Search Results - "Wang, Yifan E"
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Roles of Nucleoporin RanBP2/Nup358 in Acute Necrotizing Encephalopathy Type 1 (ANE1) and Viral Infection
Published in International journal of molecular sciences (24-03-2022)“…Ran Binding Protein 2 (RanBP2 or Nucleoporin358) is one of the main components of the cytoplasmic filaments of the nuclear pore complex. Mutations in the gene…”
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RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes
Published in PLoS genetics (01-02-2021)“…Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the…”
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RanBP2/Nup358 Mediates Sumoylation of STAT1 and Antagonizes Interferon-α-Mediated Antiviral Innate Immunity
Published in International journal of molecular sciences (25-12-2023)“…Type I interferon (IFN-I)-induced signaling plays a critical role in host antiviral innate immune responses. Despite this, the mechanisms that regulate this…”
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Rapid and inexpensive bedside diagnosis of RAN binding protein 2-associated acute necrotizing encephalopathy
Published in Frontiers in neurology (16-11-2023)“…Acute necrotizing encephalopathy 1 (ANE1) is a very rare disorder associated with a dominant heterozygous mutation in the (RAN binding protein 2) gene. ANE1 is…”
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Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection
Published in The Journal of biological chemistry (01-07-2021)“…The nuclear pore complex is the sole gateway connecting the nucleoplasm and cytoplasm. In humans, the nuclear pore complex is one of the largest multiprotein…”
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ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5' splice site motifs within nuclear speckles
Published in RNA (Cambridge) (01-06-2022)“…Quality control of mRNA represents an important regulatory mechanism for gene expression in eukaryotes. One component of this quality control is the nuclear…”
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