Search Results - "Ward, Malcolm A."

Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis by Hanger, Diane P., Byers, Helen L., Wray, Selina, Leung, Kit-Yi, Saxton, Malcolm J., Seereeram, Anjan, Reynolds, C. Hugh, Ward, Malcolm A., Anderton, Brian H.

“…Tau in Alzheimer disease brain is highly phosphorylated and aggregated into paired helical filaments comprising characteristic neurofibrillary tangles. Here we…”
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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes by Grant, Seth G. N, Husi, Holger, Ward, Malcolm A, Choudhary, Jyoti S, Blackstock, Walter P

“…N-methyl-d-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength via downstream signaling pathways. We report proteomic characterization…”
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Comparison of Cellular Ribonucleoprotein Complexes Associated with the APOBEC3F and APOBEC3G Antiviral Proteins by GALLOIS-MONTBRUN, Sarah, HOLMES, Rebecca K, SWANSON, Chad M, FERNANDEZ-OCANA, Mireia, BYERS, Helen L, WARD, Malcolm A, MALIM, Michael H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion by Eaton, Philip, Byers, Helen L., Leeds, Nicola, Ward, Malcolm A., Shattock, Michael J.

“…We have developed methods that allow detection, quantitation, purification, and identification of cardiac proteinsS-thiolated during ischemia and reperfusion…”
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Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn by Scales, Timothy Me, Derkinderen, Pascal, Leung, Kit-Yi, Byers, Helen L, Ward, Malcolm A, Price, Caroline, Bird, Ian N, Perera, Timothy, Kellie, Stuart, Williamson, Ritchie, Anderton, Brian H, Reynolds, C Hugh

“…Tau protein is the principal component of the neurofibrillary tangles found in Alzheimer's disease, where it is hyperphosphorylated on serine and threonine…”
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Identification and Functional Characterization of Cytoplasmic Determinants of Plasmid DNA Nuclear Import by Munkonge, Felix M., Amin, Vaksha, Hyde, Stephen C., Green, Anne-Marie, Pringle, Ian A., Gill, Deborah R., Smith, Joel W.S., Hooley, Robert P., Xenariou, Stefania, Ward, Malcolm A., Leeds, Nicola, Leung, Kit-Yi, Chan, Mario, Hillery, Elizabeth, Geddes, Duncan M., Griesenbach, Uta, Postel, Edith H., Dean, David A., Dunn, Michael J., Alton, Eric W.F.W.

“…Import of exogenous plasmid DNA (pDNA) into mammalian cell nuclei represents a key intracellular obstacle to efficient non-viral gene delivery. This includes…”
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Proteomics Characterization of Abundant Golgi Membrane Proteins by Bell, Alexander W., Ward, Malcolm A., Blackstock, Walter P., Freeman, Hamzah N.M., Choudhary, Jyoti S., Lewis, Alan P., Chotai, Dipti, Fazel, Ali, Gushue, Jennifer N., Paiement, Jacques, Palcy, Sandrine, Chevet, Eric, Lafrenière-Roula, Myriam, Solari, Roberto, Thomas, David Y., Rowley, Adele, Bergeron, John J.M.

“…A mass spectrometric analysis of proteins partitioning into Triton X-114 from purified hepatic Golgi apparatus (84% purity by morphometry, 122-fold enrichment…”
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Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring by Byers, Helen L., Campbell, James, van Ulsen, Peter, Tommassen, Jan, Ward, Malcolm A., Schulz-Knappe, Peter, Prinz, Thorsten, Kuhn, Karsten

“…Tandem Mass Tags (TMT) are suited to both global and targeted quantitation approaches of proteins and peptides. Different versions of these tags allow for the…”
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Purification and identification of the STAT5 protease in myeloid cells by Schuster, Björn, Hendry, Lisa, Byers, Helen, Lynham, Steven F, Ward, Malcolm A, John, Susan

“…STAT (signal transducer and activator of transcription) proteins are critical regulators of cytokine-induced cell proliferation, differentiation and survival…”
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Combined tissue and fluid proteomics with Tandem Mass Tags to identify low‐abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study by Russell, Claire L., Heslegrave, Amanda, Mitra, Vikram, Zetterberg, Henrik, Pocock, Jennifer M., Ward, Malcolm A., Pike, Ian

“…Rationale Ideal biomarkers are present in readily accessible samples including plasma and cerebrospinal fluid (CSF), and are directly derived from diseased…”
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Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin by Cuchillo-Ibanez, Inmaculada, Seereeram, Anjan, Byers, Helen L, Leung, Kit-Yi, Ward, Malcolm A, Anderton, Brian H, Hanger, Diane P

“…Defective axonal transport has been proposed as an underlying mechanism that may give rise to neurodegeneration. We investigated the effect of phosphorylation…”
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Post-translational modifications in Alzheimer's disease and the potential for new biomarkers by Russell, Claire L, Koncarevic, Sasa, Ward, Malcolm A

“…The ability to detect and diagnose Alzheimer's disease (AD) early is an ever pressing issue, and the development of markers of disease progression that are…”
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A novel strategy using MASCOT Distiller for analysis of cleavable isotope-coded affinity tag data to quantify protein changes in plasma by Leung, Kit-Yi, Lescuyer, Pierre, Campbell, James, Byers, Helen L., Allard, Laure, Sanchez, Jean-Charles, Ward, Malcolm A.

“…A novel strategy consisting of cleavable Isotope‐Coded Affinity Tag (cICAT) combined with MASCOT Distiller was evaluated as a tool for the quantification of…”
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Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease by Güntert, Andreas, Campbell, James, Saleem, Muzamil, O'Brien, Darragh P, Thompson, Andrew J, Byers, Helen L, Ward, Malcolm A, Lovestone, Simon

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder where definite diagnosis can only be made postmortem, and for which the most promising…”
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Tyrosine 394 Is Phosphorylated in Alzheimer's Paired Helical Filament Tau and in Fetal Tau with c-Abl as the Candidate Tyrosine Kinase by Derkinderen, Pascal, Scales, Timothy M. E, Hanger, Diane P, Leung, Kit-Yi, Byers, Helen L, Ward, Malcolm A, Lenz, Christof, Price, Caroline, Bird, Ian N, Perera, Timothy, Kellie, Stuart, Williamson, Ritchie, Noble, Wendy, Van Etten, Richard A, Leroy, Karelle, Brion, Jean-Pierre, Reynolds, C. Hugh, Anderton, Brian H

“…Tau is a major microtubule-associated protein of axons and is also the principal component of the paired helical filaments (PHFs) that comprise the…”
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Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates by Löffler, Tina, Flunkert, Stefanie, Taub, Nicole, Schofield, Emma L., Ward, Malcolm A., Windisch, Manfred, Hutter-Paier, Birgit

“…The role of hyperphosphorylation of the microtubule-associated protein tau in the pathological processes of several neurodegenerative diseases is becoming…”
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Phospho-tau SRM: A multisite phosphorylation assay for tau protein by Ward, Malcolm A, Weston, Andrew, Byers, Helen, Schofield, Emma

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Evaluation of CSF cystatin C, beta-2-microglobulin, and VGF as diagnostic biomarkers of Alzheimer's disease using SRM by Ward, Malcolm A, Soininen, Hilkka, O'Brien, Darragh, Lovestone, Simon, Hallikainen, Merja, Herukka, Sanna-Kaisa, Schofield, Emma, Campbell, James, Dayon, Loic

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Reversible cysteine-targeted oxidation of proteins during renal oxidative stress by Eaton, Philip, Jones, Miriam E, McGregor, Emma, Dunn, Michael J, Leeds, Nicola, Byers, Helen L, Leung, Kit-Yi, Ward, Malcolm A, Pratt, Julian R, Shattock, Michael J

“…Biotin-cysteine was used to study protein S-thiolation in isolated rat kidneys subjected to ischemia and reperfusion. After 40 min of ischemia, total protein…”
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Urine protein concentration estimation for biomarker discovery by Mistry, Hiten D, Bramham, Kate, Weston, Andrew J, Ward, Malcolm A, Thompson, Andrew J, Chappell, Lucy C

“…Abstract Recent advances have been made in the study of urinary proteomics as a diagnostic tool for renal disease and pre-eclampsia which requires accurate…”
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