Search Results - "Wang, Yan‐Yi"

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes by Zhang, Wei, Du, Rong-Hui, Li, Bei, Zheng, Xiao-Shuang, Yang, Xing-Lou, Hu, Ben, Wang, Yan-Yi, Xiao, Geng-Fu, Yan, Bing, Shi, Zheng-Li, Zhou, Peng

“…In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that…”
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A pneumonia outbreak associated with a new coronavirus of probable bat origin by Zhou, Peng, Yang, Xing-Lou, Wang, Xian-Guang, Hu, Ben, Zhang, Lei, Zhang, Wei, Si, Hao-Rui, Zhu, Yan, Li, Bei, Huang, Chao-Lin, Chen, Hui-Dong, Chen, Jing, Luo, Yun, Guo, Hua, Jiang, Ren-Di, Liu, Mei-Qin, Chen, Ying, Shen, Xu-Rui, Wang, Xi, Zheng, Xiao-Shuang, Zhao, Kai, Chen, Quan-Jiao, Deng, Fei, Liu, Lin-Lin, Yan, Bing, Zhan, Fa-Xian, Wang, Yan-Yi, Xiao, Geng-Fu, Shi, Zheng-Li

“…Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in…”
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SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response by Fu, Yu-Zhi, Wang, Su-Yun, Zheng, Zhou-Qin, Yi Huang, Li, Wei-Wei, Xu, Zhi-Sheng, Wang, Yan-Yi

“…A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the…”
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TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination by Zhang, Jing, Hu, Ming-Ming, Wang, Yan-Yi, Shu, Hong-Bing

“…Viral infection activates several transcription factors including NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and innate antiviral…”
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African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity by Ran, Yong, Li, Dan, Xiong, Mei-Guang, Liu, Hua-Nan, Feng, Tao, Shi, Zheng-Wang, Li, Yu-Hui, Wu, Huang-Ning, Wang, Su-Yun, Zheng, Hai-Xue, Wang, Yan-Yi

“…ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is sensed by the innate immune system as well as why it is so virulent…”
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Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques by Shan, Chao, Yao, Yan-Feng, Yang, Xing-Lou, Zhou, Yi-Wu, Gao, Ge, Peng, Yun, Yang, Lian, Hu, Xue, Xiong, Jin, Jiang, Ren-Di, Zhang, Hua-Jun, Gao, Xiao-Xiao, Peng, Cheng, Min, Juan, Chen, Ying, Si, Hao-Rui, Wu, Jia, Zhou, Peng, Wang, Yan-Yi, Wei, Hong-Ping, Pang, Wei, Hu, Zheng-Fei, Lv, Long-Bao, Zheng, Yong-Tang, Shi, Zheng-Li, Yuan, Zhi-Ming

“…The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging…”
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TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis by Zhang, Hong-Xia, Xu, Zhi-Sheng, Lin, Hen, Li, Mi, Xia, Tian, Cui, Kaisa, Wang, Su-Yun, Li, Youjun, Shu, Hong-Bing, Wang, Yan-Yi

“…STAT3 is a transcription factor that plays central roles in various physiological processes and its deregulation results in serious diseases including cancer…”
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Dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the CSF1R inhibitor PLX3397 by Wang, Qirun, Wang, Yi‐Yan, Pu, Wen‐Jun, Ma, Xiaohong, Ni, Rong‐Jun

“…Pexidartinib (PLX3397), a colony‐stimulating factor‐1 receptor (CSF1R) inhibitor, is currently in phase 1–3 clinical trials as a treatment for a variety of…”
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SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication by Zheng, Zhou-Qin, Wang, Su-Yun, Xu, Zhi-Sheng, Fu, Yu-Zhi, Wang, Yan-Yi

“…The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is…”
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Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response by Fu, Yu-Zhi, Guo, Yi, Zou, Hong-Mei, Su, Shan, Wang, Su-Yun, Yang, Qing, Luo, Min-Hua, Wang, Yan-Yi

“…Cyclic GMP-AMP synthase (cGAS) senses viral DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the ER-localized…”
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Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients by Xu, Zhi-Sheng, Shu, Ting, Kang, Liang, Wu, Di, Zhou, Xing, Liao, Bo-Wei, Sun, Xiu-Lian, Zhou, Xi, Wang, Yan-Yi

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RNF152 positively regulates TLR/IL‐1R signaling by enhancing MyD88 oligomerization by Xiong, Mei‐Guang, Xu, Zhi‐Sheng, Li, Yu‐Hui, Wang, Su‐Yun, Wang, Yan‐Yi, Ran, Yong

“…Toll‐like receptors (TLRs) are important pattern recognition receptors (PRRs) that are critical for the defense against invading pathogens. IL‐1β is an…”
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Magnetoresistance and Shubnikov-de Haas oscillation in YSb by Yu, Qiao-He, Wang, Yi-Yan, Lou, Rui, Guo, Peng-Jie, Xu, Sheng, Liu, Kai, Wang, Shancai, Xia, Tian-Long

“…YSb crystals are grown and the transport properties under magnetic field are measured. The resistivity exhibits metallic behavior under zero magnetic field and…”
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USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA by Zhang, Hong-Yan, Liao, Bo-Wei, Xu, Zhi-Sheng, Ran, Yong, Wang, Dong-Peng, Yang, Yan, Luo, Wei-Wei, Wang, Yan-Yi

“…Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized…”
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YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking by Ran, Yong, Xiong, Mei-Guang, Xu, Zhi-Sheng, Luo, Wei-Wei, Wang, Su-Yun, Wang, Yan-Yi

“…STING plays central roles in the innate immune response to pathogens that contain DNA. Sensing cytoplasmic DNA by cyclic GMP-AMP synthase produces cyclic…”
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The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling by Zhou, Qian, Lin, Heng, Wang, Suyun, Wang, Shuai, Ran, Yong, Liu, Ying, Ye, Wen, Xiong, Xiaozhe, Zhong, Bo, Shu, Hong-Bing, Wang, Yan-Yi

“…Viral DNA sensing within the cytosol of infected cells activates type I interferon (IFN) expression. MITA/STING plays an essential role in this pathway by…”
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The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA by Zhong, Bo, Zhang, Lu, Lei, Caoqi, Li, Ying, Mao, Ai-Ping, Yang, Yan, Wang, Yan-Yi, Zhang, Xiao-Lian, Shu, Hong-Bing

“…Viral infection activates transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and elicit innate antiviral response…”
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iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA by Luo, Wei-Wei, Li, Shu, Li, Chen, Zheng, Zhou-Qin, Cao, Pan, Tong, Zhen, Lian, Huan, Wang, Su-Yun, Shu, Hong-Bing, Wang, Yan-Yi

“…VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately…”
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PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation by Yan, Bing-Ru, Zhou, Lu, Hu, Ming-Ming, Li, Mi, Lin, Heng, Yang, Yan, Wang, Yan-Yi, Shu, Hong-Bing

“…Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated…”
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E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation by Yang, Yan, Liao, Bing, Wang, Suyun, Yan, Bingru, Jin, Ying, Shu, Hong-Bing, Wang, Yan-Yi

“…Recognition of viral double-stranded RNA by Toll-like receptor 3 (TLR3) triggers activation of the transcription factors NF-κB and interferon regulated factor…”
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