Search Results - "Wang, Yaolai"
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Extracting predictors for lung adenocarcinoma based on Granger causality test and stepwise character selection
Published in BMC bioinformatics (01-05-2019)“…Lung adenocarcinoma is the most common type of lung cancer, with high mortality worldwide. Its occurrence and development were thoroughly studied by…”
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Signaling Mechanism of Transcriptional Bursting: A Technical Resolution-Independent Study
Published in Biology (Basel, Switzerland) (01-10-2020)“…Gene transcription has been uncovered to occur in sporadic bursts. However, due to technical difficulties in differentiating individual transcription…”
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Resembling the bottleneck effect in p53 core network including the dephosphorylation of ATM by Wip1: A computational study
Published in Frontiers in physics (09-11-2022)“…As one of the key proteins, wild-type p53 can inhibit the tumor development and regulate the cell fate. Thus, the study on p53 and its related kinetics has…”
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Reconciling the concurrent fast and slow cycling of proteins on gene promoters
Published in Journal of the Royal Society interface (06-07-2014)“…During gene transcription, proteins appear to cycle on and off some gene promoters with both long (tens of minutes) and short periods (no more than several…”
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Gene Biomarkers Derived from Clinical Data of Hepatocellular Carcinoma
Published in Interdisciplinary sciences : computational life sciences (01-06-2020)“…Hepatocellular carcinoma (HCC) is a common cancer of high mortality, mainly due to the difficulty in diagnosis during its clinical stage. Here we aim to find…”
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Gene transcription in bursting: a unified mode for realizing accuracy and stochasticity
Published in Biological reviews of the Cambridge Philosophical Society (01-02-2019)“…ABSTRACT There is accumulating evidence that, from bacteria to mammalian cells, messenger RNAs (mRNAs) are produced in intermittent bursts – a much ‘noisier’…”
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Kinetics of transcription initiation directed by multiple cis-regulatory elements on the glnAp2 promoter
Published in Nucleic acids research (15-12-2016)“…Transcription initiation is orchestrated by dynamic molecular interactions, with kinetic steps difficult to detect. Utilizing a hybrid method, we aim to…”
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Dynamic Mechanism for the Transcription Apparatus Orchestrating Reliable Responses to Activators
Published in Scientific reports (25-05-2012)“…The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA…”
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Dynamic Mechanism for the Transcription when Responses to Activators
Published in Biophysical journal (29-01-2013)Get full text
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