Search Results - "Ward, Jeremy P."

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma by Yarova, Polina L, Stewart, Alecia L, Sathish, Venkatachalem, Britt, Jr, Rodney D, Thompson, Michael A, P Lowe, Alexander P, Freeman, Michelle, Aravamudan, Bharathi, Kita, Hirohito, Brennan, Sarah C, Schepelmann, Martin, Davies, Thomas, Yung, Sun, Cholisoh, Zakky, Kidd, Emma J, Ford, William R, Broadley, Kenneth J, Rietdorf, Katja, Chang, Wenhan, Bin Khayat, Mohd E, Ward, Donald T, Corrigan, Christopher J, T Ward, Jeremy P, Kemp, Paul J, Pabelick, Christina M, Prakash, Y S, Riccardi, Daniela

“…Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma that are accompanied by increases in certain polycations, such as…”
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Hypoxic pulmonary vasoconstriction by Sylvester, J T, Shimoda, Larissa A, Aaronson, Philip I, Ward, Jeremy P T

“…It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to…”
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Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury by Tsantoulas, Christoforos, Zhu, Lan, Shaifta, Yasin, Grist, John, Ward, Jeremy P T, Raouf, Ramin, Michael, Gregory J, McMahon, Stephen B

“…Chronic neuropathic pain affects millions of individuals worldwide, is typically long-lasting, and remains poorly treated with existing therapies. Neuropathic…”
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Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem by Ward, Jeremy PT, McMurtry, Ivan F

“…Hypoxic pulmonary vasoconstriction (HPV) normally optimises ventilation–perfusion matching in the lung, but leads to pulmonary hypertension (PH) under…”
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Hypoxic pulmonary vasoconstriction: mechanisms and controversies by Aaronson, Philip I., Robertson, Tom P., Knock, Gregory A., Becker, Silke, Lewis, Tristan H., Snetkov, Vladimir, Ward, Jeremy P. T.

“…The pulmonary circulation differs from the systemic in several important aspects, the most important being that pulmonary arteries constrict to moderate…”
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Dietary soy isoflavone‐induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo by Mahn, Katharina, Borrás, Consuelo, Knock, Greg A., Taylor, Paul, Khan, Imran Y., Sugden, David, Poston, Lucilla, Ward, Jeremy P., Sharpe, Richard M., Viña, Jose, Aaronson, Philip I., Mann, Giovanni E.

“…ABSTRACTEpidemiological evidence suggests that populations consuming large amounts of soy protein have a reduced incidence of coronary heart disease (1–5). The…”
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Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release by Connolly, Michelle J., Prieto‐Lloret, Jesus, Becker, Silke, Ward, Jeremy P. T., Aaronson, Philip I.

“…Key points •  Hypoxic pulmonary vasoconstriction (HPV) is a mechanism by which pulmonary arteries maintain blood oxygenation during alveolar hypoxia. •  HPV is…”
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Divergent modulation of Rho‐kinase and Ca2+ influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle by Shaifta, Yasin, Irechukwu, Nneka, Prieto‐Lloret, Jesus, MacKay, Charles E, Marchon, Keisha A, Ward, Jeremy P T, Knock, Greg A

“…Background and Purpose The importance of tyrosine kinases in airway smooth muscle (ASM) contraction is not fully understood. The aim of this study was to…”
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Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery by Knock, Greg A., Snetkov, Vladimir A., Shaifta, Yasin, Drndarski, Svetlana, Ward, Jeremy P.T., Aaronson, Philip I.

“…Aims We investigated the role of src-family kinases (srcFKs) in hypoxic pulmonary vasoconstriction (HPV) and how this relates to Rho-kinase-mediated Ca2+…”
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Diminished sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma by Mahn, Katharina, Hirst, Stuart J, Ying, Sun, Holt, Mark R, Lavender, Paul, Ojo, Oluwaseun O, Siew, Leonard, Simcock, David E, McVicker, Clare G, Kanabar, Varsha, Snetkov, Vladimir A, O'Connor, Brian J, Karner, Charlotta, Cousins, David J, Macedo, Patricia, Chung, K. Fan, Corrigan, Christopher J, Ward, Jeremy P.T, Lee, Tak H

“…Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and…”
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Superoxide differentially controls pulmonary and systemic vascular tone through multiple signalling pathways by SNETKOV, Vladimir A, SMIRNOV, Sergey V, KUA, Justin, AARONSON, Philip I, WARD, Jeremy P. T, KNOCK, Greg A

“…the aim of this study was to determine the relative importance of Ca(2+) sensitization, ion channels, and intracellular Ca(2+) ([Ca(2+)](i)) in the mixed…”
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Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery by Knock, Greg A., Shaifta, Yasin, Snetkov, Vladimir A., Vowles, Benjamin, Drndarski, Svetlana, Ward, Jeremy P.T., Aaronson, Philip I.

“…Aims We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction…”
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Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor by Leach, Richard M., Hill, Heidi M., Snetkov, Vladimir A., Robertson, Thomas P., Ward, Jeremy P. T.

“…The mechanisms responsible for sensing hypoxia and initiating hypoxic pulmonary vasoconstriction (HPV) are unclear. We therefore examined the roles of the…”
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Communication and information technology in medical education by Ward, Jeremy PT, Gordon, Jill, Field, Michael J, Lehmann, Harold P

“…The past few years have seen rapid advances in communication and information technology (C&IT), and the pervasion of the worldwide web into everyday life has…”
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β1-Integrins mediate enhancement of airway smooth muscle proliferation by collagen and fibronectin by NGUYEN, Trang T.-B, WARD, Jeremy P. T, HIRST, Stuart J

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Oxygen sensors in context by Ward, Jeremy P.T.

“…The ability to adapt to changes in the availability of O 2 provides a critical advantage to all O 2-dependent lifeforms. In mammals it allows optimal matching…”
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Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era? by Riccardi, Daniela, Ward, Jeremy Pt, Yarova, Polina L, Janssen, Luke J, Lee, Tak Hong, Ying, Sun, Corrigan, Chris J

“…In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger…”
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Low Concentrations of Sphingosylphosphorylcholine Enhance Pulmonary Artery Vasoreactivity: The Role of Protein Kinase Cδ and Ca2+ Entry by Snetkov, Vladimir A, Thomas, Gavin D, Teague, Bonnie, Leach, Richard M, Shaifta, Yasin, Knock, Greg A, Aaronson, Philip I, Ward, Jeremy P.T

“…Sphingosylphosphorylcholine (SPC) is a powerful vasoconstrictor, but in vitro its EC50 is ≈100-fold more than plasma concentrations. We examined whether…”
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Redox regulation of protein kinases as a modulator of vascular function by Knock, Greg A, Ward, Jeremy P T

“…Reactive oxygen species (ROS) are continuously generated in vascular tissues by various oxidoreductase enzymes. They contribute to normal cell signaling, and…”
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ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1 by MacKay, Charles E., Shaifta, Yasin, Snetkov, Vladimir V., Francois, Asvi A., Ward, Jeremy P.T., Knock, Greg A.

“…The role of reactive oxygen species (ROS) in smooth muscle contraction is poorly understood. We hypothesised that G-protein coupled receptor (GPCR) activation…”
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