Search Results - "Ward, Adam R"

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1 by Sanz, Marta, Weideman, Ann Marie K., Ward, Adam R., Clohosey, Matthew L., Garcia-Recio, Susana, Selitsky, Sara R., Mann, Brendan T., Iannone, Marie Anne, Whitworth, Chloe P., Chitrakar, Alisha, Garrido, Carolina, Kirchherr, Jennifer, Coffey, Alisha R., Tsai, Yi- Hsuan, Samir, Shahryar, Xu, Yinyan, Copertino, Dennis, Bosque, Alberto, Jones, Brad R., Parker, Joel S., Hudgens, Michael G., Goonetilleke, Nilu, Soriano-Sarabia, Natalia

“…Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts…”
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HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy by Stevenson, Eva M, Ward, Adam R, Truong, Ronald, Thomas, Allison S, Huang, Szu-Han, Dilling, Thomas R, Terry, Sandra, Bui, John K, Mota, Talia M, Danesh, Ali, Lee, Guinevere Q, Gramatica, Andrea, Khadka, Pragya, Alberto, Winiffer D Conce, Gandhi, Rajesh T, McMahon, Deborah K, Lalama, Christina M, Bosch, Ronald J, Macatangay, Bernard, Cyktor, Joshua C, Eron, Joseph J, Mellors, John W, Jones, R Brad

“…Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses,…”
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The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells by Copertino, Jr, Dennis C, Holmberg, Carissa S, Weiler, Jared, Ward, Adam R, Howard, J Natalie, Levinger, Callie, Pang, Alina Ps, Corley, Michael J, Dündar, Friederike, Zumbo, Paul, Betel, Doron, Gandhi, Rajesh T, McMahon, Deborah K, Bosch, Ronald J, Linden, Noemi, Macatangay, Bernard J, Cyktor, Joshua C, Eron, Joseph J, Mellors, John W, Kovacs, Colin, Benko, Erika, Bosque, Alberto, Jones, R Brad

“…IL-15 is under clinical investigation toward the goal of curing HIV infection because of its abilities to reverse HIV latency and enhance immune effector…”
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Immunological approaches to HIV cure by Ward, Adam R., Mota, Talia M., Jones, R. Brad

“…•HIV infection persists despite antiviral responses and antiretroviral therapy.•Rare individuals can naturally control HIV infection by immune-mediated…”
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Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells by Huang, Szu-Han, Ren, Yanqin, Thomas, Allison S, Chan, Dora, Mueller, Stefanie, Ward, Adam R, Patel, Shabnum, Bollard, Catherine M, Cruz, Conrad Russell, Karandish, Sara, Truong, Ronald, Macedo, Amanda B, Bosque, Alberto, Kovacs, Colin, Benko, Erika, Piechocka-Trocha, Alicja, Wong, Hing, Jeng, Emily, Nixon, Douglas F, Ho, Ya-Chi, Siliciano, Robert F, Walker, Bruce D, Jones, R Brad

“…The presence of persistent, latent HIV reservoirs in CD4+ T cells obstructs current efforts to cure infection. The so-called kick-and-kill paradigm proposes to…”
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The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary TCM Cell Model of Latency by Sarabia, Indra, Huang, Szu-Han, Ward, Adam R, Jones, R. Brad, Bosque, Alberto

“…The establishment of HIV-1 latency has hindered an HIV-1 cure. “Shock and kill” strategies to target this reservoir aim to induce the latent provirus with…”
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The Index of Attitudes Toward Homosexuals: Factor Analysis in a National Sample of Oncology Clinicians by Pratt-Chapman, Mandi L., Ward, Adam R.

“…The Index of Attitudes toward Homosexuals (IAH) was published by Hudson and Ricketts in 1980 as a unidimensional index to measure affective responses to…”
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Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial by Gunst, Jesper D., Pahus, Marie H., Rosás-Umbert, Miriam, Lu, I-Na, Benfield, Thomas, Nielsen, Henrik, Johansen, Isik S., Mohey, Rajesh, Østergaard, Lars, Klastrup, Vibeke, Khan, Maryam, Schleimann, Mariane H., Olesen, Rikke, Støvring, Henrik, Denton, Paul W., Kinloch, Natalie N., Copertino, Dennis C., Ward, Adam R., Alberto, Winiffer D. Conce, Nielsen, Silke D., Puertas, Maria C., Ramos, Victor, Reeves, Jacqueline D., Petropoulos, Christos J., Martinez-Picado, Javier, Brumme, Zabrina L., Jones, R. Brad, Fox, Julie, Tolstrup, Martin, Nussenzweig, Michel C., Caskey, Marina, Fidler, Sarah, Søgaard, Ole S.

“…Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been…”
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Selective BCL-X L Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs by Ren, Yanqin, Huang, Szu Han, Macedo, Amanda B, Ward, Adam R, Alberto, Winiffer D Conce, Klevorn, Thais, Leyre, Louise, Copertino, Dennis C, Mota, Talia M, Chan, Dora, Truong, Ronald, Rohwetter, Thomas, Zumbo, Paul, Dündar, Friederike, Betel, Doron, Kovacs, Colin, Benko, Erika, Bosque, Alberto, Jones, R Brad

“…HIV persists, despite immune responses and antiretroviral therapy, in viral reservoirs that seed rebound viremia if therapy is interrupted. Previously, we…”
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Selective BCL-XL Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs by Ren, Yanqin, Huang, Szu Han, Macedo, Amanda B, Ward, Adam R, Alberto, Winiffer D. Conce, Klevorn, Thais, Leyre, Louise, Copertino, Dennis C, Mota, Talia M, Chan, Dora, Truong, Ronald, Rohwetter, Thomas, Zumbo, Paul, Dündar, Friederike, Betel, Doron, Kovacs, Colin, Benko, Erika, Bosque, Alberto, Jones, R. Brad

“…HIV persists, despite immune responses and antiretroviral therapy, in viral reservoirs that seed rebound viremia if therapy is interrupted. Previously, we…”
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SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells by Stevenson, Eva M., Terry, Sandra, Copertino, Dennis, Leyre, Louise, Danesh, Ali, Weiler, Jared, Ward, Adam R., Khadka, Pragya, McNeil, Evan, Bernard, Kevin, Miller, Itzayana G., Ellsworth, Grant B., Johnston, Carrie D., Finkelsztein, Eli J., Zumbo, Paul, Betel, Doron, Dündar, Friederike, Duncan, Maggie C., Lapointe, Hope R., Speckmaier, Sarah, Moran-Garcia, Nadia, Papa, Michelle Premazzi, Nicholes, Samuel, Stover, Carissa J., Lynch, Rebecca M., Caskey, Marina, Gaebler, Christian, Chun, Tae-Wook, Bosque, Alberto, Wilkin, Timothy J., Lee, Guinevere Q., Brumme, Zabrina L., Jones, R. Brad

“…Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8 + cytotoxic T-cells. Clinical studies of latency reversing…”
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No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART by Ward, Adam R., Thomas, Allison S., Stevenson, Eva M., Huang, Szu-Han, Keating, Sheila M., Gandhi, Rajesh T., McMahon, Deborah K., Bosch, Ronald J., Macatangay, Bernard J., Cyktor, Joshua C., Eron, Joseph J., Mellors, John W., Jones, R. Brad

“…People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific…”
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Relationships between Neutralization, Binding, and ADCC of Broadly Neutralizing Antibodies against Reservoir HIV by Ren, Yanqin, Korom, Maria, Ward, Adam R, Truong, Ronald, Chan, Dora, Huang, Szu-Han, Kovacs, Colin M, Benko, Erika, Safrit, Jeffrey T, Lee, John, Garbán, Hermes, Lynch, Rebecca, Jones, R Brad

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A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies by McCann, Chase D, van Dorp, Christiaan H, Danesh, Ali, Ward, Adam R, Dilling, Thomas R, Mota, Talia M, Zale, Elizabeth, Stevenson, Eva M, Patel, Shabnum, Brumme, Chanson J, Dong, Winnie, Jones, Douglas S, Andresen, Thomas L, Walker, Bruce D, Brumme, Zabrina L, Bollard, Catherine M, Perelson, Alan S, Irvine, Darrell J, Jones, R Brad

“…HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune…”
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Provider Recommendations Are Associated with Cancer Screening of Transgender and Gender-Nonconforming People: A Cross-Sectional Urban Survey by Pratt-Chapman, Mandi L., Ward, Adam R.

“…Purpose: This study examined the relationship between clinician recommendation and receipt of cancer screenings among a transgender and gender-nonconforming…”
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OP 1.9 – 00042 Measuring the impact of early 3BNC117 intervention at ART initiation on the productive reservoir in a cohort of diverse viral subtypes: results from the VIP-SPOT assay in the eCLEAR trial by M.C. Puertas, J.D. Gunst, M.H. Pahus, N.N. Kinloch, D.C. Copertino, Adam R. Ward, Z.L. Brumme, R. Brad Jones, M. Tolstrup, S. Fidler, O.S. Søgaard, J. Martinez-Picado

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Dynamics of HIV-specific T cells on long-term ART differ by antigen recognised and by sex by Eva M. Stevenson, Adam R. Ward, Thomas R. Dilling, John K. Bui, John Mellors, Rajesh Gandhi, Deborah McMahon, Joseph Eron, Ronald Bosch, Christina Lalama, Joshua Cyktor, Brad Jones

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The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary T CM Cell Model of Latency by Sarabia, Indra, Huang, Szu-Han, Ward, Adam R., Jones, R. Brad, Bosque, Alberto

“…HIV-1 establishes a latent reservoir that persists under antiretroviral therapy. Antiretroviral therapy is able to stop the spread of the virus and the…”
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Study on HIV Reservoir Size, HIV-Specific Immune Response Trends, and Inflammation, and Their Relationships, in People Living with HIV on Long-Term Antiretroviral Therapy by Ward, Adam R

“…Analysis 1: HIV persists in a reservoir of infected cells in people living with HIV (PLWH), necessitating lifelong antiretroviral therapy (ART) to prevent…”
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No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART by Ward, Adam R., Thomas, Allison S., Stevenson, Eva M., Huang, Szu-Han, Keating, Sheila M., Gandhi, Rajesh T., McMahon, Deborah K., Bosch, Ronald J., Macatangay, Bernard J., Cyktor, Joshua C., Eron, Joseph J., Mellors, John W., Jones, R. Brad

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