Search Results - "Ward, Lesley A."

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation by Pikor, Natalia B., Astarita, Jillian L., Summers-Deluca, Leslie, Galicia, Georgina, Qu, Joy, Ward, Lesley A., Armstrong, Susan, Dominguez, Claudia X., Malhotra, Deepali, Heiden, Brendan, Kay, Robert, Castanov, Valera, Touil, Hanane, Boon, Louis, O’Connor, Paul, Bar-Or, Amit, Prat, Alexandre, Ramaglia, Valeria, Ludwin, Samuel, Turley, Shannon J., Gommerman, Jennifer L.

“…Tertiary lymphoid tissues (TLTs) have been observed in the meninges of multiple sclerosis (MS) patients, but the stromal cells and molecular signals that…”
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BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas by Bari, Muhammad F, Brown, Helen, Nicholson, Andrew G, Kerr, Keith M, Gosney, John R, Wallace, William A, Soomro, Irshad, Muller, Salli, Peat, Danielle, Moore, Jonathan D, Ward, Lesley A, Freidin, Maxim B, Lim, Eric, Vatish, Manu, Snead, David R J

“…Aims Discriminating small‐cell lung carcinoma (SCLC) from large‐cell neuroendocrine carcinoma (LCNEC) rests on morphological criteria, and reproducibility has…”
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Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV by Matveev, Vitaliy A., Mihelic, Erik Z., Benko, Erika, Budylowski, Patrick, Grocott, Sebastian, Lee, Terry, Korosec, Chapin S., Colwill, Karen, Stephenson, Henry, Law, Ryan, Ward, Lesley A., Sheikh-Mohamed, Salma, Mailhot, Geneviève, Delgado-Brand, Melanie, Pasculescu, Adrian, Wang, Jenny H., Qi, Freda, Tursun, Tulunay, Kardava, Lela, Chau, Serena, Samaan, Philip, Imran, Annam, Copertino, Dennis C., Chao, Gary, Choi, Yoojin, Reinhard, Robert J., Kaul, Rupert, Heffernan, Jane M., Jones, R. Brad, Chun, Tae-Wook, Moir, Susan, Singer, Joel, Gommerman, Jennifer, Gingras, Anne-Claude, Kovacs, Colin, Ostrowski, Mario

“…Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity of these vaccines and…”
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Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses by Currie, Elissa G, Coburn, Bryan, Porfilio, Elisa A, Lam, Ping, Rojas, Olga L, Novak, Jan, Yang, Stuart, Chowdhury, Raad B, Ward, Lesley A, Wang, Pauline W, Khaleghi, Khashayar, An, James, Crome, Sarah Q, Hladunewich, Michelle A, Barbour, Sean J, Cattran, Daniel C, Parekh, Rulan S, Licht, Christoph, John, Rohan, Kaul, Rupert, Croitoru, Kenneth, Gray-Owen, Scott D, Guttman, David S, Gommerman, Jennifer L, Reich, Heather N

“…IgA nephropathy (IgAN) is a leading cause of kidney failure, yet little is known about the immunopathogenesis of this disease. IgAN is characterized by…”
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Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation by Zuo, Michelle, Fettig, Naomi M, Bernier, Louis-Philippe, Pössnecker, Elisabeth, Spring, Shoshana, Pu, Annie, Ma, Xianjie I, Lee, Dennis Sw, Ward, Lesley A, Sharma, Anshu, Kuhle, Jens, Sled, John G, Pröbstel, Anne-Katrin, MacVicar, Brian A, Osborne, Lisa C, Gommerman, Jennifer L, Ramaglia, Valeria

“…People living with multiple sclerosis (MS) experience episodic CNS white matter lesions instigated by autoreactive T cells. With age, patients with MS show…”
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Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets by Tusche, Michael W, Ward, Lesley A, Vu, Frances, McCarthy, Doug, Quintela-Fandino, Miguel, Ruland, Jurgen, Gommerman, Jennifer L, Mak, Tak W

“…B cell activation factor of the TNF family (BAFF) activates noncanonical nuclear factor kappaB (NF-kappaB) heterodimers that promote B cell survival. We show…”
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The viability of electrical energy storage for low-energy households by Grantham, Adrian, Pudney, Peter, Ward, Lesley A., Whaley, David, Boland, John

“…•We simulate the operation of battery storage using data from low-energy households.•We calculate the impact on the annual amount and cost of imported…”
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Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 by Rojas, Olga L., Pröbstel, Anne-Katrin, Porfilio, Elisa A., Wang, Angela A., Charabati, Marc, Sun, Tian, Lee, Dennis S.W., Galicia, Georgina, Ramaglia, Valeria, Ward, Lesley A., Leung, Leslie Y.T., Najafi, Ghazal, Khaleghi, Khashayar, Garcillán, Beatriz, Li, Angela, Besla, Rickvinder, Naouar, Ikbel, Cao, Eric Y., Chiaranunt, Pailin, Burrows, Kyle, Robinson, Hannah G., Allanach, Jessica R., Yam, Jennifer, Luck, Helen, Campbell, Daniel J., Allman, David, Brooks, David G., Tomura, Michio, Baumann, Ryan, Zamvil, Scott S., Bar-Or, Amit, Horwitz, Marc S., Winer, Daniel A., Mortha, Arthur, Mackay, Fabienne, Prat, Alexandre, Osborne, Lisa C., Robbins, Clinton, Baranzini, Sergio E., Gommerman, Jennifer L.

“…Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source and role in MS remains unclear. We find that some PC in the CNS of…”
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Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months after Symptom Onset by Law, Jaclyn C, Girard, Melanie, Chao, Gary Y C, Ward, Lesley A, Isho, Baweleta, Rathod, Bhavisha, Colwill, Karen, Li, Zhijie, Rini, James M, Yue, Feng Yun, Mubareka, Samira, McGeer, Allison J, Ostrowski, Mario A, Gommerman, Jennifer L, Gingras, Anne-Claude, Watts, Tania H

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces T cell, B cell, and Ab responses that are detected for several months in recovered…”
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Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 by Rojas, Olga L., Pröbstel, Anne-Katrin, Porfilio, Elisa A., Wang, Angela A., Charabati, Marc, Sun, Tian, Lee, Dennis S.W., Galicia, Georgina, Ramaglia, Valeria, Ward, Lesley A., Leung, Leslie Y.T., Najafi, Ghazal, Khaleghi, Khashayar, Garcillán, Beatriz, Li, Angela, Besla, Rickvinder, Naouar, Ikbel, Cao, Eric Y., Chiaranunt, Pailin, Burrows, Kyle, Robinson, Hannah G., Allanach, Jessica R., Yam, Jennifer, Luck, Helen, Campbell, Daniel J., Allman, David, Brooks, David G., Tomura, Michio, Baumann, Ryan, Zamvil, Scott S., Bar-Or, Amit, Horwitz, Marc S., Winer, Daniel A., Mortha, Arthur, Mackay, Fabienne, Prat, Alexandre, Osborne, Lisa C., Robbins, Clinton, Baranzini, Sergio E., Gommerman, Jennifer L.

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Characterization of compactness of commutators of bilinear singular integral operators by CHAFFEE, LUCAS, CHEN, PENG, HAN, YANCHANG, TORRES, RODOLFO H., WARD, LESLEY A.

“…The commutators of bilinear Calderón-Zygmund operators and pointwise multiplication with a symbol in \textup {CMO} are bilinear compact operators on products…”
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CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein–Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response by Lee, Dennis S. W., Yam, Jennifer Y., Grasmuck, Camille, Dasoveanu, Dragos, Michel, Laure, Ward, Lesley A., Rojas, Olga L., Zandee, Stephanie, Bourbonnière, Lyne, Ramaglia, Valeria, Bar-Or, Amit, Prat, Alexandre, Gommerman, Jennifer L.

“…B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms that guide B cell activation in the periphery and subsequent…”
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Functions of Bounded Mean Oscillation and Quasisymmetric Mappings on Spaces of Homogeneous Type by Nguyen, Trang T. T., Ward, Lesley A.

“…We establish a connection between the function space  BMO and the theory of quasisymmetric mappings on spaces of homogeneous type  X ~ : = ( X , ρ , μ ) . The…”
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Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node by Li, Conglei, Ward, Lesley A., Nguyen, Albert, Lam, Evelyn, Dasoveanu, Dragos, Ahmed, Musaddeque, Haniuda, Kei, Buechler, Matthew B., He, Housheng Hansen, Ludewig, Burkhard, McNagny, Kelly Marshall, Gommerman, Jennifer L.

“…Although eosinophils are important contributors to mucosal immune responses, mechanisms that regulate their accumulation in mucosal-associated lymphoid tissues…”
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AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely by Boulianne, Bryant, Le, Michael X, Ward, Lesley A, Meng, Lingjin, Haddad, Dania, Li, Conglei, Martin, Alberto, Gommerman, Jennifer L

“…Upon activation with T-dependent Ag, B cells enter germinal centers (GC) and upregulate activation-induced deaminase (AID). AID(+) GC B cells then undergo…”
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Marcinkiewicz-Type Spectral Multipliers on Hardy and Lebesgue Spaces on Product Spaces of Homogeneous Type by Chen, Peng, Duong, Xuan Thinh, Li, Ji, Ward, Lesley A., Yan, Lixin

“…Let X 1 and X 2 be metric spaces equipped with doubling measures and let L 1 and L 2 be nonnegative self-adjoint operators acting on L 2 ( X 1 ) and L 2 ( X 2…”
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Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in Aicda -/- and Ung -/- Mice by Galicia, Georgina, Lee, Dennis S W, Ramaglia, Valeria, Ward, Lesley A, Yam, Jennifer Y, Leung, Leslie Y T, Li, Rui, Handy, Marcus, Zhang, Junxian, Drohomyrecky, Paulina C, Lancaster, Eric, Bar-Or, Amit, Martin, Alberto, Gommerman, Jennifer L

“…B cell-depleting therapies have been shown to ameliorate symptoms in multiple sclerosis (MS) patients; however, the mechanism of action remains unclear…”
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Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation by Zuo, Michelle, Fettig, Naomi M, Bernier, Louis-Philippe, Pössnecker, Elisabeth, Spring, Shoshana, Pu, Annie, Ma, Xianjie I, Lee, Dennis Sw, Ward, Lesley A, Sharma, Anshu, Kuhle, Jens, Sled, John G, Pröbstel, Anne-Katrin, MacVicar, Brian A, Osborne, Lisa C, Gommerman, Jennifer L, Ramaglia, Valeria

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A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology by Ng, Dennis, Maître, Blandine, Cummings, Derek, Lin, Albert, Ward, Lesley A, Rahbar, Ramtin, Mossman, Karen L, Ohashi, Pamela S, Gommerman, Jennifer L

“…Type I IFNs (IFN-I) are cytokines that can mediate both immune suppression and activation. Dendritic cells (DC) are significant producers of IFN-I, and…”
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Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury by Ward, Lesley A, Lee, Dennis Sw, Sharma, Anshu, Wang, Angela, Naouar, Ikbel, Ma, Xianjie I, Pikor, Natalia, Nuesslein-Hildesheim, Barbara, Ramaglia, Valeria, Gommerman, Jennifer L

“…Subpial demyelination is a specific hallmark of multiple sclerosis and a correlate of disease progression. Although the mechanism(s) that mediate pathogenesis…”
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