Human papillomavirus genotype distribution in cervical samples among vaccine naïve Barbados women

Human papillomavirus genotype distribution in cervical samples among vaccine naïve Barbados women

Purpose This study was undertaken to provide baseline HPV genotype distribution among women in Barbados before HPV immunization was introduced. This information would then be used as a denominator for post-vaccine surveillance and is expected to aid in understanding the effect of vaccination on cerv...

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Bibliographic Details
Published in:Cancer causes & control Vol. 28; no. 11; pp. 1323 - 1332
Main Authors: Ward, Juann M., Schmalenberg, Kolin, Antonishyn, Nick A., Hambleton, Ian R., Blackman, Elizabeth L., Levett, Paul N., Gittens-St.Hilaire, Marquita V.
Format: Journal Article
Language:English
Published: Cham Springer Science + Business Media 01-11-2017
Springer International Publishing
Springer Nature B.V
Subjects:
Adolescent
Adult
Aged
Barbados
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cellular biology
Cervix Uteri - virology
Cytology
Demographics
Epidemiology
Female
Genotype
Genotyping
Health risk assessment
Hematology
Human papillomavirus
Humans
Immunization
Infections
Middle Aged
Oncology
ORIGINAL PAPER
Papillomaviridae - genetics
Papillomavirus Infections - prevention & control
Papillomavirus Infections - virology
Papillomavirus Vaccines
Population studies
Public Health
Risk
Sexual behavior
Vaccination
Vaccines
Young Adult
Barbados
HPV 45
Human papillomavirus
Barbados
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Summary:Purpose This study was undertaken to provide baseline HPV genotype distribution among women in Barbados before HPV immunization was introduced. This information would then be used as a denominator for post-vaccine surveillance and is expected to aid in understanding the effect of vaccination on cervical disease in Barbados. Methods Liquid-based cytology specimens were collected from 413 women (age range 18–65 years) attending three clinics, in a pre-vaccination, population-based study. After consent was obtained, sexual behavior and socio-demographic information were acquired from self-administered questionnaires. HPV types were detected using Luminex-based HPV PCR genotyping methodology. Results HPV was detected in 33% (135/413) of the subjects overall (95% CI 32.7, 33.37), of which 70% (95/135) were high-risk types, with 35 different types being detected in this population. Single and multiple high-risk HPV types were detected in 14% (13/95) and 31% (29/95) of the subjects, respectively. The most common high-risk HPV types detected were 45( n  = 22, 23%), 16 ( n  = 17, 18%), 52 ( n  = 16, 17%), and 58 ( n  = 10, 11%). Persons with the highest level of infection by age were 21–25 ( n  = 25/135;19%; 95% CI 18.8, 19.3); 26–30 ( n  = 22/135;16%; 95% CI 15.9, 16.2); 31–35 ( n  = 19/135;14%; 95% CI 13.9, 14.2); 36–40 ( n  = 17/135;13%; 95% CI 12.2, 13.2), and 18–21 ( n  = 15/135;11%; 95% CI 10.9, 11.2). 91/413 (22%) persons had a normal cytology result. Conclusion A high prevalence of HPV type 45 was found in the screening population of women in Barbados. The results of cytological examinations and HPV positivity suggest that both tests should be used for greater reliable diagnosis of HPV infection.
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ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-017-0959-y