Search Results - "Wange, L."

Considerations regarding the use of nonhuman primates in assessing safety endpoints for pharmaceuticals by Brown, Paul C., Wange, Ronald L.

“…Nonhuman primates (NHP) have become a commonly used nonrodent species for general toxicity testing for pharmaceuticals reviewed by CDER. Their increased use in…”
Get full text

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration by Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei

“…Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current…”
Get full text

FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations by Ackley, David, Birkebak, Joanne, Blumel, Jorg, Bourcier, Todd, de Zafra, Christina, Goodwin, Andrew, Halpern, Wendy, Herzyk, Danuta, Kronenberg, Sven, Mauthe, Robert, Shenton, Jacintha, Shuey, Dana, Wange, Ronald L.

“…The nonhuman primate (NHP) has always been a limited resource for pharmaceutical research with ongoing efforts to conserve. This is due to their inherent…”
Get full text

Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML by Nixdorf, D., Sponheimer, M., Berghammer, D., Engert, F., Bader, U., Philipp, N., Kazerani, M., Straub, T., Rohrbacher, L., Wange, L., Dapa, S., Atar, D., Seitz, C. M., Brandstetter, K., Linder, A., von Bergwelt, M., Leonhardt, H., Mittelstaet, J., Kaiser, A., Bücklein, V., Subklewe, M.

“…Although the landscape for treating acute myeloid leukemia (AML) patients has changed substantially in recent years, the majority of patients will eventually…”
Get full text

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation by Shan, Xiaochuan, Czar, Michael J., Bunnell, Stephen C., Liu, Pinghu, Liu, Yusen, Schwartzberg, Pamela L., Wange, Ronald L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Complex Complexes: Signaling at the TCR by Wange, Ronald L, Samelson, Lawrence E

“…Engagement of the T cell antigen receptor (TCR) on mature peripheral T cells initiates multiple intracellular signals that can lead to cellular proliferation…”
Get full text

S105: IN VIVO PDX CRISPR/CAS9 SCREENS REVEAL MUTUAL THERAPEUTIC TARGETS TO OVERCOME HETEROGENEOUS ACQUIRED CHEMO‐RESISTANCE by Wirth, A.‐K., Wange, L., Vosberg, S., Jayavelu, A. K., Enard, W, Herold, T, Jeremias, I

Get full text

T cell receptor signaling: beyond complex complexes by Huang, Yanping, Wange, Ronald L

Get full text

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists by Madrenas, Joaquín, Wange, Ronald L., Wang, Jennifer L., Isakov, Noah, Samelson, Lawrence E., Germain, Ronald N.

“…Small changes in the peptide-major histocompatibility complex (MHC) molecule ligands recognized by antigen-specific T cell receptors (TCRs) can convert fully…”
Get full text

Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells by Huang, Yanping, Norton, Darrell D., Precht, Patricia, Martindale, Jennifer L., Burkhardt, Janis K., Wange, Ronald L.

“…ADAP (adhesion and degranulation-promoting adaptor protein) and SKAP55 (Src kinase-associated phosphoprotein of 55 kDa) are T cell adaptors that mediate…”
Get full text

Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line by Williams, Brandi L., Schreiber, Kathy L., Zhang, Weiguo, Wange, Ronald L., Samelson, Lawrence E., Leibson, Paul J., Abraham, Robert T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Implementation of the principles of the 3Rs of animal testing at CDER: Past, present and future by Wange, Ronald L., Brown, Paul C., Davis-Bruno, Karen L.

“…The safety testing of pharmaceutical candidates has traditionally relied on data gathered from studies in animals, and these sources of information remain a…”
Get full text

Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment by Shan, Xiaochuan, Wange, Ronald L.

“…The Tec family tyrosine kinase, Itk has been implicated in T cell antigen receptor (TCR) signaling, yet little is known about Itk regulation. Here, we…”
Get full text

Exploring rabbit as a nonrodent species for general toxicology studies by Sokolowski, Katie, Turner, Patricia V, Lewis, Elise, Wange, Ronald L, Fortin, Marie C

“…Abstract To avoid adverse events in humans, toxicity studies in nonclinical species have been the foundation of safety evaluation in the pharmaceutical…”
Get full text

An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs) by Avila, Amy M., Bebenek, Ilona, Bonzo, Jessica A., Bourcier, Todd, Davis Bruno, Karen L., Carlson, David B., Dubinion, John, Elayan, Ikram, Harrouk, Wafa, Lee, Shwu-Luan, Mendrick, Donna L., Merrill, Jill C., Peretz, Jackye, Place, Emily, Saulnier, Muriel, Wange, Ronald L., Yao, Jia, Zhao, Dong, Brown, Paul C.

“…Nonclinical testing of human pharmaceuticals is conducted to assess the safety of compounds to be studied in human clinical trials and for marketing of new…”
Get full text

Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton by Dombroski, Derek, Houghtling, Richard A, Labno, Christine M, Precht, Patricia, Takesono, Aya, Caplen, Natasha J, Billadeau, Daniel D, Wange, Ronald L, Burkhardt, Janis K, Schwartzberg, Pamela L

“…The Tec family kinase Itk is an important regulator of Ca(2+) mobilization and is required for in vivo responses to Th2-inducing agents. Recent data also…”
Get full text

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor by Donovan, J A, Wange, R L, Langdon, W Y, Samelson, L E

“…Tyrosine phosphorylation of multiple cellular proteins is a critical event in T cell receptor (TCR)-mediated activation. This pathway has also been implicated…”
Get full text

Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial by Seminario, Maria-Cristina, Wange, Ronald L.

“…The initiating events associated with T activation in response to stimulation of the T cell antigen receptor (TCR) and costimulatory receptors, such as CD28,…”
Get full text

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70 by Watts, J D, Affolter, M, Krebs, D L, Wange, R L, Samelson, L E, Aebersold, R

“…We have developed a rapid and sensitive two capillary-column chromatography and mass spectrometry-based method for the determination of protein phosphorylation…”
Get full text

PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression by SEMINARIO, Maria-Cristina, PRECHT, Patricia, WERSTO, Robert P, GOROSPE, Myriam, WANGE, Ronald L

“…The balance of activities between the proto-oncogene phosphoinositide 3-kinase (PI3K) and the tumour suppressor gene PTEN has been shown to affect cellular…”
Get full text