Search Results - "Wanibuchi, Fumikazu"

Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics by Nagakura, Yukinori, Okada, Masamichi, Kohara, Atsuyuki, Kiso, Tetsuo, Toya, Takashi, Iwai, Akihiko, Wanibuchi, Fumikazu, Yamaguchi, Tokio

“…The complete Freund's adjuvant (CFA)-induced arthritic rat model has extensively served as a laboratory model in the study of arthritic pain. However, the time…”
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Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist by Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Maeno, Kyoichi, Shimada, Itsuro, Koakutsu, Akiko, Wanibuchi, Fumikazu, Yamaguchi, Tokio

“…YM348, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine, showed a high affinity for cloned human 5-HT2C receptors (Ki: 0.89 nM). The functional…”
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Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists by SHIMADA, Itsuro, MAENO, Kyoichi, TSUKAMOTO, Shin-Ichi, KONDOH, Yutaka, KAKU, Hidetaka, SUGASAWA, Keizo, KIMURA, Yasuharu, HATANAKA, Ken-Ichi, NAITOU, Yuki, WANIBUCHI, Fumikazu, SAKAMOTO, Shuichi

“…To identify potent and selective 5-HT(2C) receptor agonists, a series of novel benzazepine derivatives were synthesized, and their structure-activity…”
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5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats by Kimura, Yasuharu, Naitou, Yuki, Wanibuchi, Fumikazu, Yamaguchi, Tokio

“…5-Hydroxytryptamine (5-HT), dopamine, oxytocin and melanocortin pathways are known to be involved in the induction of penile erections in rats. Although a…”
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5-HT2C receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats by Kimura, Yasuharu, Naitou, Yuki, Wanibuchi, Fumikazu, Yamaguchi, Tokio

“…5-Hydroxytryptamine (5-HT), dopamine, oxytocin and melanocortin pathways are known to be involved in the induction of penile erections in rats. Although a…”
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Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists by Shimada, Itsuro, Maeno, Kyoichi, Kazuta, Ken-ichi, Kubota, Hideki, Kimizuka, Tetsuya, Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Wanibuchi, Fumikazu, Sakamoto, Shuichi, Tsukamoto, Shin-ichi

“…A series of novel indazole derivatives were synthesized, and their structure-activity relationships examined in order to identify potent and selective 5-HT2C…”
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Synthesis and Structure-Activity Studies of a Series of 1-Oxa-2, 8-diazaspiro[4.5]decan-3-ones and Related Compounds as M1 Muscarinic Agonists by TSUKAMOTO, Shin-ichi, NAGAOKA, Hitoshi, IGARASHI, Susumu, WANIBUCHI, Fumikazu, HIDAKA, Kazuyuki, TAMURA, Toshinari

“…A series of novel 2, 8-dialykl-1-oxa-2, 8-diazaspiro[4.5]decan-3-ones and 2, 8-dimethyl-1, 2, 8-triazaspiro[4.5]-decan-3-one (13), related to M1 muscarinic…”
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Characterization of intracavernous pressure increase induced by Ym348, a novel 5-HT2C receptor agonist, in anesthetized rats by Kimura, Yasuharu, Naitou, Yuki, Wanibuchi, Fumikazu, Yamaguchi, Tokio

“…We investigated the effects of the novel 5-HT2C receptor agonist YM348 [(S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine] on ICP in anesthetized…”
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Synthesis and structure–activity relationships of a series of benzazepine derivatives as 5-HT 2C receptor agonists by Shimada, Itsuro, Maeno, Kyoichi, Kondoh, Yutaka, Kaku, Hidetaka, Sugasawa, Keizo, Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Wanibuchi, Fumikazu, Sakamoto, Shuichi, Tsukamoto, Shin-ichi

“…A novel series of benzazepine derivatives was prepared, and their binding affinities for 5-HT 2C, 5-HT 2A, and 5-HT 2B receptors were evaluated. Synthesis and…”
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Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol -1 -yl)ethylamine derivatives as 5-HT2Creceptor agonists by SHIMADA, Itsuro, MAENO, Kyoichi, TSUKAMOTO, Shin-Ichi, KAZUTA, Ken-Ichi, KUBOTA, Hideki, KIMIZUKA, Tetsuya, KIMURA, Yasuharu, HATANAKA, Ken-Ichi, NAITOU, Yuki, WANIBUCHI, Fumikazu, SAKAMOTO, Shuichi

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Synthesis and structure–activity relationships of a series of substituted 2-(1 H-furo[2,3- g]indazol-1-yl)ethylamine derivatives as 5-HT 2C receptor agonists by Shimada, Itsuro, Maeno, Kyoichi, Kazuta, Ken-ichi, Kubota, Hideki, Kimizuka, Tetsuya, Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Wanibuchi, Fumikazu, Sakamoto, Shuichi, Tsukamoto, Shin-ichi

“…A novel series of indazole derivatives were prepared, and their binding affinities for 5-HT 2C and 5-HT 2A receptors were evaluated. Synthesis and…”
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Corrigendum to “Pharmacological profile of YM348, a novel, potent and orally active 5-HT2c receptor agonist” [Eur. J. Pharmacol. 483 (2004) 37–43] by Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Maeno, Kyoichi, Shimada, Itsuro, Koakutsu, Akiko, Wanibuchi, Fumikazu, Yamaguchi, Tokio

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Corrigendum to “Pharmacological profile of YM348, a novel, potent and orally active 5-HT 2c receptor agonist” [Eur. J. Pharmacol. 483 (2004) 37–43] by Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Maeno, Kyoichi, Shimada, Itsuro, Koakutsu, Akiko, Wanibuchi, Fumikazu, Yamaguchi, Tokio

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Effects of dopamine agonistic and anticholinergic agents on catalepsy induced by D-1, D-2, and D-1/D-2 dopamine antagonists in rats by Wanibuchi, Fumikazu, Hagiwara-Oda, Keiko, Usuda, Shinji

“…Catalepsy induced by many neuroleptics is connected with an increase in the striatal cholinergic neuron activity subsequant to reduction of the nigrostriatal…”
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Reduction of cataleptic response by high doses of YM-09151-2, an antidopaminergic benzamide by Usuda, Shinji, Oda, Keiko, Wanibuchi, Fumikazu

“…Extrapyramidal side effects (EPS) of some antipsychotics are known to be reduced when they are given in high doses. The ability of antipsychotics to induce EPS…”
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The effect of suramin on mechanical allodynia developing in melanoma-implanted mice by Yukinori Nagakura, Tomonari Watabiki, Seiji Tamura, Shuicbirou Kakimoto, Yukihiro Takemoto, Fumikazu Wanibuchi, Masamichi Okada, Tokio Yamaguchi

“…Suramin has been extensively evaluated as an anti-cancer agent. Interestingly, it has been shown that it exerts an analgesic effect in hormone-refractory…”
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Phencyclidine-induced abnormal behaviors in rats as measured by the hole board apparatus by MORITA, T, SONODA, R, NAKATO, K, KOSHIYA, K, WANIBUCHI, F, YAMAGUCHI, T

“…Phencyclidine (PCP) and methamphetamine (MAP) are known as psychotomimetic agents. Both agents produce behavioral alterations in animals. The present study…”
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Synergistic effects between D-1 and D-2 dopamine antagonists on catalepsy in rats by Wanibuchi, F, Usuda, S

“…The effect of selective D-1 and D-2 dopamine agonists on catalepsy induced by various dopamine antagonists was studied. A potent and selective D-2 antagonist,…”
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Synthesis and Pharmacological Characterization of Novel 6-Fluorochroman Derivatives as Potential 5-HT1A Receptor Antagonists by Yasunaga, Tomoyuki, Kimura, Takenori, Naito, Ryo, Kontani, Toru, Wanibuchi, Fumikazu, Yamashita, Hiroshi, Nomura, Tamako, Tsukamoto, Shin-ichi, Yamaguchi, Tokio, Mase, Toshiyasu

“…A series of novel 6-fluorochroman derivatives was prepared and evaluated as antagonists for the 5-HT1A receptor…”
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Characterization of a novel muscarinic receptor agonist, YM796: comparison with cholinesterase inhibitors in in vivo pharmacological studies by Wanibuchi, F, Nishida, T, Yamashita, H, Hidaka, K, Koshiya, K, Tsukamoto, S, Usuda, S

“…Previous reports have shown that (+/-)-YM796 (2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane) exhibits M1 agonistic activity and ameliorates cognitive…”
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