Search Results - "Ward, Robert W."

5-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) by Witherington, Jason, Bordas, Vincent, Garland, Stephen L, Hickey, Deirdre M.B, Ife, Robert J, Liddle, John, Saunders, Martin, Smith, David G, Ward, Robert W

“…A novel series of pyrazolo[3,4- b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3). A novel series of…”
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6-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) by Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Garton, Neil S., Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.

“…A novel series of 6-aryl-pyrazolo[3,4- b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3). Utilising X-ray…”
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3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) by Smith, David G., Buffet, Marianne, Fenwick, Ashley E., Haigh, David, Ife, Robert J., Saunders, Martin, Slingsby, Brian P., Stacey, Rachel, Ward, Robert W.

“…Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are…”
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6-Heteroaryl-pyrazolo[3,4- b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) by Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.

“…A series of 6-heteroaryl-pyrazolo[3,4- b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues…”
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The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement by Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

“…A series of α7 nicotinic acetylcholine receptor full agonists with a 1,3,4-oxadiazol-2-amine core has been discovered. Early lead 1 was found to have a limited…”
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Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition by Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

“…A series of α7 nicotinic acetylcholine receptor full-agonists with a 1,3,4-oxadiazol-2-amine core has been discovered. Systematic exploration of the…”
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Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor by Witherington, Jason, Abberley, Lee, Bellenie, Benjamin R., Boatman, Rio, Collis, Katharine, Dean, David K., Gaiba, Alessandra, Paul King, N., Shuker, Nicola, Steadman, Jon G.A., Takle, Andrew K., Sanger, Gareth, Butler, Sharon, McKay, Fiona, Muir, Alison, Winborn, Kim, Ward, Robert W., Heightman, Tom D.

“…As part of an on-going lead optimisation effort, a cross screening exercise identified an aryl sulphonyl amide hit that was optimised to afford a highly potent…”
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Pyridone derivatives as potent and selective VLA-4 integrin antagonists by Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Green, Phil M., Naylor, Antoinette, Parr, Nigel, Smith, David G., Takle, Andrew K., Ward, Robert W.

“…Employing molecular overlay studies of our initial leads with known VLA-4 antagonists has led to the hypothesis of a novel pharmacophore. Subsequent design and…”
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Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists by Witherington, Jason, Blaney, Emma L., Bordas, Vincent, Elliott, Richard L., Gaiba, Alessandra, Garton, Neil, Green, Philip M., Naylor, Antoinette, Smith, David G., Spalding, David J., Takle, Andrew K., Ward, Robert W.

“…Systematic optimisation of a previously described series of novel VLA-4 antagonists has identified a potent orally bioavailable VLA-4 integrin antagonist. A…”
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5-Aryl-pyrazolo[3,4- b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) by Witherington, Jason, Bordas, Vincent, Haigh, David, Hickey, Deirdre M.B, Ife, Robert J, Rawlings, Anthony D, Slingsby, Brian P, Smith, David G, Ward, Robert W

“…Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4- b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition…”
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Synthesis of novel N-phosphonoalkyl dipeptide inhibitors of human collagenase by Bird, John, De Mello, Rachel C, Harper, Gregory P, Hunter, David J, Karran, Eric H, Markwell, Roger E, Miles-Williams, Anette J, Rahman, Shahzad S, Ward, Robert W

“…The synthesis of a series of N-phosphonalkyl dipeptides 6 is described. Syntheses were devised that allowed the preparation of single diastereoisomers and the…”
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Rats and mice and animal feed – a risk too far? by Hurst, Jane L, Ward, W Robert

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Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription by Coghlan, Matthew P, Culbert, Ainsley A, Cross, Darren AE, Corcoran, Stacey L, Yates, John W, Pearce, Nigel J, Rausch, Oliver L, Murphy, Gregory J, Carter, Paul S, Roxbee Cox, Lynne, Mills, David, Brown, Murray J, Haigh, David, Ward, Robert W, Smith, David G, Murray, Kenneth J, Reith, Alastair D, Holder, Julie C

“…Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli…”
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A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine by Sharp, Michelle, Burkart, Kristin M., Adelman, Mark H., Ashton, Rendell W., Daugherty Biddison, Lee, Bosslet, Gabriel T., Doyle, Stephen T., Eckmann, Thomas, Khurram S. Khan, Malik M., Lenz, Peter H., McCallister, Jennifer W., O’Toole, Jacqueline, Rand, Cynthia S., Riekert, Kristin A., Soffler, Morgan I., Winter, Gretchen R., Zaeh, Sandra, Eakin, Michelle N., Arabelovic, Senada, Baer, Alan, Greene, Jerome L., Baker, Matthew C., Bloch, Donald, Cohen, Philip, Danielides, Stamatina J., Danila, Maria, Dellaripa, Paul F., Lawrence Ford, Theresa, Fox, Robert I., Grader-Beck, Thomas, Johr, Chadwick R., Kassan, Stuart, Katsumoto, Tamiko, Kontzias, Apostolos, Koons, Kirsten, Kyttaris, Vasileios C., Lewis, Janet, Lieberman, Scott M., McCoy, Sara S., Niewold, Timothy, Noaiseh, Ghaith, Osborn, Thomas G., Culpepper Pace, Schartess, Peredo-Wende, Ruben, Pillemer, Stanley, Neal Roberts, W., Rosenstein, Elliot, Sachdev, Amit, Sandorfi, Nora, Segal, Barbara, Siva, Chokkalingam, Small, Daniel, Spiera, Robert F., Topilow, James, Treadwell, Edward L., Vivino, Frederick B., Volkmann, Elizabeth, Wallace, Daniel J., Zashin, Scott, Gupta Argula, Rahul, Barney, Joseph, Burger, Charles D., Downey, Gregory P., Gagermeier, James, Helmers, Richard A., Hewlett, Justin C., Keith, Rebecca C., Koslow, Matthew, Kotloff, Robert, Krishna, Rachana, Luckhardt, Tracy R., Robinson, Keith, Ryu, Jay H., Shifren, Adrian, Staton, Gerald, Swigris, Jeff, Vassallo, Robert, Veraldi, Kristen L., Ward, Robert W., Bromet, Evelyn J., Dale, Jeanne, Furlong, Judith A., Neall, Kerry L., Petruzzi, Lynn M., Schafer, Sarah, Kukla, Heidi

“…The prevalence of burnout and depressive symptoms is high among physician trainees. What is the burden of burnout and depressive symptoms among fellows…”
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Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase by Jones, Terence R, Varney, Michael D, Webber, Stephen E, Lewis, Kathleen K, Marzoni, Gifford P, Palmer, Cindy L, Kathardekar, Vinit, Welsh, Katharine M, Webber, Stephanie, Matthews, David A, Appelt, Krzysztof, Smith, Ward W, Janson, Cheryl A, Villafranca, J. E, Bacquet, Russell J, Howland, Eleanor F, Booth, Carol L. J, Herrmann, Steven M, Ward, Robert W, White, Jennifer, Moomaw, Ellen W, Bartlett, Charlotte A, Morse, Cathy A

“…To develop novel lipophilic thymidylate synthase (TS) inhibitors, the X-ray structure of Escherichia coli TS in ternary complex with FdUMP and the inhibitor…”
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Assessment of Unpublished Scholarly Activity: An Informal Rubric for Evaluating Faculty Performance by Ward, Robert W.

“…Some forms of scholarly productivity, such as peer-reviewed publications, are easily recognized and incorporated into processes involving evaluation,…”
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Separate and Distinct: A Comparison of Scholarly Productivity, Teaching Load, and Compensation of Chiropractic Teaching Faculty to Other Sectors of Higher Education by Ward, Robert W.

“…Background: Faculty scholarship, teaching load, and compensation can be indicators of institutional health and can impact curricular quality. Periodic data are…”
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Novel products arising from bisarylmaleimide synthesis by Garton, Neil S., Ward, Robert W., Copley, Royston C.B.

“…The reaction of a 2-methoxyarylglyoxalate with a 2,3,6-trifluorophenylacetamide yielded a novel 2-hydroxyaryl substituted bisarylmaleimide. The reaction of a…”
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The discovery of 2-fluoro-N-3-fluoro-4-5-((4-morpholinobutyl)amino)-1,3, 4-oxadiazol-2-ylphenylbenzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement by SKIDMORE, John, ATCHA, Zeenat, HURST, David N, JAVED, Sahar, MARTIN, Samuel, MASKELL, Emma S. L, NORTON, David, PEMBERTON, Darrel J, REDSHAW, Sally, RUTTER, Richard, SEHMI, Sanjeet S, SCOCCITTI, Tiziana, BOUCHERAT, Emmanuelle, TEMPLE, Hannah E, THEOBALD, Pam, WARD, Robert W, WILSON, David M, CASTELLETTI, Laura, CHEN, Deborah W, COPPO, Frank T, CUTLER, Leanne, DUNSDON, Rachel M, HEATH, Bronagh M, HUTCHINGS, Rio

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7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents by Boyle, Elizabeth A, Mangan, Frank R, Markwell, Roger E, Smith, Stephen A, Thomson, Michael J, Ward, Robert W, Wyman, Paul A

“…The synthesis of a series of 7-aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids is described…”
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