, Sean M

“…Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In…”
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A functional role for the ‘fibroblast‐like cells’ in gastrointestinal smooth muscles by Kurahashi, Masaaki, Zheng, Haifeng, Dwyer, Laura, Ward, Sean M., Don Koh, Sang, Sanders, Kenton M.

“…Non‐technical summary Smooth muscles, as in the gastrointestinal tract, are composed of several types of cells. Gastrointestinal muscles contain smooth muscle…”
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The Mystery of the Interstitial Cells in the Urinary Bladder by Koh, Sang Don, Lee, Haeyeong, Ward, Sean M, Sanders, Kenton M

“…Intrinsic mechanisms to restrain smooth muscle excitability are present in the bladder, and premature contractions during filling indicate a pathological…”
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Effects of new‐generation inhibitors of the calcium‐activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract by Hwang, Sung Jin, Basma, Naseer, Sanders, Kenton M, Ward, Sean M

“…Background and Purpose High‐throughput screening of compound libraries using genetically encoded fluorescent biosensors has identified several…”
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Neuroeffector apparatus in gastrointestinal smooth muscle organs by Sanders, Kenton M., Hwang, Sung Jin, Ward, Sean M.

“…Control of gastrointestinal (GI) movements by enteric motoneurons is critical for orderly processing of food, absorption of nutrients and elimination of…”
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Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures by Lee, Moon Young, Ha, Se Eun, Park, Chanjae, Park, Paul J, Fuchs, Robert, Wei, Lai, Jorgensen, Brian G, Redelman, Doug, Ward, Sean M, Sanders, Kenton M, Ro, Seungil

“…Transcriptome-scale data can reveal essential clues into understanding the underlying molecular mechanisms behind specific cellular functions and biological…”
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Identification and classification of interstitial cells in the mouse renal pelvis by Grainger, Nathan, Freeman, Ryan S., Shonnard, Cameron C., Drumm, Bernard T., Koh, Sang Don, Ward, Sean M., Sanders, Kenton M.

“…Key points Platelet‐derived growth factor receptor‐α (PDGFRα) is a novel biomarker along with smooth myosin heavy chain for the pacemaker cells (previously…”
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A Ca2+‐activated Cl− conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity by Zhu, Mei Hong, Kim, Tae Wan, Ro, Seungil, Yan, Wei, Ward, Sean M., Koh, Sang Don, Sanders, Kenton M.

“…Interstitial cells of Cajal (ICC) are unique cells that generate electrical pacemaker activity in gastrointestinal (GI) muscles. Many previous studies have…”
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Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation by Martín-Aragón Baudel, Miguel, Flores-Tamez, Victor A., Hong, Junyoung, Reddy, Gopyreddy R., Maillard, Pauline, Burns, Abby E., Man, Kwun Nok Mimi, Sasse, Kent C., Ward, Sean M., Catterall, William A., Bers, Donald M., Hell, Johannes W., Nieves-Cintrón, Madeline, Navedo, Manuel F.

“…BACKGROUNDL-type CaV1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. This study tests the hypothesis that…”
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Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles by Hwang, Sung Jin, Blair, Peter J. A., Britton, Fiona C., O’Driscoll, Kate E., Hennig, Grant, Bayguinov, Yulia R., Rock, Jason R., Harfe, Brian D., Sanders, Kenton M., Ward, Sean M.

“…Interstitial cells of Cajal (ICC) generate pacemaker activity (slow waves) in gastrointestinal (GI) smooth muscles, but the mechanism(s) of pacemaker activity…”
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Temporal sequence of activation of cells involved in purinergic neurotransmission in the colon by Baker, Salah A., Hennig, Grant W., Ward, Sean M., Sanders, Kenton M.

“…Key points Platelet derived growth factor receptor α (PDGFRα+) cells in colonic muscles are innervated by enteric inhibitory motor neurons. PDGFRα+ cells…”
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Relationships of endocrine cells to each other and to other cell types in the human gastric fundus and corpus by Fakhry, Josiane, Stebbing, Martin J., Hunne, Billie, Bayguinov, Yulia, Ward, Sean M., Sasse, Kent C., Callaghan, Brid, McQuade, Rachel M., Furness, John B.

“…Gastric endocrine cell hormones contribute to the control of the stomach and to signalling to the brain. In other gut regions, enteroendocrine cells (EECs)…”
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Interstitial cells of cajal as pacemakers in the gastrointestinal tract by Sanders, Kenton M, Koh, Sang Don, Ward, Sean M

“…In the gastrointestinal tract, phasic contractions are caused by electrical activity termed slow waves. Slow waves are generated and actively propagated by…”
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The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach by Sung, Tae Sik, Hwang, Sung Jin, Koh, Sang Don, Bayguinov, Yulia, Peri, Lauen E., Blair, Peter J., Webb, Timothy I., Pardo, David M., Rock, Jason R., Sanders, Kenton M., Ward, Sean M.

“…Key points Enteric neurotransmission is essential for gastrointestinal (GI) motility, although the cells and conductances responsible for post‐junctional…”
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Involvement of intramuscular interstitial cells of Cajal in neuroeffector transmission in the gastrointestinal tract by Ward, Sean M., Sanders, Kenton M.

“…Specialized cells known as interstitial cells of Cajal (ICC) are distributed in specific locations within the tunica muscularis of the gastrointestinal (GI)…”
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Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy by Moon, Suk Bae, Hwang, Sung Jin, Baker, Sal, Kim, Minkyung, Sasse, Kent, Koh, Sang Don, Sanders, Kenton M, Ward, Sean M

“…Obesity is a critical risk factor of several life-threatening diseases and the prevalence in adults has dramatically increased over the past ten years. In the…”
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