Search Results - "Wang, Yanchang"

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  1. 1

    Light- and Temperature-Induced Expression of an R2R3-MYB Gene Regulates Anthocyanin Biosynthesis in Red-Fleshed Kiwifruit by Yu, Min, Man, Yuping, Wang, Yanchang

    “…The R2R3 MYB genes associated with the flavonoid/anthocyanidin pathway feature two repeats, and represent the most abundant classes of MYB genes in plants;…”
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  2. 2

    The role of SUMOylation in biomolecular condensate dynamics and protein localization by Gutierrez-Morton, Emily, Wang, Yanchang

    Published in Cell insight (01-12-2024)
    “…As a type of protein post-translational modification, SUMOylation is the process that attaches a small ubiquitin-like modifier (SUMO) to lysine residues of…”
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  3. 3

    signaling network that silences the spindle assembly checkpoint upon the establishment of chromosome bipolar attachment by Jin, Fengzhi, Wang, Yanchang

    “…Improper kinetochore attachments activate the spindle assembly checkpoint (SAC) to prevent anaphase onset, but it is poorly understood how this checkpoint is…”
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  4. 4

    The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins by Folger, Austin, Wang, Yanchang

    Published in Cells (Basel, Switzerland) (21-10-2021)
    “…Protein misfolding and aggregation are implicated in many neurodegenerative diseases. One of these diseases is Huntington's, which is caused by increased…”
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    The current view for the silencing of the spindle assembly checkpoint by Wang, Yanchang, Jin, Fengzhi, Higgins, Ryan, McKnight, Kelly

    Published in Cell cycle (Georgetown, Tex.) (01-06-2014)
    “…Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is…”
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    Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase by Bokros, Michael, Sherwin, Delaney, Kabbaj, Marie-Helene, Wang, Yanchang

    Published in PLoS genetics (25-05-2021)
    “…The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset…”
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  10. 10

    Identification of New Antifungal Agents Targeting Chitin Synthesis by a Chemical-Genetic Method by Li, Yan, Sun, Hongmin, Zhu, Xiaohong, Bian, Cong, Wang, Yanchang, Si, Shuyi

    Published in Molecules (Basel, Switzerland) (29-08-2019)
    “…Fungal infection is a leading cause of mortality in immunocompromised population; thus, it is urgent to develop new and safe antifungal agents. Different from…”
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  11. 11

    The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit by Gutierrez-Morton, Emily, Haluska, Cory, Collins, Liam, Rizkallah, Raed, Tomko, Robert J., Wang, Yanchang

    Published in Cell reports (Cambridge) (23-07-2024)
    “…In budding yeast, the nucleolus serves as the site to sequester Cdc14, a phosphatase essential for mitotic exit. Nucleolar proteins Tof2, Net1, and Fob1 are…”
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  12. 12

    Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin by Chuang, Kun-Han, Liang, Fengshan, Higgins, Ryan, Wang, Yanchang

    Published in Molecular biology of the cell (01-07-2016)
    “…Ubiquilin proteins contain a ubiquitin-like domain (UBL) and ubiquitin-associated domain(s) that interact with the proteasome and ubiquitinated substrates,…”
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  13. 13

    Small molecules targeting Pin1 as potent anticancer drugs by Zhang, Jing, Zhou, Wenwen, Chen, Yunyu, Wang, Yanchang, Guo, Zongru, Hu, Wenhui, Li, Yan, Han, Xiaomin, Si, Shuyi

    Published in Frontiers in pharmacology (27-03-2023)
    “…Pin1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase (PPIase) family of proteins. Following phosphorylation, Pin1-catalyzed…”
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  14. 14

    The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins by Higgins, Ryan, Kabbaj, Marie-Helene, Hatcher, Alexa, Wang, Yanchang

    Published in PloS one (18-01-2018)
    “…The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding and aggregation. Heat shock…”
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  15. 15

    Identification of a Compound That Inhibits the Growth of Gram-Negative Bacteria by Blocking BamA–BamD Interaction by Li, Yan, Zhu, Xiaohong, Zhang, Jing, Lin, Yuan, You, Xuefu, Chen, Minghua, Wang, Yanchang, Zhu, Ningyu, Si, Shuyi

    Published in Frontiers in microbiology (19-06-2020)
    “…The demand for novel antibiotics is imperative for drug-resistant Gram-negative bacteria which causes diverse intractable infection disease in clinic. Here, a…”
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  16. 16

    A new layer of regulation is required to silence the DNA damage checkpoint by Wang, Yanchang

    Published in Cell cycle (Georgetown, Tex.) (15-09-2010)
    “…Comment on: Wood MD, et al. Cell Cycle 2010; 9:3354-64…”
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  17. 17

    Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation by Sherwin, Delaney, Huetteman, Abigail, Wang, Yanchang

    Published in Cells (Basel, Switzerland) (07-07-2022)
    “…Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment…”
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  18. 18

    The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis by Higgins, Ryan, Kabbaj, Marie-Helene, Sherwin, Delaney, Howell, Lauren A., Hatcher, Alexa, Tomko, Robert J., Wang, Yanchang

    Published in Cell reports (Cambridge) (14-07-2020)
    “…The accumulation of misfolded proteins is associated with multiple neurodegenerative disorders, but it remains poorly defined how this accumulation causes…”
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  19. 19

    Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase by Bokros, Michael, Gravenmier, Curtis, Jin, Fengzhi, Richmond, Daniel, Wang, Yanchang

    Published in Cell reports (Cambridge) (09-02-2016)
    “…The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation,…”
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    Protocol for high-throughput screening of SARS-CoV-2 main protease inhibitors using a robust fluorescence polarization assay by Zhang, Jing, Yan, Haohao, Yan, Gangan, Liu, Xiaoping, Wang, Yanchang, Chen, Yunyu

    Published in STAR protocols (16-12-2022)
    “…Discovery of efficacious antiviral agents targeting SARS-CoV-2 main protease (Mpro) is of the highest importance to fight against COVID-19. Here, we describe a…”
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