Search Results - "Wani, M. C."

Camptothecin and taxol: from discovery to clinic by Wall, Monroe E., Wani, Mansukh C.

“…Camptothecin (CPT) and taxol are secondary metabolites found in the stembark of Camptotheca acuminata, a native of China, and Taxus brevifolia, found in the…”
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Novel strategies for the discovery of plant-derived anticancer agents by Kinghorn, A. D., Farnsworth, Norman R., Soejarto, D. D., Cordell, G. A., Pezzuto, J. M., Udeani, G. O., Wani, M. C., Wall, M. E., Navarro, H. A., Kramer, R. A., Menendez, A. T., Fairchild, Craig R., Lane, K. E., Forenza, Salvatore, Vyas, D. M., Lam, K. S., Shu, Y.-Z.

“…Abstract…”
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Interaction of an Alkylating Camptothecin Derivative with a DNA Base at Topoisomerase I-DNA Cleavage Sites by Pommier, Yves, Kohlhagen, Glenda, Kohn, Kurt W., Leteurtre, Francois, Wani, Mansukh C., Wall, Monroe E.

“…DNA topoisomerase I (top1) is a ubiquitous nuclear enzyme. It is specifically inhibited by camptothecin, a natural product derived from the bark of the tree…”
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Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum by SEO, Eun-Kyoung, KIM, Nam-Cheol, MI, Qiuwen, CHAI, Heebyung, WALL, Monroe E., WANI, Mansukh C., NAVARRO, Hernán A., BURGESS, Jason P., GRAHAM, James G., CABIESES, Fernando, TAN, Ghee T., FARNSWORTH, Norman R., PEZZUTO, John M., KINGHORN, A. Douglas

“…A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium…”
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Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase. I: Evidence for a specific receptor site and a relation to antitumor activity by JAXEL, C, KOHN, K. W, WANI, M. C, WALL, M. E, POMMIER, Y

“…Twenty-two compounds related to camptothecin, a known inhibitor of eukaryotic topoisomerase I, were studied. The following effects on the actions of…”
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DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts by Giovanella, Beppino C., Stehlin, John S., Wall, Monroe E., Wani, Mansukh C., Nicholas, Allan W., Liu, Leroy F., Silber, Robert, Potmesil, Milan

“…Drug development is needed to improve chemotherapy of patients with locally advanced or metastatic colon carcinoma, who otherwise have an unfavorable…”
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Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells by DEL POETA, M, CHEN, S.-F, VON HOFF, D, DYKSTRA, C. C, WANI, M. C, MANIKUMAR, G, HEITMAN, J, WALL, M. E, PERFECT, J. R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Lipid bilayer partitioning and stability of camptothecin drugs by Burke, Thomas G, Mishra, Awadesh K, Wani, Mansukh C, Wall, Monroe E

“…The intense intrinsic fluorescence emissions from several clinically relevant camptothecin drugs have been exploited in order to determine (1) the structural…”
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Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal by Wall, M.E., Wani, M.C., Brown, D.M., Fullas, F., Olwald, J.B., Josephson, F.F., Thornton, N.M., Pezzuto, J.M., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D.

“…Ethyl acetate and aqueous extracts of tannin-containing topoisomerase inhibitory plant samples were subjected to one or more of seven tannin removal…”
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Camptothecin and taxol : discovery to clinic : thirteenth Bruce F. Cain memorial Award lecture by WALL, M. E, WANI, M. C

“…Camptothecin and taxol are secondary metabolites found, respectively, in the wood bark of Camptotheca acuminata, a native of China, and Taxus brevifolia, found…”
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Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells by CHEN, A. Y, CHIANG YU, POTMESIL, M, WALL, M. E, WANI, M. C, LIU, L. F

“…In order to understand the high efficacy of camptothecin derivatives against human colon tumor xenografts in nude mice, we have studied the transport…”
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Cytotoxic constituents from the roots of Tovomita brevistaminea by Seo, Eun-Kyoung, Wall, Monroe E., Wani, Mansukh C., Navarro, Hernan, Mukherjee, Rabindranath, Farnsworth, Norman R., Kinghorn, A.Douglas

“…Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl 3 extract of the roots of Tovomita…”
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Isolation of Symlandine from the Roots of Common Comfrey (Symphytum officinale) Using Countercurrent Chromatography by Kim, Nam-Cheol, Oberlies, Nicholas H, Brine, Dolores R, Handy, Robert W, Wani, Mansukh C, Wall, Monroe E

“…Three pyrrolizidine alkaloids, symlandine, symphytine, and echimidine (1−3), were isolated from the roots of Symphytum officinale using a one-step…”
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New biphenyl compounds with DNA strand-scission activity from Clusia paralicola by Seo, E.K, Huang, L, Wall, M.E, Wani, M.C, Navarro, H, Mukherjee, R, Farnsworth, N.R, Konghorn, A.D

“…Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed…”
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Antitrypanosomal activity of camptothecin analogs: Structure-activity correlations by Bodley, Annette L., Wani, Mansukh C., Wall, Monroe E., Shapiro, Theresa A.

“…African trypanosomes ( Trypanosoma brucei species) are parasitic protozoa that cause lethal diseases in humans and cattle. Previous studies showed that…”
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Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts by WADKINS, R. M, POTTER, P. M, VLADU, B, MARTY, J, MANGOLD, G, WEITMAN, S, MANIKUMAR, G, WANI, M. C, WALL, M. E, VON HOFF, D. D

“…Water-soluble 20(S)-glycinate esters of two highly potent 10,11-methylenedioxy analogues of camptothecin (CPT) have been synthesized and evaluated for their…”
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New Compounds with DNA Strand-Scission Activity from the Combined Leaf and Stem of Uvaria hamiltonii by Huang, Li, Wall, Monroe E, Wani, Mansukh C, Navarro, Hernán, Santisuk, Thawatchai, Reutrakul, Vichai, Seo, Eun-Kyoung, Farnsworth, Norman R, Kinghorn, A. Douglas

“…Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated…”
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16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity by Wagner, B L, Pollio, G, Leonhardt, S, Wani, M C, Lee, D Y, Imhof, M O, Edwards, D P, Cook, C E, McDonnell, D P

“…Previously, we have shown that agonists and antagonists interact with distinct, though overlapping regions within the human progesterone receptor (hPR)…”
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Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11 beta-aryl steroids by Cook, C E, Lee, Y W, Wani, M C, Fail, P A, Petrow, V

“…The discovery of antiprogestational steroids by the Roussel-Uclaf group not only was a major scientific advance but also opened the way to new methods of…”
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Pentacyclic Triterpenes Derived from Maprounea africana Are Potent Inhibitors of HIV-1 Reverse Transcriptase by Pengsuparp, Thitima, Cai, Lining, Fong, Harry H. S, Kinghorn, A. Douglas, Pezzuto, John M, Wani, Mansukh C, Wall, Monroe E

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