Search Results - "Ward, Jon"

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1 by Hinks, Timothy S.C., MD, Brown, Tom, MD, Lau, Laurie C.K., PhD, Rupani, Hitasha, MD, Barber, Clair, BSc, Elliott, Scott, BSc, Ward, Jon A., BSc, Ono, Junya, BSc, Ohta, Shoichiro, MD, Izuhara, Kenji, MD, Djukanović, Ratko, MD, Kurukulaaratchy, Ramesh J., MD, Chauhan, Anoop, MD, Howarth, Peter H., MD

“…Background Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood. Objective We aimed to…”
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Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms by Hinks, Timothy S.C., MD, Zhou, Xiaoying, PhD, Staples, Karl J., PhD, Dimitrov, Borislav D., MD, Manta, Alexander, PhD, Petrossian, Tanya, PhD, Lum, Pek Y., PhD, Smith, Caroline G., RN, Ward, Jon A., BSc, Howarth, Peter H., MD, Walls, Andrew F., PhD, Gadola, Stephan D., MD, Djukanović, Ratko, MD

“…Background Asthma is a chronic inflammatory disease involving diverse cells and mediators whose interconnectivity and relationships to asthma severity are…”
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Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines by Moragas, Toni, Liffey, Ryan M., Regentová, Dominika, Ward, Jon-Paul S., Dutton, Justine, Lewis, William, Churcher, Ian, Walton, Lesley, Souto, José A., Stockman, Robert A.

“…A novel rearrangement of 2‐vinyl aziridine 2‐carboxylates to unusual chiral cyclic sulfoximines is described herein. The method allows the synthesis of…”
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Cross-layer traffic analysis countermeasures against adaptive attackers of wireless sensor networks by Ward, Jon R., Younis, Mohamed

“…In most Wireless Sensor Network (WSN) applications the sensor nodes forward their measurements to a central base station (BS). The unique role of the BS makes…”
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Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17 by Staples, Karl J., PhD, Hinks, Timothy S.C., MB BS, Ward, Jon A., BSc (Hons), Gunn, Victoria, BM, Smith, Caroline, BA (Hons), Djukanović, Ratko, MD

“…Background Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic…”
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Targeting Neutrophilic Inflammation Using Polymersome-Mediated Cellular Delivery by Robertson, James D, Ward, Jon R, Avila-Olias, Milagros, Battaglia, Giuseppe, Renshaw, Stephen A

“…Neutrophils are key effector cells in inflammation and play an important role in neutralizing invading pathogens. During inflammation resolution, neutrophils…”
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Regulation of neutrophil senescence by microRNAs by Ward, Jon R, Heath, Paul R, Catto, James W, Whyte, Moira K B, Milo, Marta, Renshaw, Stephen A

“…Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a…”
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The low-toxicity versions of LPS, MPL® adjuvant and RC529, are efficient adjuvants for CD4+ T cells by Thompson, Bruce S., Chilton, Paula M., Ward, Jon R., Evans, Jay T., Mitchell, Thomas C.

“…Lipopolysaccharide (LPS) has long been known to enhance innate and adaptive immune responses; however, its extreme toxicity precludes its use in clinical…”
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The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma by Rynne, Jennifer, Ortiz-Zapater, Elena, Bagley, Dustin C, Zanin, Onofrio, Doherty, George, Kanabar, Varsha, Ward, Jon, Jackson, David J, Parsons, Maddy, Rosenblatt, Jody, Adcock, Ian M, Martinez-Nunez, Rocio T

“…Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have…”
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Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms by Ward, Jon R., West, Peter W., Ariaans, Mark P., Parker, Lisa C., Francis, Sheila E., Crossman, David C., Sabroe, Ian, Wilson, Heather L.

“…The processing and regulated secretion of IL-1β are critical points of control of the biological activity of this important pro-inflammatory cytokine. IL-1β is…”
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Communications Skills in the Pharmacy Profession: A Cross Sectional Survey of UK Registered Pharmacists and Pharmacy Educators by Jalal, Zahraa, Cox, Anthony, Goel, Neera, Vaitha, Nikita, King, Kathryn, Ward, Jon

“…To determine UK pharmacists' experiences of their current communication skills and undergraduate training and to identify communication skills training and…”
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Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor by Ward, Jon R, Bingle, Lynne, Judge, Heather M, Brown, Simon B, Storey, Robert F, Whyte, Moira K B, Dower, Steven K, Buttle, David J, Sabroe, Ian

“…Inappropriate platelet activation is a feature of acute and chronic diseases such as disseminated intravascular coagulation (DIC) and atherosclerosis. Since…”
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A cross-layer defense scheme for countering traffic analysis attacks in Wireless Sensor Networks by Ward, Jon R., Younis, Mohamed

“…In most Wireless Sensor Network (WSN) applications the sensors forward their readings to a central sink or base station (BS). The unique role of the BS makes…”
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Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data by Hinks, Timothy, Dr, Zhou, Xiaoying, PhD, Staples, Karl, PhD, Dimitrov, Borislav, MD, Manta, Alexander, PhD, Petrossian, Tanya, PhD, Lum, Pek, PhD, Smith, Caroline, RN, Ward, Jon, BSc, Howarth, Peter, MD, Walls, Andrew, PhD, Gadola, Stephan D, MD, Djukanović, Ratko, MD

“…Abstract Background Incomplete understanding of mechanisms and clinicopathobiological heterogeneity in asthma hinders research progress. Pathogenic roles for…”
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Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses by Morris, Gavin E, Parker, Lisa C, Ward, Jon R, Jones, Elizabeth C, Whyte, Moira K.B, Brightling, Christopher E, Bradding, Peter, Dower, Steven K, Sabroe, Ian

“…Viral and bacterial pathogens cause inflammation via Toll-like receptor (TLR) signaling. We have shown that effective responses to LPS may depend on…”
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Anchialine biodiversity in the Turks and Caicos Islands: New discoveries and current faunal composition by Gonzalez, Brett, Martínez, Alejandro, Olesen, Jørgen, Truskey, Sarit, Ballou, Lauren, Allentoft-Larsen, Marc, Daniels, Joost, Heinerth, Paul, Parrish, Mark, Manco, Naqqi, Ward, Jon, Iliffe, Thomas, Osborn, Karen, Worsaae, Katrine

“…Lying at the southernmost point of the Lucayan Archipelago, the Turks and Caicos Islands are amongst the better studied localities for anchialine cave…”
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Distributed Beamforming Relay Selection to Increase Base Station Anonymity in Wireless Ad Hoc Networks by Ward, Jon R., Younis, Mohamed

“…Wireless ad hoc networks have become valuable assets to both the commercial and military communities with applications ranging from industrial control on a…”
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Characterization of TRIF selectivity in the AGP class of lipid A mimetics: Role of secondary lipid chains by Khalaf, Juhienah K., Bowen, William S., Bazin, Hélène G., Ryter, Kendal T., Livesay, Mark T., Ward, Jon R., Evans, Jay T., Johnson, David A.

“…[Display omitted] TLR4 agonists that favor TRIF-dependent signaling and the induction of type 1 interferons may have potential as vaccine adjuvants with…”
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Lost in Translation: Lack of CD4 Expression due to a Novel Genetic Defect by Lisco, Andrea, Ye, Peiying, Wong, Chun-Shu, Pei, Luxin, Hsu, Amy P, Mace, Emily M, Orange, Jordan S, Lage, Silvia Lucena, Ward, Addison Jon, Migueles, Stephen A, Connors, Mark, Anderson, Megan V, Buckner, Clarisa M, Moir, Susan, Rupert, Adam, Dulau-Florea, Alina, Ogbogu, Princess, Timberlake, Dylan, Notarangelo, Luigi D, Pittaluga, Stefania, Abraham, Roshini S, Sereti, Irini

“…Abstract CD4 expression identifies a subset of mature T cells primarily assisting the germinal center reaction and contributing to CD8+ T-cell and B-cell…”
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Asthmatic Bronchial Epithelium Is More Susceptible to Oxidant-Induced Apoptosis by Bucchieri, Fabio, Puddicombe, Sarah M, Lordan, James L, Richter, Audrey, Buchanan, Diane, Wilson, Susan J, Ward, Jon, Zummo, Giovanni, Howarth, Peter H, Djukanovic, Ratko, Holgate, Stephen T, Davies, Donna E

“…Abnormal apoptotic mechanisms are associated with disease pathogenesis. Because the asthmatic bronchial epithelium is characteristically damaged with loss of…”
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