Search Results - "Wann, Angus K. T."

Primary cilia mediate mechanotransduction through control of ATP‐induced Ca2+ signaling in compressed chondrocytes by Wann, Angus K. T., Zuo, Ning, Haycraft, Courtney J., Jensen, Cynthia G., Poole, C. Anthony, McGlashan, Susan R., Knight, Martin M.

“…We investigated the role of the chondrocyte primary cilium in mechanotransduction events related to cartilage extracellular matrix synthesis. We generated…”
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Mechanoadaptation: articular cartilage through thick and thin by Vincent, Tonia L., Wann, Angus K. T.

“…The articular cartilage is exquisitely sensitive to mechanical load. Its structure is largely defined by the mechanical environment and destruction in…”
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Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation by Wann, Angus K T, Mistry, Jiten, Blain, Emma J, Michael-Titus, Adina T, Knight, Martin M

“…In inflammatory joint disease, such as osteoarthritis (OA), there is an increased level of proinflammatory cytokines, such as interleukin (IL)-1β. These…”
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Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice by Coveney, Clarissa R., Zhu, Linyi, Miotla‐Zarebska, Jadwiga, Stott, Bryony, Parisi, Ida, Batchelor, Vicky, Duarte, Claudia, Chang, Emer, McSorley, Eleanor, Vincent, Tonia L., Wann, Angus K. T.

“…Objective Mechanical and biologic cues drive cellular signaling in cartilage development, health, and disease. Primary cilia proteins, which are implicated in…”
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Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia by Mc Fie, Megan, Koneva, Lada, Collins, Isabella, Coveney, Clarissa R, Clube, Aisling M, Chanalaris, Anastasios, Vincent, Tonia L, Bezbradica, Jelena S, Sansom, Stephen N, Wann, Angus K T

“…Complex inflammatory signalling cascades define the response to tissue injury but also control development and homeostasis, limiting the potential for these…”
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Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP‐1–mediated endocytosis by Coveney, Clarissa R., Collins, Isabella, Fie, Megan Mc, Chanalaris, Anastasios, Yamamoto, Kazuhiro, Wann, Angus K. T.

“…ABSTRACT Matrix protease activity is fundamental to developmental tissue patterning and remains influential in adult homeostasis. In cartilage, the principal…”
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Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces by Coveney, Clarissa R, Samvelyan, Hasmik J, Miotla‐Zarebska, Jadwiga, Carnegie, Josephine, Chang, Emer, Corrin, C Jonty, Coveney, Trystan, Stott, Bryony, Parisi, Ida, Duarte, Claudia, Vincent, Tonia L, Staines, Katherine A, Wann, Angus KT

“…ABSTRACT Compared with our understanding of endochondral ossification, much less is known about the coordinated arrest of growth defined by the narrowing and…”
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Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β by Thompson, Clare L, Patel, Riana, Kelly, Terri-Ann N, Wann, Angus K T, Hung, Clark T, Chapple, J Paul, Knight, Martin M

“…In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13…”
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Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics by Singer, Donald, Thamm, Kristina, Zhuang, Heng, Karbanová, Jana, Gao, Yan, Walker, Jemma Victoria, Jin, Heng, Wu, Xiangnan, Coveney, Clarissa R, Marangoni, Pauline, Lu, Dongmei, Grayson, Portia Rebecca Clare, Gulsen, Tulay, Liu, Karen J, Ardu, Stefano, Wann, Angus KT, Luo, Shouqing, Zambon, Alexander C, Jetten, Anton M, Tredwin, Christopher, Klein, Ophir D, Attanasio, Massimo, Carmeliet, Peter, Huttner, Wieland B, Corbeil, Denis, Hu, Bing

“…Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is…”
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Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling by Ariosa-Morejon, Yoanna, Santos, Alberto, Fischer, Roman, Davis, Simon, Charles, Philip, Thakker, Rajesh, Wann, Angus KT, Vincent, Tonia L

“…Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo…”
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Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1[beta] by Thompson, Clare L, Patel, Riana, Kelly, Terri-Ann N, Wann, Angus K. T, Hung, Clark T, Chapple, J. Paul, Knight, Ma

“…Background In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading…”
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Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1Beta by Thompson, Clare L, Patel, Riana, Kelly, Terri-Ann N, Wann, Angus K T, Hung, Clark T, Chapple, J Paul, Knight, Martin M

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Primary cilia mediate mechanotransduction through control of ATP‐induced Ca 2+ signaling in compressed chondrocytes by Wann, Angus K. T., Zuo, Ning, Haycraft, Courtney J., Jensen, Cynthia G., Poole, C. Anthony, McGlashan, Susan R., Knight, Martin M.

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The role and uses of antibodies in COVID-19 infections: a living review by Scourfield, D Oliver, Reed, Sophie G, Quastel, Max, Alderson, Jennifer, Bart, Valentina M T, Teijeira Crespo, Alicia, Jones, Ruth, Pring, Ellie, Richter, Felix Clemens, Burnell, Stephanie E A

“…Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current…”
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Mucosal immune responses in COVID19 - a living review by Pearson, Claire F, Jeffery, Rebecca, Thornton, Emily E

“…COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many…”
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Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1[beta]-mediated cartilage degradation by Wann, Angus KT, Mistry, Jiten, Blain, Emma J, Michael-Titus, Adina T, Knight, Ma

“…Introduction In inflammatory joint disease, such as osteoarthritis (OA), there is an increased level of proinflammatory cytokines, such as interleukin…”
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Interleukin-1[beta] sequesters hypoxia inducible factor 2[alpha] to the primary cilium by Wann, Angus KT, Thompson, Clare L, Chapple, J Paul, Knight, Martin M

“…The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response…”
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