Search Results - "Warby, S C"

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study by Gottlieb, D J, Hek, K, Chen, T-h, Watson, N F, Eiriksdottir, G, Byrne, E M, Cornelis, M, Warby, S C, Bandinelli, S, Cherkas, L, Evans, D S, Grabe, H J, Lahti, J, Li, M, Lehtimäki, T, Lumley, T, Marciante, K D, Pérusse, L, Psaty, B M, Robbins, J, Tranah, G J, Vink, J M, Wilk, J B, Stafford, J M, Bellis, C, Biffar, R, Bouchard, C, Cade, B, Curhan, G C, Eriksson, J G, Ewert, R, Ferrucci, L, Fülöp, T, Gehrman, P R, Goodloe, R, Harris, T B, Heath, A C, Hernandez, D, Hofman, A, Hottenga, J-J, Hunter, D J, Jensen, M K, Johnson, A D, Kähönen, M, Kao, L, Kraft, P, Larkin, E K, Lauderdale, D S, Luik, A I, Medici, M, Montgomery, G W, Palotie, A, Patel, S R, Pistis, G, Porcu, E, Quaye, L, Raitakari, O, Redline, S, Rimm, E B, Rotter, J I, Smith, A V, Spector, T D, Teumer, A, Uitterlinden, A G, Vohl, M-C, Widen, E, Willemsen, G, Young, T, Zhang, X, Liu, Y, Blangero, J, Boomsma, D I, Gudnason, V, Hu, F, Mangino, M, Martin, N G, O'Connor, G T, Stone, K L, Tanaka, T, Viikari, J, Gharib, S A, Punjabi, N M, Räikkönen, K, Völzke, H, Mignot, E, Tiemeier, H

“…Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the…”
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0120 Emulating Human Sleep Spindle Scoring by Lacourse, K, Delfrate, J, Beaudry, J, Warby, S C

“…Abstract Introduction Sleep spindles are a marker of stage 2 NREM sleep, have been linked to the process of learning & memory, and are altered by many…”
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Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments by Warby, Simon C., Doty, Crystal N., Graham, Rona K., Shively, Jonathan, Singaraja, Roshni R., Hayden, Michael R.

“…Huntingtin is phosphorylated on serine-421 (S421) by the pro-survival signaling protein kinases Akt and SGK. Phosphorylation of huntingtin at S421 is variable…”
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A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease by Bečanović, Kristina, Nørremølle, Anne, Neal, Scott J, Kay, Chris, Collins, Jennifer A, Arenillas, David, Lilja, Tobias, Gaudenzi, Giulia, Manoharan, Shiana, Doty, Crystal N, Beck, Jessalyn, Lahiri, Nayana, Portales-Casamar, Elodie, Warby, Simon C, Connolly, Colúm, De Souza, Rebecca A G, Tabrizi, Sarah J, Hermanson, Ola, Langbehn, Douglas R, Hayden, Michael R, Wasserman, Wyeth W, Leavitt, Blair R

“…Huntington disease (HD) is an incurable neurodegenerative disease. A SNP in the huntingtin promoter impaired NF-κB binding and acted as a bidirectional…”
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Selective degeneration in YAC mouse models of Huntington disease by Van Raamsdonk, Jeremy M, Warby, Simon C, Hayden, Michael R

“…Abstract Huntington disease (HD) is one of at least nine polyglutamine disorders caused by a CAG expansion in the coding region of a disease-causing gene…”
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Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo by Warby, Simon C., Chan, Edmond Y., Metzler, Martina, Gan, Lu, Singaraja, Roshni R., Crocker, Susan F., Robertson, Harold A., Hayden, Michael R.

“…Huntington disease (HD) results from polyglutamine expansion in the huntingtin protein (htt). Despite the widespread tissue expression pattern of htt, neuronal…”
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