Search Results - "Wang, Yingyun"

A Multi Object Tracking Framework Based on YOLOv8s and Bytetrack Algorithm by Wang, Yingyun, Mariano, Vladimir Y.

“…In recent years, the YOLOv8 series algorithms have become a research hotspot in many fields, and they can perform excellently in different computer vision…”
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Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation by Lu, Jing, Zavorotinskaya, Tatiana, Dai, Yumin, Niu, Xiao-Hong, Castillo, Joseph, Sim, Janet, Yu, Jianjun, Wang, Yingyun, Langowski, John L., Holash, Jocelyn, Shannon, Kevin, Garcia, Pablo D.

“…Multiple myeloma (MM) is the second most common hematologic malignancy. Despite recent treatment advances, it remains incurable. Here, we report that Pim2…”
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Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers by GARCIA, Pablo D, LANGOWSKI, John L, NIU, Xiao-Hong, BASHAM, Stephen, CHAN, Julie, JIANJUN YU, DOYLE, Michael, FEUCHT, Paul, WARNE, Robert, NARBERES, Jamie, TSANG, Tiffany, FRITSCH, Christine, YINGYUN WANG, KAUFFMANN, Audrey, PFISTER, Estelle, DRUECKES, Peter, TRAPPE, Joerg, WILSON, Christopher, WOOSEOK HAN, JIONG LAN, NISHIGUCHI, Gisele, LINDVALL, Mika, BELLAMACINA, Cornelia, MIN CHEN, AYCINENA, J. Alex, ZANG, Richard, HOLASH, Jocelyn, BURGER, Matthew T, CASTILLO, Joseph, FANTON, Christie, ISON, Marjorie, ZAVOROTINSKAYA, Tatiana, YUMIN DAI, JING LU

“…PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this,…”
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Identification of N‑(4-((1R,3S,5S)‑3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies by Burger, Matthew T, Nishiguchi, Gisele, Han, Wooseok, Lan, Jiong, Simmons, Robert, Atallah, Gordana, Ding, Yu, Tamez, Victoriano, Zhang, Yanchen, Mathur, Michelle, Muller, Kristine, Bellamacina, Cornelia, Lindvall, Mika K, Zang, Richard, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Basham, Steve, Chan, Julie, Ginn, Elaine, Aycinena, Alex, Holash, Jocelyn, Castillo, Joseph, Langowski, John L, Wang, Yingyun, Chen, Min Y, Lambert, Amy, Fritsch, Christine, Kauffmann, Audry, Pfister, Estelle, Vanasse, K. Gary, Garcia, Pablo D

“…Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM…”
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Effect of GS-441524 in combination with the 3C-like protease inhibitor GC376 on the treatment of naturally transmitted feline infectious peritonitis by Lv, Jinbao, Bai, Yang, Wang, Yingyun, Yang, Liu, Jin, Yipeng, Dong, Jun

“…Objectives The main objectives of this study were to investigate the efficacy of the nucleotide analog GS-441524 in combination with the 3C-like protease…”
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF by Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

“…Resistance to the RAF inhibitor vemurafenib arises commonly in melanomas driven by the activated BRAF oncogene. Here, we report antitumor properties of RAF709,…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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The first outbreak of feline panleukopenia virus infection in captive Pallas's cats in Xining Wildlife Park by Wei, Jingjie, Shi, Yuqi, Wang, Xiaofei, He, Shunfu, Qi, Xinzhang, Lu, Rong, Gao, Yuhang, Liu, ZiChen, Wang, Yingyun, Wu, Yuanheng, Jin, Yipeng

“…In August 2021, an outbreak of Feline Panleukopenia Virus (FPV) was observed in four 3-month-old Pallas' cats at Xining Wildlife Park. Despite timely…”
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A comparative study of skin transcriptomes and histological observations for black and white hair colors of giant panda by Wang, Yingyun, Liang, Shangyue, Tu, Shaotong, Shen, Zhangqi, Dong, Yanjun, Liu, Gang, Shi, Hao, Jin, Yipeng

“…The Giant pandas ( ) are mammals belonging to the bear family, order Carnivora, and their characteristic hair color and distribution has been in the spotlight…”
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Special architecture and anti-wear strategies for giant panda tooth enamel: Based on wear simulation findings by Wu, Yuanheng, Liu, Jinxing, Yang, Yongqiang, Tu, Shaotong, Liu, Zichen, Wang, Yingyun, Peng, Chen, Liu, Gang, Jin, Yipeng

“…Giant pandas are the flagship species in world conservation. Due to bamboo being the primary food source for giant pandas, dental wear is common owing to the…”
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Galectin-1: A Link Between Tumor Hypoxia and Tumor Immune Privilege by Le, Quynh-Thu, Shi, Gongyi, Cao, Hongbin, Nelson, Daniel W, Wang, Yingyun, Chen, Eunice Y, Zhao, Shuchun, Kong, Christina, Richardson, Donna, O'Byrne, Ken J, Giaccia, Amato J, Koong, Albert C

“…To identify a 15-KDa novel hypoxia-induced secreted protein in head and neck squamous cell carcinomas (HNSCC) and to determine its role in malignant…”
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Design and molecular insights of drug-active metabolite based co-amorphous formulation: A case study of toltrazuril-ponazuril co-amorphous by Li, Bin, Wang, Yingyun, Feng, Ying, Yuan, Dan, Xu, Renjie, Jiang, Cuiping, Xiao, Xuecheng, Lu, Shan

“…[Display omitted] •Drug’s active metabolite was a potential co-former for drug-drug co-amorphous system.•Drug-drug combination with similar chemical structures…”
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Lattice distortion dependent photoluminescence in two-dimensional hybrid manganese halides by regulating penetration depth of organic amine by Wang, Yingyun, Zhang, Shuai, Hou, Haowen, Yin, Yuehong, Zou, Bingsuo, Zeng, Ruosheng

“…Organic−inorganic hybrid Mn-based metal halides display diverse rich optical properties due to their diverse crystal structures and have become one of the most…”
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Enhanced fault localization in multi-terminal transmission lines using novel machine learning by Wang Yingyun, Qi Xiaoxia, Chen Yang

“…Accurate fault location on transmission lines is paramount for ensuring the reliable and efficient operation of the electricity grid, which underpins every…”
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Complexation of Apigenin and Oxymatrine Leading to Enhanced Anti-inflammatory Activity by Yuan, Dan, Wang, Ziling, Li, Bin, Li, Xiaoxuan, Wang, Yingyun, Wang, Xinyu, Cao, Jin, Guo, Yujie, Du, Hongzhi, Lu, Shan

“…Apigenin (APG) is a well-known dietary flavonoid with multiple bioactivities, but its poor aqueous solubility may result in low oral bioavailability and thus…”
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Targeted ablation of FoxP3+ T cells activates peripheral and tumor-infiltrating cytotoxic CD8+ T cells in multiple syngeneic mouse tumor models by Delfino, Teresita, Wang, Yingyun, Schartner, Jill, Rutz, Sascha

“…Abstract FoxP3+ regulatory T cells (Treg) are essential to prevent autoimmunity, but have also been implicated in suppressing anti-tumor immune responses. We…”
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Sishen Wan Treats Ulcerative Colitis in Rats by Regulating Gut Microbiota and Restoring the Treg/Th17 Balance by Wang, Yingyun, Zhu, Xiangdong, Liang, Yonglin, Li, Xinze, Wang, Yan, Li, Jie

“…Objective. This study was aimed to explore the mechanism of Sishen Wan (SSW) in treating ulcerative colitis (UC) in a rat model of spleen-kidney yang…”
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Foxp3+ regulatory T cells suppress T cell immunity in inflamed and non-inflamed tumors by distinct mechanisms by Delfino, Teresita, Wang, Yingyun, Muller, Soren, Iftikar, Hina, Modrusan, Zora, Schartner, Jill, Rutz, Sascha

“…Abstract Foxp3+ regulatory T cells (Treg) are essential to prevent autoimmunity, but may also suppress anti-tumor immune responses. The relevance of Treg…”
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy by Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika

“…RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations occurring at…”
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Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells by Gampa, Gautham, Spinosa, Phillip, Getz, Jennifer, Zhong, Yu, Halpern, Wendy, Esen, Emel, Davies, John, Chou, Cassie, Kwong, Mandy, Wang, Yingyun, Arenzana, Teresita L., Shivva, Vittal, Huseni, Mahrukh, Hsieh, Robert, Schartner, Jill, Koerber, James T., Rutz, Sascha, Hosseini, Iraj

“…Background and Purpose RO7502175 is an afucosylated antibody designed to eliminate C–C motif chemokine receptor 8 (CCR8)+ Treg cells in the tumour…”
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