Search Results - "Wanner, Laura M"

Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors by Nuss, Jonathan E, Kehn-Hall, Kylene, Benedict, Ashwini, Costantino, Julie, Ward, Michael, Peyser, Brian D, Retterer, Cary J, Tressler, Lyal E, Wanner, Laura M, McGovern, Hugh F, Zaidi, Anum, Anthony, Scott M, Kota, Krishna P, Bavari, Sina, Hakami, Ramin M

“…Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV). Infection with RVFV in ruminants can…”
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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays by Kiris, Erkan, Nuss, Jonathan E, Stanford, Stephanie M, Wanner, Laura M, Cazares, Lisa, Maestre, Michael F, Du, Hao T, Gomba, Glenn Y, Burnett, James C, Gussio, Rick, Bottini, Nunzio, Panchal, Rekha G, Kane, Christopher D, Tessarollo, Lino, Bavari, Sina

“…There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts…”
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Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors by Ruthel, Gordon, Burnett, James C, Nuss, Jonathan E, Wanner, Laura M, Tressler, Lyal E, Torres-Melendez, Edna, Sandwick, Sarah J, Retterer, Cary J, Bavari, Sina

“…Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in…”
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Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons by Kiris, Erkan, Burnett, James C., Nuss, Jonathan E., Wanner, Laura M., Peyser, Brian D., Du, Hao T., Gomba, Glenn Y., Kota, Krishna P., Panchal, Rekha G., Gussio, Rick, Kane, Christopher D., Tessarollo, Lino, Bavari, Sina

“…Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no…”
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Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery by Kiris, Erkan, Nuss, Jonathan E, Burnett, James C, Kota, Krishna P, Koh, Dawn C, Wanner, Laura M, Torres-Melendez, Edna, Gussio, Rick, Tessarollo, Lino, Bavari, Sina

“…Botulinum neurotoxins (BoNTs) inhibit cholinergic synaptic transmission by specifically cleaving proteins that are crucial for neurotransmitter exocytosis. Due…”
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A high content imaging assay for identification of Botulinum neurotoxin inhibitors by Kota, Krishna P, Soloveva, Veronica, Wanner, Laura M, Gomba, Glenn, Kiris, Erkan, Panchal, Rekha G, Kane, Christopher D, Bavari, Sina

“…Synaptosomal-associated protein-25 (SNAP-25) is a component of the soluble NSF attachment protein receptor (SNARE) complex that is essential for synaptic…”
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The osmolyte trimethylamine N-oxide (TMAO) increases the proteolytic activity of botulinum neurotoxin light chains A, B, and E: implications for enhancing analytical assay sensitivity by Nuss, Jonathan E, Wanner, Laura M, Tressler, Lyal E, Bavari, Sina

“…Botulism, the disease caused by botulinum neurotoxins (BoNTs), secreted by the spore-forming, anaerobic bacteria Clostridium botulinum, has been associated…”
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Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies by Nuss, Jonathan E, Ruthel, Gordon, Tressler, Lyal E, Wanner, Laura M, Torres-Melendez, Edna, Hale, Martha L, Bavari, Sina

“…Botulinum neurotoxins (BoNTs) are zinc-metalloproteases that cleave components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein…”
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Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors by Nuss, Jonathan E, Dong, Yuxiang, Wanner, Laura M, Ruthel, Gordon, Wipf, Peter, Gussio, Rick, Vennerstrom, Jonathan L, Bavari, Sina, Burnett, James C

“…Botulinum neurotoxins (BoNTs) are the deadliest of microbial toxins. The enzymes’ zinc(II) metalloprotease, referred to as the light chain (LC) component,…”
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203. Development of an electrochemiluminescent assay to support high-throughput screening for botulinum neurotoxin serotype A (BoNT/A) inhibitors by Wanner, Laura M., Gomba, Glenn Y., Soloveva, Veronica, Kane, Christopher, Bavari, Sina

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A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors by Kota, Krishna P., Soloveva, Veronica, Wanner, Laura M., Gomba, Glenn, Kiris, Erkan, Panchal, Rekha G., Kane, Christopher D., Bavari, Sina

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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays: e0129264 by Kiris, Erkan, Nuss, Jonathan E, Stanford, Stephanie M, Wanner, Laura M, Cazares, Lisa, Maestre, Michael F, Du, Hao T, Gomba, Glenn Y, Burnett, James C, Gussio, Rick

“…There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts…”
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Multi-Faceted Proteomic Characterization of Host Protein Complement of Rift Valley Fever Virus Virions and Identification of Specific Heat Shock Proteins, Including HSP90, as Important Viral Host Factors: e93483 by Nuss, Jonathan E, Kehn-Hall, Kylene, Benedict, Ashwini, Costantino, Julie, Ward, Michael, Peyser, Brian D, Retterer, Cary J, Tressler, Lyal E, Wanner, Laura M, McGovern, Hugh F

“…Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV). Infection with RVFV in ruminants can…”
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Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease by Nuss, Jonathan E, Dong, Yuxiang, Wanner, Laura M, Ruthel, Gordon, Wipf, Peter, Gussio, Rick, Vennerstrom, Jonathan L, Bavari, Sina, Burnett, James C

“…Botulinum neurotoxins (BoNTs) are the deadliest of microbial toxins. The enzymes' Zinc(II) metalloprotease, referred to as the light chain (LC) component,…”
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