Search Results - "Ward, Carl C"

Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots by Roberts, Allison M, Ward, Carl C, Nomura, Daniel K

“…Graphical abstract…”
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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation by Spradlin, Jessica N., Hu, Xirui, Ward, Carl C., Brittain, Scott M., Jones, Michael D., Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornelas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A., Bussiere, Dirksen E., Thomas, Jason R., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

“…Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide…”
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Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications by Ward, Carl C, Kleinman, Jordan I, Brittain, Scott M, Lee, Patrick S, Chung, Clive Yik Sham, Kim, Kenneth, Petri, Yana, Thomas, Jason R, Tallarico, John A, McKenna, Jeffrey M, Schirle, Markus, Nomura, Daniel K

“…Targeted protein degradation has arisen as a powerful strategy for drug discovery allowing the targeting of undruggable proteins for proteasomal degradation…”
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Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition by Chung, Clive Yik-Sham, Shin, Hijai R., Berdan, Charles A., Ford, Breanna, Ward, Carl C., Olzmann, James A., Zoncu, Roberto, Nomura, Daniel K.

“…Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for…”
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Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue by Ma, Jiao, Ward, Carl C, Jungreis, Irwin, Slavoff, Sarah A, Schwaid, Adam G, Neveu, John, Budnik, Bogdan A, Kellis, Manolis, Saghatelian, Alan

“…The existence of nonannotated protein-coding human short open reading frames (sORFs) has been revealed through the direct detection of their sORF-encoded…”
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Ligandability of E3 Ligases for Targeted Protein Degradation Applications by Belcher, Bridget P., Ward, Carl C., Nomura, Daniel K.

“…Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue degraders has arisen as a powerful therapeutic modality…”
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Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State by Magtanong, Leslie, Ko, Pin-Joe, To, Milton, Cao, Jennifer Yinuo, Forcina, Giovanni C, Tarangelo, Amy, Ward, Carl C, Cho, Kevin, Patti, Gary J, Nomura, Daniel K, Olzmann, James A, Dixon, Scott J

“…The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity…”
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NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots by Ward, Carl C, Kleinman, Jordan I, Nomura, Daniel K

“…Most of the proteome is considered undruggable, oftentimes hindering translational efforts for drug discovery. Identifying previously unknown druggable…”
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Deubiquitinase-targeting chimeras for targeted protein stabilization by Henning, Nathaniel J., Boike, Lydia, Spradlin, Jessica N., Ward, Carl C., Liu, Gang, Zhang, Erika, Belcher, Bridget P., Brittain, Scott M., Hesse, Matthew J., Dovala, Dustin, McGregor, Lynn M., Valdez Misiolek, Rachel, Plasschaert, Lindsey W., Rowlands, David J., Wang, Feng, Frank, Andreas O., Fuller, Daniel, Estes, Abigail R., Randal, Katelyn L., Panidapu, Anoohya, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

“…Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein…”
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Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products by Grossman, Elizabeth A, Ward, Carl C, Spradlin, Jessica N, Bateman, Leslie A, Huffman, Tucker R, Miyamoto, David K, Kleinman, Jordan I, Nomura, Daniel K

“…Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as…”
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Improving prime editing with an endogenous small RNA-binding protein by Yan, Jun, Oyler-Castrillo, Paul, Ravisankar, Purnima, Ward, Carl C., Levesque, Sébastien, Jing, Yangwode, Simpson, Danny, Zhao, Anqi, Li, Hui, Yan, Weihao, Goudy, Laine, Schmidt, Ralf, Solley, Sabrina C., Gilbert, Luke A., Chan, Michelle M., Bauer, Daniel E., Marson, Alexander, Parsons, Lance R., Adamson, Britt

“…Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs…”
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Base-editing mutagenesis maps alleles to tune human T cell functions by Schmidt, Ralf, Ward, Carl C., Dajani, Rama, Armour-Garb, Zev, Ota, Mineto, Allain, Vincent, Hernandez, Rosmely, Layeghi, Madeline, Xing, Galen, Goudy, Laine, Dorovskyi, Dmytro, Wang, Charlotte, Chen, Yan Yi, Ye, Chun Jimmie, Shy, Brian R., Gilbert, Luke A., Eyquem, Justin, Pritchard, Jonathan K., Dodgson, Stacie E., Marson, Alexander

“…CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell function and has nominated candidate targets for immunotherapies 1 –…”
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Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism by Pham, Vanha N, Bruemmer, Kevin J, Toh, Joel D W, Ge, Eva J, Tenney, Logan, Ward, Carl C, Dingler, Felix A, Millington, Christopher L, Garcia-Prieto, Carlos A, Pulos-Holmes, Mia C, Ingolia, Nicholas T, Pontel, Lucas B, Esteller, Manel, Patel, Ketan J, Nomura, Daniel K, Chang, Christopher J

“…One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a…”
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The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT–liver communication by Sponton, Carlos H, Hosono, Takashi, Taura, Junki, Jedrychowski, Mark P, Yoneshiro, Takeshi, Wang, Qiang, Takahashi, Makoto, Matsui, Yumi, Ikeda, Kenji, Oguri, Yasuo, Tajima, Kazuki, Shinoda, Kosaku, Pradhan, Rachana N, Chen, Yong, Brown, Zachary, Roberts, Lindsay S, Ward, Carl C, Taoka, Hiroki, Yokoyama, Yoko, Watanabe, Mitsuhiro, Karasawa, Hiroshi, Nomura, Daniel K, Kajimura, Shingo

“…While brown adipose tissue (BAT) is well‐recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in…”
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Discovery of Potent Pyrazoline‐Based Covalent SARS‐CoV‐2 Main Protease Inhibitors by Moon, Patrick, Zammit, Charlotte M., Shao, Qian, Dovala, Dustin, Boike, Lydia, Henning, Nathaniel J., Knapp, Mark, Spradlin, Jessica N., Ward, Carl C., Wolleb, Helene, Fuller, Daniel, Blake, Gabrielle, Murphy, Jason P., Wang, Feng, Lu, Yipin, Moquin, Stephanie A., Tandeske, Laura, Hesse, Matthew J., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Toste, F. Dean, Nomura, Daniel K.

“…While vaccines and antivirals are now being deployed for the current SARS‐CoV‐2 pandemic, we require additional antiviral therapeutics to not only effectively…”
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Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV‑2 by Biering, Scott B, Van Dis, Erik, Wehri, Eddie, Yamashiro, Livia H, Nguyenla, Xammy, Dugast-Darzacq, Claire, Graham, Thomas G. W, Stroumza, Julien R, Golovkine, Guillaume R, Roberts, Allison W, Fines, Daniel M, Spradlin, Jessica N, Ward, Carl C, Bajaj, Teena, Dovala, Dustin, Schulze-Gamen, Ursula, Bajaj, Ruchika, Fox, Douglas M, Ott, Melanie, Murthy, Niren, Nomura, Daniel K, Schaletzky, Julia, Stanley, Sarah A

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health…”
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