Search Results - "Wang, Yi Kan"

Diverse activation patterns during persistent atrial fibrillation by noncontact charge‐density mapping of human atrium by Shi, Rui, Chen, Zhong, Butcher, Charlie, Zaman, Junaid AB, Boyalla, Vennela, Wang, Yi Kan, Riad, Omar, Sathishkumar, Anitha, Norman, Mark, Haldar, Shouvik, Jones, David G, Hussain, Wajid, Markides, Vias, Wong, Tom

“…Background Global simultaneous recording of atrial activation during atrial fibrillation (AF) can elucidate underlying mechanisms contributing to AF…”
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Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer by Zhang, Allen W., McPherson, Andrew, Milne, Katy, Kroeger, David R., Hamilton, Phineas T., Miranda, Alex, Funnell, Tyler, Little, Nicole, de Souza, Camila P.E., Laan, Sonya, LeDoux, Stacey, Cochrane, Dawn R., Lim, Jamie L.P., Yang, Winnie, Roth, Andrew, Smith, Maia A., Ho, Julie, Tse, Kane, Zeng, Thomas, Shlafman, Inna, Mayo, Michael R., Moore, Richard, Failmezger, Henrik, Heindl, Andreas, Wang, Yi Kan, Bashashati, Ali, Grewal, Diljot S., Brown, Scott D., Lai, Daniel, Wan, Adrian N.C., Nielsen, Cydney B., Huebner, Curtis, Tessier-Cloutier, Basile, Anglesio, Michael S., Bouchard-Côté, Alexandre, Yuan, Yinyin, Wasserman, Wyeth W., Gilks, C. Blake, Karnezis, Anthony N., Aparicio, Samuel, McAlpine, Jessica N., Huntsman, David G., Holt, Robert A., Nelson, Brad H., Shah, Sohrab P.

“…High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We…”
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Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality by Anglesio, Michael S, Wang, Yi Kan, Maassen, Madlen, Horlings, Hugo M, Bashashati, Ali, Senz, Janine, Mackenzie, Robertson, Grewal, Diljot S, Li-Chang, Hector, Karnezis, Anthony N, Sheffield, Brandon S, McConechy, Melissa K, Kommoss, Friedrich, Taran, Florin A, Staebler, Annette, Shah, Sohrab P, Wallwiener, Diethelm, Brucker, Sara, Gilks, C Blake, Kommoss, Stefan, Huntsman, David G

“…Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian…”
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Clear cell carcinomas of the ovary and kidney: clarity through genomics by Ji, Jennifer X, Wang, Yi Kan, Cochrane, Dawn R, Huntsman, David G

“…Clear cell ovarian carcinoma (CCOC) and clear cell renal cell carcinoma (ccRCC) both feature clear cytoplasm, owing to the accumulation of cytoplasmic…”
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Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models by Funnell, Tyler, Zhang, Allen W, Grewal, Diljot, McKinney, Steven, Bashashati, Ali, Wang, Yi Kan, Shah, Sohrab P

“…Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic…”
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Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer by Duffy, Supipi, Fam, Hok Khim, Wang, Yi Kan, Styles, Erin B., Kim, Jung-Hyun, Ang, J. Sidney, Singh, Tejomayee, Larionov, Vladimir, Shah, Sohrab P., Andrews, Brenda, Boerkoel, Cornelius F., Hieter, Philip

“…Somatic copy number amplification and gene overexpression are common features of many cancers. To determine the role of gene overexpression on chromosome…”
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Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease by Pilsworth, Jessica A, Cochrane, Dawn R, Neilson, Samantha J, Moussavi, Bahar H, Lai, Daniel, Munzur, Aslı D, Senz, Janine, Wang, Yi Kan, Zareian, Sina, Bashashati, Ali, Wong, Adele, Keul, Jacqueline, Staebler, Annette, Meurs, Hannah S, Horlings, Hugo M, Kommoss, Stefan, Kommoss, Friedrich, Oliva, Esther, Färkkilä, Anniina EM, Gilks, Blake, Huntsman, David G

“…Adult‐type granulosa cell tumors (aGCTs) account for 90% of malignant ovarian sex cord‐stromal tumors and 2–5% of all ovarian cancers. These tumors are usually…”
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Correction: TERT promoter mutation in adult granulosa cell tumor of the ovary by Pilsworth, Jessica A., Cochrane, Dawn R., Xia, Zhouchunyang, Aubert, Geraldine, Färkkilä, Anniina E. M., Horlings, Hugo M., Yanagida, Satoshi, Yang, Winnie, Lim, Jamie L. P., Wang, Yi Kan, Bashashati, Ali, Keul, Jacqueline, Wong, Adele, Norris, Kevin, Brucker, Sara Y., Taran, Florin-Andrei, Krämer, Bernhard, Staebler, Annette, van Meurs, Hannah, Oliva, Esther, Shah, Sohrab P., Kommoss, Stefan, Kommoss, Friedrich, Gilks, C. Blake, Baird, Duncan M., Huntsman, David G.

“…The original version of this Article omitted the author Hannah van Meurs from the Department of Gynecology, Center for Gynecologic Oncology Amsterdam, Academic…”
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NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks by Hurley, Daniel G, Cursons, Joseph, Kan Wang, Yi, Budden, David M, Print, Cristin G, Crampin, Edmund J

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Integration of steady-state and temporal gene expression data for the inference of gene regulatory networks by Wang, Yi Kan, Hurley, Daniel G, Schnell, Santiago, Print, Cristin G, Crampin, Edmund J

“…We develop a new regression algorithm, cMIKANA, for inference of gene regulatory networks from combinations of steady-state and time-series gene expression…”
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Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes by Wang, Yi Kan, Bashashati, Ali, Anglesio, Michael S, Cochrane, Dawn R, Grewal, Diljot S, Ha, Gavin, McPherson, Andrew, Horlings, Hugo M, Senz, Janine, Prentice, Leah M, Karnezis, Anthony N, Lai, Daniel, Aniba, Mohamed R, Zhang, Allen W, Shumansky, Karey, Siu, Celia, Wan, Adrian, McConechy, Melissa K, Li-Chang, Hector, Tone, Alicia, Provencher, Diane, de Ladurantaye, Manon, Fleury, Hubert, Okamoto, Aikou, Yanagida, Satoshi, Yanaihara, Nozomu, Saito, Misato, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Gilks, C Blake, Mes-Masson, Anne-Marie, McAlpine, Jessica N, Aparicio, Samuel, Huntsman, David G, Shah, Sohrab P

“…Sohrab Shah, David Huntsman and colleagues report the genomic analysis of 133 ovarian cancers spanning different subtypes. They identify seven subgroups using…”
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Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden by Anglesio, Michael S, Bashashati, Ali, Wang, Yi Kan, Senz, Janine, Ha, Gavin, Yang, Winnie, Aniba, Mohamed R, Prentice, Leah M, Farahani, Hossein, Li Chang, Hector, Karnezis, Anthony N, Marra, Marco A, Yong, Paul J, Hirst, Martin, Gilks, Blake, Shah, Sohrab P, Huntsman, David G

“…Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole‐genome…”
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A foundation model for clinical-grade computational pathology and rare cancers detection by Vorontsov, Eugene, Bozkurt, Alican, Casson, Adam, Shaikovski, George, Zelechowski, Michal, Severson, Kristen, Zimmermann, Eric, Hall, James, Tenenholtz, Neil, Fusi, Nicolo, Yang, Ellen, Mathieu, Philippe, van Eck, Alexander, Lee, Donghun, Viret, Julian, Robert, Eric, Wang, Yi Kan, Kunz, Jeremy D., Lee, Matthew C. H., Bernhard, Jan H., Godrich, Ran A., Oakley, Gerard, Millar, Ewan, Hanna, Matthew, Wen, Hannah, Retamero, Juan A., Moye, William A., Yousfi, Razik, Kanan, Christopher, Klimstra, David S., Rothrock, Brandon, Liu, Siqi, Fuchs, Thomas J.

“…The analysis of histopathology images with artificial intelligence aims to enable clinical decision support systems and precision medicine. The success of such…”
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A Genomics-Driven Artificial Intelligence-Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms by Pareja, Fresia, Dopeso, Higinio, Wang, Yi Kan, Gazzo, Andrea M, Brown, David N, Banerjee, Monami, Selenica, Pier, Bernhard, Jan H, Derakhshan, Fatemeh, da Silva, Edaise M, Colon-Cartagena, Lorraine, Basili, Thais, Marra, Antonio, Sue, Jillian, Ye, Qiqi, Da Cruz Paula, Arnaud, Yeni Yildirim, Selma, Pei, Xin, Safonov, Anton, Green, Hunter, Gill, Kaitlyn Y, Zhu, Yingjie, Lee, Matthew C H, Godrich, Ran A, Casson, Adam, Weigelt, Britta, Riaz, Nadeem, Wen, Hannah Y, Brogi, Edi, Mandelker, Diana L, Hanna, Matthew G, Kunz, Jeremy D, Rothrock, Brandon, Chandarlapaty, Sarat, Kanan, Christopher, Oakley, Joe, Klimstra, David S, Fuchs, Thomas J, Reis-Filho, Jorge S

“…Artificial intelligence (AI) systems can improve cancer diagnosis, yet their development often relies on subjective histologic features as ground truth for…”
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Abstract PD11-01: An artificial intelligence-based predictor of CDH1 biallelic mutations and invasive lobular carcinoma by Reis-Filho, Jorge S, Pareja, Fresia, Derakhshan, Fatemeh, Brown, David N, Sue, Jillian, Selenica, Pier, Wang, Yi Kan, Paula, Arnaud Da Cruz, Banerjee, Monami, Ebrahimzadeh, Zahra, Isava, Manuel, Lee, Matthew, Godrich, Ran, Casson, Adam, Padron, Ruben, Shaikovski, George, van Eck, Alexander, Marra, Antonio, Dopeso, Higinio, Wen, Hannah Y, Brogi, Edi, Hanna, Matthew G, Kanan, Chris, Kunz, Jeremy D, Geyer, Felipe C, Leibowitz, Carla, Klimstra, David, Grady, Leo, Fuchs, Thomas J

“…Abstract Introduction: Invasive lobular carcinoma (ILC) is the most frequent special histologic subtype of breast cancer (BC). ILC is identifiable by…”
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TERT promoter mutation in adult granulosa cell tumor of the ovary by Pilsworth, Jessica A., Cochrane, Dawn R., Xia, Zhouchunyang, Aubert, Geraldine, Färkkilä, Anniina E.M., Horlings, Hugo M., Yanagida, Satoshi, Yang, Winnie, Lim, Jamie L.P., Wang, Yi Kan, Bashashati, Ali, Keul, Jacqueline, Wong, Adele, Norris, Kevin, Brucker, Sara Y., Taran, Florin-Andrei, Krämer, Bernhard, Staebler, Annette, van Meurs, Hannah, Oliva, Esther, Shah, Sohrab P., Kommoss, Stefan, Kommoss, Friedrich, Gilks, C. Blake, Baird, Duncan M., Huntsman, David G.

“…The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by…”
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LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers by Xia, Zhouchunyang, Cochrane, Dawn R., Anglesio, Michael S., Wang, Yi Kan, Nazeran, Tayyebeh, Tessier-Cloutier, Basile, McConechy, Melissa K., Senz, Janine, Lum, Amy, Bashashati, Ali, Shah, Sohrab P., Huntsman, David G.

“…Endometrioid (ENOC) and clear cell ovarian carcinoma (CCOC) share a common precursor lesion, endometriosis, hence the designation endometriosis associated…”
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Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence by Wang, Yi Kan, Print, Cristin G, Crampin, Edmund J

“…Many studies have revealed correlations between breast tumour phenotypes, variations in gene expression, and patient survival outcomes. The molecular…”
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Abstract DPOC-014: BEYOND CODING MUTATIONS: USING RETROTRANSPOSONS TO PREDICT OVARIAN CANCER DEVELOPMENT by Xia, Zhouchunyang, Cochrane, Dawn, Anglesio, Michael S, Nazeran, Tayyebeh M, Senz, Janine, Lum, Amy, Bashashati, Ali, Wang, Yi Kan, Shah, Sohrab P, Huntsman, David

“…Abstract PURPOSE: Women with endometriosis, a painful condition caused by displaced endometrial tissue, have a 3-fold increased risk of developing endometrioid…”
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Abstract GMM-047: GENOMIC CHARACTERIZATION OF ADULT-TYPE GRANULOSA CELL TUMORS: IMPLICATIONS FOR PATHOGENESIS AND TREATMENT OF RECURRENT DISEASE by Pilsworth, Jessica A., Cochrane, Dawn R., Neilson, Samantha, Färkkilä, Anniina E.M., Horlings, Hugo M., Yanagida, Satoshi, Senz, Janine, Wang, Yi Kan, Moussavi, Bahar, Lai, Daniel, Bashashati, Ali, Keul, Jacqueline, Wong, Adele, Meurs, Hannah van, Brucker, Sara Y., Taran, Florin-Andrei, Krämer, Bernhard, Staebler, Annette, Oliva, Esther, Shah, Sohrab P., Kommoss, Stefan, Kommoss, Friedrich, Gilks, C. Blake, Huntsman, David G.

“…Abstract BACKGROUND: Adult granulosa cell tumors (AGCT) represent 3-5% of all ovarian cancers. These tumors are characterized by their slow growth and usually…”
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