Search Results - "Wanstall, Janet C"

Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension by Jeffery, Trina K, Wanstall, Janet C

“…Pulmonary vascular remodelling is an important pathological feature of pulmonary hypertension, leading to increased pulmonary vascular resistance and reduced…”
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Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors by Doggrell, Sheila A, Wanstall, Janet C

“…On release from cardiac mast cells, alpha-chymase converts angiotensin I (Ang I) to Ang II. In addition to Ang II formation, alpha-chymase is capable of…”
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Alterations in pulmonary vascular function in rats exposed to intermittent hypoxia by Thomas, Bronwyn J., Wanstall, Janet C.

“…Vasoactive agents were examined in arteries from control rats and rats exposed to intermittent hypoxia (10% oxygen; 8 h/day) for 3, 5 or 20 days. Hypoxic rats…”
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Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate by Homer, Kerry L, Wanstall, Janet C

“…Inhibition of rat platelet aggregation by the nitric oxide (NO) donor MAHMA NONOate (Z‐1‐{N‐methyl‐N‐[6‐(N‐methylammoniohexyl)amino]}diazen‐1‐ium‐1,2‐diolate)…”
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Cyclic GMP‐independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor by Homer, Kerry L, Wanstall, Janet C

“…In rat pulmonary artery pre‐contracted with phenylephrine, the mechanisms of relaxation to the nitric oxide (NO) donor, spermine NONOate, were investigated…”
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Proteinase-activated receptor (PAR)-mediated vasorelaxation in pulmonary arteries from normotensive and hypoxic pulmonary hypertensive rats by Wanstall, Janet C, Gambino, A

“…Proteinase-activated receptor (PAR)-mediated vasorelaxant responses were examined in main pulmonary artery preparations from control rats and rats exposed to…”
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Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function by Jeffery, Trina K, Wanstall, Janet C

“…Hypoxic pulmonary hypertension in rats (10% O2, 4 weeks) is characterized by changes in pulmonary vascular structure and function. The effects of the…”
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Vascular chymase: pathophysiological role and therapeutic potential of inhibition by DOGGRELL, Sheila A, WANSTALL, Janet C

“…Chymase is a chymotrypsin-like serine protease secreted from mast cells. Mammalian chymases are classified into two subgroups (alpha and beta) according to…”
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Vascular smooth muscle relaxation mediated by nitric oxide donors : a comparison with acetylcholine, nitric oxide and nitroxyl ion by WANSTALL, Janet C, JEFFERY, Trina K, GAMBINO, Agatha, LOVREN, Fina, TRIGGLE, Christopher R

“…1. Vasorelaxant properties of three nitric oxide (NO) donor drugs (glyceryl trinitrate, sodium nitroprusside and spermine NONOate) in mouse aorta…”
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Evidence for, and importance of, cGMP-independent mechanisms with NO and NO donors on blood vessels and platelets by Wanstall, Janet C, Homer, Kerry L, Doggrell, Sheila A

“…In the vasculature it is well established that cGMP is involved in the relaxant response to nitric oxide (NO) and NO donors. However, there is an increasing…”
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Nitric oxide donors inhibit 5‐hydroxytryptamine (5‐HT) uptake by the human 5‐HT transporter (SERT) by Bryan‐Lluka, Lesley J, Papacostas, Marisa H, Paczkowski, Filip A, Wanstall, Janet C

“…The aim was to test the hypothesis that nitric oxide (NO) donor drugs can inhibit the 5‐hydroxytryptamine (5‐HT) transporter, SERT. The NO donors, MAHMA/NO (a…”
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Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension by WANSTALL, Janet C, GAMBINO, Agatha, JEFFERY, Trina K, CAHILL, Marian M, BELLOMO, Daniela, HAYWARD, Nicholas K, KAY, Graham F

“…To test the hypothesis that Vegf-B contributes to the pulmonary vascular remodelling, and the associated pulmonary hypertension, induced by exposure of mice to…”
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S‐Nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats by Tsui, Debbie Y Y, Gambino, Agatha, Wanstall, Janet C

“…On rat isolated pulmonary arteries, vasorelaxation by S‐nitrosocaptopril (SNOcap) was compared with S‐nitrosoglutathione (GSNO) and nitroprusside, and…”
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Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats by Homer, Kerry L, Wanstall, Janet C

“…The platelet inhibitory effects of the nitric oxide (NO) donor drug MAHMA NONOate (( Z-1-{ N-methyl- N-[6-(…”
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Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders? by Doggrell, Sheila A, Wanstall, Janet C

“…Chymase is contained in the secretory granules of mast cells. In addition to the synthesis of angiotensin II, chymase is involved in transforming growth…”
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Pulmonary vascular remodelling in hypoxic rats: effects of amlodipine, alone and with perindopril by Jeffery, Trina K., Wanstall, Janet C.

“…This study investigated whether pulmonary vascular remodelling in hypoxic pulmonary hypertensive rats (10% oxygen; 4 weeks) could be prevented by treatment,…”
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Potentiation of 5-hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia by Wanstall, Janet C, Fiore, Steven A, Gambino, Agatha, Chess-Williams, Russell

“…The aim was to determine whether uptake of 5-hydroxytryptamine (5-HT) by the 5-HT transporter (SERT) modulates contractile responses to 5-HT in rat pulmonary…”
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S-Nitrosocaptopril: acute in-vivo pulmonary vasodepressor effects in pulmonary hypertensive rats by Tsui, Debbie Y. Y., Gambino, Agatha, Wanstall, Janet C.

“…The effects of S‐nitrosocaptopril (SNOcap), administered either intravenously or by oral gavage, on pulmonary artery pressure (PAP) were examined in…”
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Phosphodiesterase III and V Inhibitors on Pulmonary Artery from Pulmonary Hypertensive Rats: Differences Between Early and Established Pulmonary Hypertension by Jeffery, Trina K, Wanstall, Janet C

“…Milrinone and 6-bromo-8(methylamino)imidazo[1,2a]pyrazine-2-carbonitrile [SCA40; phosphodiesterase (PDE) III inhibitors], zaprinast (PDE V inhibitor), and…”
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The in vitro pulmonary vascular effects of FK409 (nitric oxide donor): a study in normotensive and pulmonary hypertensive rats by Wanstall, Janet C, Kaye, Jacqueline A, Gambino, Agatha

“…Vasorelaxant responses to the nitric oxide (NO) donor, FK409 ((±)‐(E)‐4‐ethyl‐2‐[(E)‐hydroxyimino]‐5‐nitro‐3‐hexenamide), were evaluated on precontracted…”
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