Search Results - "Wang, Yong Xiang"

Protopanaxadiol alleviates neuropathic pain by spinal microglial dynorphin A expression following glucocorticoid receptor activation by Shoaib, Rana Muhammad, Ahmad, Khalil Ali, Wang, Yong‐Xiang

“…Background and Purpose New remedies are required for the treatment of neuropathic pain due to insufficient efficacy of available therapies. This study provides…”
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Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels by Huang, Qian, Chen, Yuan, Gong, Nian, Wang, Yong-Xiang

“…Abstract Objective Methylglyoxal is known to be associated with the development of nephropathy, retinopathy, and other complications in diabetes. The present…”
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Spinal microglial β‐endorphin signaling mediates IL‐10 and exenatide‐induced inhibition of synaptic plasticity in neuropathic pain by Ma, Le, Peng, Shiyu, Wei, Jinbao, Zhao, Mengjing, Ahmad, Khalil Ali, Chen, Jinghong, Wang, Yong‐Xiang

“…Aim This study aimed to investigate the regulation of pain hypersensitivity induced by the spinal synaptic transmission mechanisms underlying interleukin…”
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The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors by Apryani, Evhy, Ali, Usman, Wang, Zi-Ying, Wu, Hai-Yun, Mao, Xiao-Fang, Ahmad, Khalil Ali, Li, Xin-Yan, Wang, Yong-Xiang

“…Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain…”
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Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway by Ali, Usman, Apryani, Evhy, Wu, Hai-Yun, Mao, Xiao-Fang, Liu, Hao, Wang, Yong-Xiang

“…[Display omitted] •Electroacupuncture (EA) alleviates neuropathic pain.•EA stimulates spinal microglial expression of IL-10 and subsequent β-endorphin.•EA…”
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Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway by Mao, Xiao-Fang, Wu, Hai-Yun, Tang, Xue-Qi, Ali, Usman, Liu, Hao, Wang, Yong-Xiang

“…The G protein-coupled receptor 40 (GPR40), broadly expressed in various tissues such as the spinal cord, exerts multiple physiological functions including pain…”
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Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity by Gong, Nian, Xiao, Qi, Zhu, Bin, Zhang, Chang-Yue, Wang, Yan-Chao, Fan, Hui, Ma, Ai-Niu, Wang, Yong-Xiang

“…This study aims to identify the inhibitory role of the spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism of…”
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Hydrophilic Quaternary Ammonium-Group-Containing [FeFe]-Hydrogenase Models: Synthesis, Structures, and Electrocatalytic Hydrogen Production by Song, Li-Cheng, Wang, Yong-Xiang, Xing, Xu-Kang, Ding, Shu-Da, Zhang, Long-Duo, Wang, Xu-Yong, Zhang, Hong-Tao

“…The first quaternary ammonium‐group‐containing [FeFe]‐hydrogenase models [(μ‐PDT)Fe2(CO)4{κ2‐(Ph2P)2N(CH2)2NMe2BzBr}] (2; PDT=propanedithiolate) and…”
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Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion by Wang, Yang, Li, Qiqi, Li, Cheng, Wang, Cong, Wang, Shijie, Yuan, Wenjie, Yu, Demin, Zhang, Ke, Shi, Bisheng, Chen, Xiaomei, Liu, Tiantian, Yuan, Zhenghong, Tong, Shuping, Nassal, Michael, Wen, Yu-Mei, Wang, Yong-Xiang

“…Chronic hepatitis B (CHB) caused by HBV infection greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. Hepatitis B surface antigen…”
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Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon‐like peptide‐1 receptors by Xu, Meng, Wu, Hai‐Yun, Liu, Hao, Gong, Nian, Wang, Yi‐Rui, Wang, Yong‐Xiang

“…Background and Purpose Iridoid glycosides containing the double bond scaffold of cyclopentapyran are reversible and orthosteric agonists of glucagon‐like…”
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Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors by Gong, Nian, Fan, Hui, Ma, Ai-Niu, Xiao, Qi, Wang, Yong-Xiang

“…We recently discovered that the activation of the spinal glucagon-like peptide-1 receptors (GLP-1Rs) by the peptidic agonist exenatide produced antinociception…”
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A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments by Wang, Yang, Yuan, Wenjie, Guo, Siqi, Li, Qiqi, Chen, Xiaomei, Li, Cheng, Liu, Qianying, Sun, Lei, Chen, Zhenguo, Yuan, Zhenghong, Luo, Cheng, Chen, Shijie, Tong, Shuping, Nassal, Michael, Wen, Yu-Mei, Wang, Yong-Xiang

“…Single-chain variable fragments (scFvs), composed of variable domains of heavy and light chains of an antibody joined by a linker, share antigen binding…”
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Lappaconitine, a C18-diterpenoid alkaloid, exhibits antihypersensitivity in chronic pain through stimulation of spinal dynorphin A expression by Sun, Ming-Li, Ao, Jun-Ping, Wang, Yi-Rui, Huang, Qian, Li, Teng-Fei, Li, Xin-Yan, Wang, Yong-Xiang

“…Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in…”
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The y271 and i274 amino acids in reverse transcriptase of human immunodeficiency virus-1 are critical to protein stability by Zhang, Hao-Jie, Wang, Yong-Xiang, Wu, Hao, Jin, Dong-Yan, Wen, Yu-Mei, Zheng, Bo-Jian

“…Reverse transcriptase (RT) of human immunodeficiency virus (HIV)-1 plays a key role in initiating viral replication and is an important target for developing…”
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Acupuncture/Electroacupuncture as an Alternative in Current Opioid Crisis by Ali, Usman, Apryani, Evhy, Ahsan, Muhammad Zaeem, Shoaib, Rana Muhammad, Ahmad, Khalil Ali, Wang, Yong-xiang

“…Opioid drugs are the first line of defense in severe pain but the adverse effects associated with opioids are considered as a serious issue worldwide…”
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Ginsenoside Rb1, a principal effective ingredient of Panax notoginseng, produces pain antihypersensitivity by spinal microglial dynorphin A expression by Shoaib, Rana Muhammad, Ahsan, Muhammad Zaeem, Akhtar, Usman, Ahmad, Khalil Ali, Ali, Usman, Deng, Men-Yan, Li, Xin-Yan, Wang, Yong-Xiang

“…Panax notoginseng (Chinese ginseng, Sanqi), one of the major ginseng species, has been traditionally used to alleviate different types of chronic pain. The raw…”
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d‐Amino acid oxidase‐mediated increase in spinal hydrogen peroxide is mainly responsible for formalin‐induced tonic pain by Lu, Jin‐Miao, Gong, Nian, Wang, Yan‐Chao, Wang, Yong‐Xiang

“…BACKGROUND AND PURPOSE Spinal reactive oxygen species (ROS) are critically involved in chronic pain. d‐Amino acid oxidase (DAAO) oxidizes d‐amino acids such as…”
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Involvement of d‐amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice by Liu, Hao, Zhao, Meng‐Jing, Wang, Zi‐Ying, Han, Qiao‐Qiao, Wu, Hai‐Yun, Mao, Xiao‐fang, Wang, Yong‐Xiang

“…Background and Purpose d‐Amino acid oxidase (DAAO) is a flavine adenine dinucleotide‐containing flavoenzyme and specifically catalyses oxidative deamination of…”
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Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain by Li, Teng-Fei, Fan, Hui, Wang, Yong-Xiang

“…Ropivacaine is a local anesthetic widely used for regional anesthesia and epidural analgesia, but its relatively short duration limits its clinical use. A…”
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The non‐peptide GLP‐1 receptor agonist WB4‐24 blocks inflammatory nociception by stimulating β‐endorphin release from spinal microglia by Fan, Hui, Gong, Nian, Li, Teng‐Fei, Ma, Ai‐Niu, Wu, Xiao‐Yan, Wang, Ming‐Wei, Wang, Yong‐Xiang

“…Background and Purpose Two peptide agonists of the glucagon‐like peptide‐1 (GLP‐1) receptor, exenatide and GLP‐1 itself, exert anti‐hypersensitive effects in…”
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