Search Results - "Ward, Karen M"

Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models by Beaumont, Vahri, Zhong, Sheng, Lin, Hai, Xu, WenJin, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Wadel, Kristian, Buisson, Bruno, Padovan-Neto, Fernando E., Chakroborty, Shreaya, Ward, Karen M., Harms, John F., Beltran, Jose, Kwan, Mei, Ghavami, Afshin, Häggkvist, Jenny, Tóth, Miklós, Halldin, Christer, Varrone, Andrea, Schaab, Christoph, Dybowski, J. Nikolaj, Elschenbroich, Sarah, Lehtimäki, Kimmo, Heikkinen, Taneli, Park, Larry, Rosinski, James, Mrzljak, Ladislav, Lavery, Daniel, West, Anthony R., Schmidt, Christopher J., Zaleska, Margaret M., Munoz-Sanjuan, Ignacio

“…Huntington’s disease (HD) symptoms are driven to a large extent by dysfunction of the basal ganglia circuitry. HD patients exhibit reduced striatal…”
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D 2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine by Shen, Yudao, McCorvy, John D, Martini, Michael L, Rodriguiz, Ramona M, Pogorelov, Vladimir M, Ward, Karen M, Wetsel, William C, Liu, Jing, Roth, Bryan L, Jin, Jian

“…Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially…”
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D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine by Shen, Yudao, McCorvy, John D, Martini, Michael L, Rodriguiz, Ramona M, Pogorelov, Vladimir M, Ward, Karen M, Wetsel, William C, Liu, Jing, Roth, Bryan L, Jin, Jian

“…Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially…”
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A Friendships and Dating Program for Adults with Intellectual and Developmental Disabilities: A Formative Evaluation by Ward, Karen M, Atkinson, Julie P, Smith, Curtis A, Windsor, Richard

“…Meaningful relationships with others are often elusive for people with intellectual and developmental disabilities, but no less desired for their full…”
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A process evaluation of the Friendships and Dating Program for adults with developmental disabilities: Measuring the fidelity of program delivery by Ward, Karen M., Windsor, Richard, Atkinson, Julie P.

“…► A study of an abuse-prevention program for adults with developmental disabilities. ► A Process Evaluation Model documented the level of treatment fidelity. ►…”
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Romantic Relationships and Interpersonal Violence among Adults with Developmental Disabilities by Ward, Karen M, Bosek, Rebecca L, Trimble, Erin L

“…Romantic relationships are important in the lives of adults with developmental disabilities. The purpose of this study was to explore dating and romantic…”
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Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets : Role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia by JOHNSON, David E, YAMAZAKI, Hanae, WARD, Karen M, SCHMIDT, Anne W, LEBEL, Wesley S, TREADWAY, Judith L, GIBBS, E. Michael, ZAWALICH, Walter S, ROLLEMA, Hans

“…Treatment with the atypical antipsychotics olanzapine and clozapine has been associated with an increased risk for deterioration of glucose homeostasis,…”
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Poster #S45 DEVELOPMENT OF NOVEL PET LIGANDS (PF-04831704 AND PF-06327104) FOR PDE10A by Ward, Karen M, Chen, Laigao, Zhang, Lei, Smith, Deborah, Chappie, Tom, Schmidt, Christopher, Grimwood, Sarah, O'Connor, Rebecca, Rizzo, Stacey, Schildknegt, Klaas

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The Development of an Assessment of Interpersonal Violence for Individuals with Intellectual and Developmental Disabilities by Atkinson, Julie P., Ward, Karen M.

“…Individuals with intellectual and developmental disabilities experience rates of interpersonal violence much higher than those in the general population. Not…”
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Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents by Dow, Robert L, Carpino, Philip A, Gautreau, Denise, Hadcock, John R, Iredale, Philip A, Kelly-Sullivan, Dawn, Lizano, Jeffrey S, O’Connor, Rebecca E, Schneider, Steven R, Scott, Dennis O, Ward, Karen M

“…Antagonism of cannabinoid-1 (CB1) receptor signaling has been demonstrated to inhibit feeding behaviors in humans, but CB1-mediated central nervous system…”
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An octahydro-cyclopenta[ c]pyrrole series of inhibitors of the type 1 glycine transporter by Lowe, John A., DeNinno, Shari L., Drozda, Susan E., Schmidt, Christopher J., Ward, Karen M., David Tingley, F., Sanner, Mark, Tunucci, Don, Valentine, James

“…The discovery of a potent, selective inhibitor of the type 1 glycine transporter, 9d, is reported. We describe a novel series of inhibitors of the type 1…”
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Effectiveness of a model for training direct service personnel in rural and remote locations by A Wilcox, Peter W Dowrick, Karen M Ward, David

“…Alaska's vast land mass and diversified urban, rural, and remote communities require innovative strategies to meet training needs for direct service personnel…”
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A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists by Lowe, John A., DeNinno, Shari L., Coe, Jotham W., Zhang, Lei, Mente, Scot, Hurst, Raymond S., Mather, Robert J., Ward, Karen M., Shrikhande, Alka, Rollema, Hans, Johnson, David E., Horner, Weldon, Gorczyca, Roxanne, Tingley, F. David, Kozak, Rouba, Majchrzak, Mark J., Tritto, Theresa, Sadlier, Jen, Shaffer, Chris L., Ellerbrock, Brenda, Osgood, Sarah M., MacDougall, Mary C., McDowell, Laura L.

“…We report the discovery of compound 17a, a potent α3β4 and α6/4β4 receptor agonist. We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as…”
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The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release by Johnson, David E., Nedza, Frank M., Spracklin, Douglas K., Ward, Karen M., Schmidt, Anne W., Iredale, Philip A., Godek, Dennis M., Rollema, Hans

“…Olanzapine and clozapine produce robust increases in hippocampal acetylcholine release during acetylcholinesterase inhibition, while other antipsychotics,…”
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Video feedforward in the support of a man with intellectual disability and inappropriate sexual behaviour by Dowrick, Peter W., Ward, Karen M.

“…Inappropriate sexual behaviour, paedophilia in particular, is a socially significant issue. When this matter is complicated by issues related to intellectual…”
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New bicyclic cannabinoid receptor-1 (CB 1-R) antagonists by Carpino, Philip A., Griffith, David A., Sakya, Subas, Dow, Robert L., Black, Shawn C., Hadcock, John R., Iredale, Philip A., Scott, Dennis O., Fichtner, Michael W., Rose, Colin R., Day, Robert, Dibrino, Joseph, Butler, Mary, DeBartolo, Demetria B., Dutcher, Darrin, Gautreau, Denise, Lizano, Jeff S., O’Connor, Rebecca E., Sands, Michelle A., Kelly-Sullivan, Dawn, Ward, Karen M.

“…A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB 1-R antagonists and inverse agonists…”
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Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase by Nason, Deane M, Heck, Steven D, Bodenstein, Mathew S, Lowe, John A, Nelson, Robert B, Liston, Dane R, Nolan, Charles E, Lanyon, Lorraine F, Ward, Karen M, Volkmann, Robert A

“…The synthesis and nNOS/eNOS activity of 6-(4-(dimethylaminoalkyl)/-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and…”
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Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist by Hadcock, John R, Carpino, Philip A, Iredale, Philip A, Dow, Robert L, Gautreau, Denise, Thiede, Lucinda, Kelly-Sullivan, Dawn, Lizano, Jeffrey S, Liu, Xingrong, Van Deusen, Jeffrey, Ward, Karen M, O'Connor, Rebecca E, Black, Shawn C, Griffith, David A, Scott, Dennis O

“…Cannabinoid 1 (CB1) receptor antagonists exhibit pharmacological properties favorable for the treatment of obesity and other related metabolic disorders…”
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Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets by Johnson, David E., Yamazaki, Hanae, Ward, Karen M., Schmidt, Anne W., Lebel, Wesley S., Treadway, Judith L., Gibbs, E. Michael, Zawalich, Walter S., Rollema, Hans

“…Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets Role of Muscarinic Antagonism in Antipsychotic-Induced…”
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Community Services, Issues, and Service Gaps for Individuals with Developmental Disabilities Who Exhibit Inappropriate Sexual Behaviors by Ward, Karen M, Pfeiffer, Karl T, Trigler, Jordan S

“…A national survey of 243 community agencies evaluated services provided for individuals with developmental disabilities who exhibit high-risk sexual behaviors…”
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