Search Results - "Ward, Fred R."

Structure of the bacterial ribosome at 2 Å resolution by Watson, Zoe L, Ward, Fred R, Méheust, Raphaël, Ad, Omer, Schepartz, Alanna, Banfield, Jillian F, Cate, Jamie Hd

“…Using cryo-electron microscopy (cryo-EM), we determined the structure of the 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous…”
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Selective inhibition of human translation termination by a drug-like compound by Li, Wenfei, Chang, Stacey Tsai-Lan, Ward, Fred. R., Cate, Jamie H. D.

“…Methods to directly inhibit gene expression using small molecules hold promise for the development of new therapeutics targeting proteins that have evaded…”
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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule by Li, Wenfei, Ward, Fred R., McClure, Kim F., Chang, Stacey Tsai-Lan, Montabana, Elizabeth, Liras, Spiros, Dullea, Robert G., Cate, Jamie H. D.

“…The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown…”
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Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition by Travin, Dmitrii Y., Watson, Zoe L., Metelev, Mikhail, Ward, Fred R., Osterman, Ilya A., Khven, Irina M., Khabibullina, Nelli F., Serebryakova, Marina, Mergaert, Peter, Polikanov, Yury S., Cate, Jamie H. D., Severinov, Konstantin

“…Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly expanding class of natural products with various biological activities…”
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Activity-Based DNA-Encoded Library Screening for Selective Inhibitors of Eukaryotic Translation by Barhoosh, Huda, Dixit, Anjali, Cochrane, Wesley G., Cavett, Valerie, Prince, Robin N., Blair, Brooke O., Ward, Fred R., McClure, Kim F., Patten, Phillip A., Paulick, Margot G., Paegel, Brian M.

“…Small molecule probes exist for only ∼2% of human proteins because most lack functional binding pockets or cannot be assayed for high-throughput screening…”
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Initiation of Protein Synthesis with Non‐Canonical Amino Acids In Vivo by Tharp, Jeffery M., Ad, Omer, Amikura, Kazuaki, Ward, Fred R., Garcia, Emma M., Cate, Jamie H. D., Schepartz, Alanna, Söll, Dieter

“…By transplanting identity elements into E. coli tRNAfMet, we have engineered an orthogonal initiator tRNA (itRNATy2) that is a substrate for Methanocaldococcus…”
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Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates by Watson, Zoe L., Knudson, Isaac J., Ward, Fred R., Miller, Scott J., Cate, Jamie H. D., Schepartz, Alanna, Abramyan, Ara M.

“…As genetic code expansion advances beyond l -α-amino acids to backbone modifications and new polymerization chemistries, delineating what substrates the…”
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Defects in the Assembly of Ribosomes Selected for β‑Amino Acid Incorporation by Ward, Fred R, Watson, Zoe L, Ad, Omer, Schepartz, Alanna, Cate, Jamie H. D

“…Ribosome engineering has emerged as a promising field in synthetic biology, particularly concerning the production of new sequence-defined polymers. Mutant…”
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Initiation of Protein Synthesis with Non‐Canonical Amino Acids In Vivo by Tharp, Jeffery M., Ad, Omer, Amikura, Kazuaki, Ward, Fred R., Garcia, Emma M., Cate, Jamie H. D., Schepartz, Alanna, Söll, Dieter

“…By transplanting identity elements into E. coli tRNAfMet, we have engineered an orthogonal initiator tRNA (itRNATy2) that is a substrate for Methanocaldococcus…”
Get full text