Search Results - "Ward, Dale E."

Enantioselective Total Synthesis of Cyathin A3 by Ward, Dale E, Shen, Jianheng

“…The total synthesis of (−)-cyathin A3 is described. The key step involves an unusual enantioselective Diels−Alder reaction of 2,5-dimethyl-1,4-benzoquinone…”
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Total Synthesis of Dolabriferol C by a Highly Stereoselective One‐Pot Coupling of a meso‐3,7‐Diketone with Two Chiral Aldehydes by Diddi, Naveen, Ward, Dale E.

“…Total synthesis of the noncontiguous polypropionate dolabriferol C was achieved by retro‐Claisen fragmentation of its putative contiguous precursor under mild…”
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Thiopyran Route to Polypropionates:  An Efficient Synthesis of Serricornin by Ward, Dale E, Jheengut, Vishal, Beye, Garrison E

“…The synthesis of serricornin [(4S,6S,7S)-7-hydroxy-4,6-dimethylnonan-3-one], a sex pheromone produced by the female cigarette beetle (Lasioderma serricorne…”
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Rational Design of Aldol Reactions That Proceed via Kinetic Resolution with Switchable Enantioselectivity by Ward, Dale E, Becerril-Jimenez, Fabiola, Zahedi, M. Mehdi

“…The stereoselectivity of aldol reactions of chiral reactants can be factorized into to three stereocontrol elements: the diastereoface selectivities of the…”
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Enantiospecific Total Synthesis of Lairdinol A by Pardeshi, Sandip G, Ward, Dale E

“…The synthesis of lairdinol A, a component of the host-selective phytotoxin depsilairdin, was achieved in 12 steps (18% overall yield) without the use of…”
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The Thiopyran Route to Polypropionates:  Enantioselective Synthesis of Membrenone B from Racemic Fragments by Jheengut, Vishal, Ward, Dale E

“…(6S,7S,8S,9R,10S)-(−)-Membrenone B was synthesized in nine steps (9.4% overall yield) beginning with two-directional aldol coupling of…”
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The thiopyran route to polypropionates by Ward, Dale E

“…The strategic use of thiopyran templates to facilitate polypropionate synthesis was first demonstrated in Woodward's landmark total synthesis of erythromycin A…”
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On the Origin of Dolabriferol: Total Synthesis via Its Putative Contiguous Precursor by Karagiannis, Athanasios, Diddi, Naveen, Ward, Dale E

“…The putative contiguous polypropionate precursor of dolabriferol was synthesized using as the key step a rationally designed enantiomer-selective aldol…”
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Intramolecular Diels−Alder Reaction by Self-Assembly of the Components on a Lewis Acid Template by Ward, Dale E, Abaee, Mohammad Saeed

“…Diels−Alder reactions of 2,4-hexadienol or its O-methyl ether with acrylate derivatives at 120 °C give mixtures of the four possible adducts with low…”
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Total Synthesis of Dolabriferol C by a Highly Stereoselective One‐Pot Coupling of a meso‐3,7‐Diketone with Two Chiral Aldehydes by Diddi, Naveen, Ward, Dale E.

“…Total synthesis of the noncontiguous polypropionate dolabriferol C was achieved by retro‐Claisen fragmentation of its putative contiguous precursor under mild…”
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Aldol Reactions with Kinetic Resolution: Scope and Limitations of Ketal- and Dithioketal-Protected β‑Ketoaldehydes by Ward, Dale E, Kazemeini, Alieh

“…The multiplicativity rule suggests that aldol coupling of chiral reactants will proceed with substantial mutual kinetic enantioselection (MKE) (racemic…”
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Thiopyran Route to Polypropionates:  Exploiting and Overcoming Double Stereodifferentiation and Mutual Kinetic Enantioselection in Aldol Couplings of Chiral Fragments by Ward, Dale E, Beye, Garrison E, Sales, Marcelo, Alarcon, Idralyn Q, Gillis, H. Martin, Jheengut, Vishal

“…The aldol reaction of tetrahydro-4H-thiopyranone with 1,4-dioxa-8-thiaspiro[4.5]decane-6-carboxaldehyde (I) gives four possible diastereomeric adducts (II)…”
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Asymmetric Synthesis of Hexapropionate Synthons by Sequential Enantiotopic Group Selective Enolization of Meso Diketones by Ward, Dale E, Gillis, H. Martin, Akinnusi, Olukayode T, Rasheed, M. Abdul, Saravanan, K, Sasmal, Pradip K

“…Meso 1,9-diketones (six to seven stereocenters) are readily obtained by stepwise or simultaneous two-directional aldol reactions of…”
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On the Origin of Siphonariid Polypropionates: Total Synthesis of Caloundrin B and Its Isomerization to Siphonarin B by Becerril-Jiménez, Fabiola, Ward, Dale E

“…Enantioselective synthesis of the enantiomer of caloundrin B was achieved by strategic aldol coupling of an enantiopure trioxaadamantane-containing ketone with…”
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A Systematic Study of the Effects of Relative Configuration, Protecting Group, and Enolate Type on the Diastereoselectivities of Aldol Reactions of a Chiral Ethyl Ketone with 2‑Methylpropanal by Ward, Dale E, Kundu, Diptarghya, Biniaz, Mojtaba, Jana, Sushital

“…The diastereoselectivities of aldol reactions of 2-methylpropanal with various enolates of 5-O-methoxymethyl and 5-O-triethylsilyl derivatives of the four…”
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On the Origin of Siphonariid Polypropionates: Total Synthesis of Baconipyrone A, Baconipyrone C, and Siphonarin B via their Putative Common Precursor by Beye, Garrison E, Ward, Dale E

“…The hypothesis that siphonariid polypropionates originate from nonenzymatic processes on acyclic biosynthetic precursors was tested by examining the properties…”
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A General Approach to Cyathin Diterpenes. Total Synthesis of Allocyathin B3 by Ward, Dale E, Gai, Yuanzhu, Qiao, Qi

“…The synthesis of allocyathin B3 from an advanced intermediate possessing the ring system and relative stereochemistry but lacking the isopropyl and…”
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Total Synthesis of Muamvatin by Ward, Dale E, Zahedi, M. Mehdi

“…Enantioselective total synthesis of muamvatin was achieved by ring-chain tautomerization of an acyclic derivative assembled by sequential substrate-controlled…”
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Synthetic studies on cyathin diterpenes - Total synthesis of (±)-allocyathin B3 by Ward, Dale E, Gai, Yuanzhu, Qiao, Qi, Shen, Jianheng

“…The synthesis of racemic allocyathin B 3 from an advanced intermediate possessing the ring system and relative stereochemistry but lacking the isopropyl and…”
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Enantioselective Direct Intermolecular Aldol Reactions with Enantiotopic Group Selectivity and Dynamic Kinetic Resolution by Ward, Dale E, Jheengut, Vishal, Akinnusi, Olukayode T

“…Proline-catalyzed aldol reactions of tetrahydro-4H-thipyranone with racemic 1,4-dioxa-8-thia-spiro[4.5]decane-6-carboxaldehyde and with meso/dl…”
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