Search Results - "Warburton, Michael J."

Human breast cancer cell lines and tissues express tartrate-resistant acid phosphatase (TRAP) by Adams, Lisa M., Warburton, Michael J., Hayman, Alison R.

“…Tartrate-resistant acid phosphatase (TRAP) is expressed by osteoclasts, macrophages and dendritic cells. TRAP has been identified in a wide variety of tissues,…”
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Lysosomal degradation of cholecystokinin-(29-33)-amide in mouse brain is dependent on tripeptidyl peptidase-I: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis by Bernardini, Francesca, Warburton, Michael J

“…Tripeptidyl peptidase-I (TPP-I) is a lysosomal exopeptidase which removes tripeptides from the N-terminus of small peptides. Mutations in the TPP-I gene result…”
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Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I by Vines, David J, Warburton, Michael J

“…Tripeptidyl peptidase I (TPP-I) is a lysosomal enzyme that cleaves tripeptides from the N-terminus of polypeptides. A comparison of TPP-I amino acid sequences…”
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The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis by Kopan, Sharmila, Sivasubramaniam, Uthayatharsini, Warburton, Michael J

“…Late-infantile neuronal ceroid lipofuscinosis (CLN2), previously known as the late-infantile form of Batten disease, is a lysosomal storage disease which…”
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Tripeptidyl peptidase-I is essential for the degradation of sulphated cholecystokinin-8 (CCK-8S) by mouse brain lysosomes by Warburton, Michael J, Bernardini, Francesca

“…Tripeptidyl peptidase-I (TPP-I) is a lysosomal exopeptidase which removes tripeptides from the N-terminus of small proteins. Mutations in the TPP-I gene result…”
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The specificity of lysosomal tripeptidyl peptidase-I determined by its action on angiotensin-II analogues by Warburton, Michael J, Bernardini, Francesca

“…Tripeptidyl peptidase-I (TPP-I) is a lysosomal peptidase which cleaves tripeptides from the N-terminus of peptides. The function of the enzyme is unclear but…”
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Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen by Vines, David, Warburton, Michael J

“…A tripeptidyl aminopeptidase I with an M r of 47,000 Da has been purified from rat spleen. The N-terminal sequence of the enzyme and internal sequences did not…”
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Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases by Gusterson, B A, Warburton, M J, Mitchell, D, Ellison, M, Neville, A M, Rudland, P S

“…An immunocytochemical method for fixed and paraffin-embedded human breast biopsies is reported for the detection of myoepithelial and epithelial cells using…”
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Ectoenzyme regulation by phenotypically distinct fibroblast sub-populations isolated from the human mammary gland by Atherton, A J, O'Hare, M J, Buluwela, L, Titley, J, Monaghan, P, Paterson, H F, Warburton, M J, Gusterson, B A

“…Inter- and intralobular mammary fibroblasts have been separated from normal human breast tissue and cultured to study the differential expression of…”
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Dipeptidyl peptidase IV expression identifies a functional sub-population of breast fibroblasts by Atherton, A J, Monaghan, P, Warburton, M J, Robertson, D, Kenny, A J, Gusterson, B A

“…The immunocytochemical distribution of the cell-surface enzyme dipeptidyl peptidase IV (DPP IV) has been studied in the human breast at the light and…”
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Human osteoclastomas contain multiple forms of cathepsin B by Page, A E, Warburton, M J, Chambers, T J, Pringle, J A, Hayman, A R

“…During bone resorption, the osteoclast secretes hydrolytic enzymes into the sealing zone which it creates between itself and the bone surface. Since this…”
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Loss of production of myoepithelial cells and basement membrane proteins but retention of response to certain growth factors and hormones by a new malignant human breast cancer cell strain by RUDLAND, P. S, HALLOWES, R. C, COX, S. A, ORMEROD, E. J, WARBURTON, M. J

“…Digestion of primary breast cancers and their metastases with collagenase yields cell clusters which can be selectively isolated from stromal cells and from…”
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Two forms of tumors in nude mice generated by a neoplastic rat mammary stem cell line by Rudland, P S, Gusterson, B A, Hughes, C M, Ormerod, E J, Warburton, M J

“…The rat mammary (Rama) epithelial stem cell line Rama 25, isolated from a dimethylbenz[a]anthracene-induced tumor, differentiates in culture into elongated…”
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Immunocytochemical demonstration of hormonally regulable casein in tumors produced by a rat mammary stem cell line by RUDLAND, P. S, HUGHES, C. M, DAVIES, A. C. T, WARBURTON, M. J

“…The rat mammary epithelial stem cell line, Rat Mammary 25, and the dimethyl sulfoxide-resistant variant derived from it, Rama 259, when injected separately…”
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Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I 1 by Vines, David J, Warburton, Michael J

“…Tripeptidyl peptidase I (TPP‐I) is a lysosomal enzyme that cleaves tripeptides from the N‐terminus of polypeptides. A comparison of TPP‐I amino acid sequences…”
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The substrate range of tripeptidyl-peptidase I by Bernardini, Francesca, Warburton, Michael J.

“…Tripeptidyl-peptidase I (TPP-I) is an exopeptidase which removes tripeptides from the N-terminus of peptides.Mutations in TPP-I are responsible for late…”
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Extracellular matrix control of collagen production by rat mammary epithelial and myoepithelial-like cells in vitro by Warburton, M J, Ferns, S A, Hughes, C M

“…A rat mammary myoepithelial cell line (Rama 401) grown on plastic produces 5 times more collagen (largely type IV) than a mammary epithelial cell line (Rama…”
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Intracellular degradation of type I collagen and fibronectin in human lung fibroblasts: evidence against degradation in pre-lysosomal compartments by Monica, L., Andersson, B., Warburton, Michael J.

“…Fibroblasts degrade about 15% of newly synthesised collagen within the cell before it can be secreted. When the helical structure of collagen is disrupted,…”
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Differential expression of type XIV collagen/undulin by human mammary gland intralobular and interlobular fibroblasts by Atherton, A J, Warburton, M J, O'Hare, M J, Monaghan, P, Schuppan, D, Gusterson, B A

“…Immunolocalisation of type XIV collagen/undulin in the human mammary gland revealed greater deposition in the interlobular stroma than in the intralobular…”
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Regulation of Urokinase-Type Plasminogen Activator Production by Rat Mammary Myoepithelial Cells by Warburton, Michael J., Dundas, Sinclair R., Gusterson, Barry A., O'Hare, Michael J.

“…Addition of basic fibroblast growth factor (bFGF) to a rat mammary gland myoepithelial cell line (25.5−G4.2.3) resulted in a six- to eightfold increase in…”
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