Search Results - "Wang, Y John"

Trehalose: current use and future applications by Ohtake, Satoshi, Wang, Y John

“…Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms that can withstand extended periods of inanimation. Since this…”
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Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies by Zhang, Lin, Yadav, Sandeep, John Wang, Y., Mozziconacci, Olivier, Schӧneich, Christian

“…Purpose L-Histidine (L-His) and polysorbate 20 (PS20) are two excipients frequently included in parenteral products to stabilize biotherapeutics. The objective…”
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Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry by Borisov, Oleg V, Ji, Junyan A, Wang, Y John

“…Polysorbates (PSs), as acquired from manufacturing processes and chemical nature of fatty acids (FAs) used in production of biotherapeutic formulations, are…”
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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point by Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia

“…Recurrent mutations in the spliceosome are observed in several human cancers, but their functional and therapeutic significance remains elusive. SF3B1, the…”
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Light-Induced Histidine Adducts to an IgG1 Molecule Via Oxidized Histidine Residue and the Potential Impact of Polysorbate-20 Concentration by Lei, Ming, Quan, Cynthia, Wang, John. Y., Kao, Yung-Hsiang, Schöneich, Christian

“…Purpose Histidine (His) undergoes light-induced reactions such as oxidation, crosslinking and addition. These reactions are initiated by singlet oxygen ( 1 O 2…”
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Effect of individual Fc methionine oxidation on FcRn binding: Met252 oxidation impairs FcRn binding more profoundly than Met428 oxidation by Gao, Xuan, Ji, Junyan A, Veeravalli, Karthik, Wang, Y John, Zhang, Taylor, Mcgreevy, William, Zheng, Kai, Kelley, Robert F, Laird, Michael W, Liu, Jun, Cromwell, Mary

“…The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three…”
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Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development by Sreedhara, Alavattam, Yin, Jian, Joyce, Michael, Lau, Kimberly, Wecksler, Aaron T., Deperalta, Galahad, Yi, Li, John Wang, Y., Kabakoff, Bruce, Kishore, Ravuri S.K.

“…[Display omitted] Photostability studies are standard stress testing conducted during drug product development of various pharmaceutical compounds, including…”
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Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization by Ji, Junyan A, Zhang, Boyan, Cheng, Wilson, Wang, Y John

“…Recent oxidation events on monoclonal antibody candidates prompted us to investigate the mechanism of oxidation of Met, Trp, and His residues and to search for…”
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An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization by Bommana, Rupesh, Mozziconacci, Olivier, John Wang, Y., Schöneich, Christian

“…Purpose The loss of potency of protein therapeutics can be linked to the oxidation of specific amino acid residues leading to a great variety of oxidative…”
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Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products by Bane, Jessica, Mozziconacci, Olivier, Yi, Li, Wang, Y. John, Sreedhara, Alavattam, Schöneich, Christian

“…Purpose Triply oxidized histidine in an IgG1 monoclonal antibody was noticed when exposed to ICH light conditions. In order to understand the role of light…”
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Monoclonal Antibody Aggregation Associated with Free Radical Induced Oxidation by Zheng, Kai, Ren, Diya, Wang, Y John, Lilyestrom, Wayne, Scherer, Thomas, Hong, Justin K Y, Ji, Junyan A

“…Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact…”
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Analysis of 2,2'-azobis (2-amidinopropane) dihydrochloride degradation and hydrolysis in aqueous solutions by Werber, Jay, Wang, Y John, Milligan, Michael, Li, Xiaohua, Ji, Junyan A

“…2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH), a free radical-generating azo compound, is gaining prominence as a model oxidant in small molecule and…”
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Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment by Wang, Tingting, Kumru, Ozan S, Yi, Li, Wang, Y John, Zhang, Jennifer, Kim, Jae Hyun, Joshi, Sangeeta B, Middaugh, C Russell, Volkin, David B

“…Monoclonal antibody (mAb) fragments are emerging as promising alternatives to full-length mAbs as protein therapeutic candidates. Antigen-binding fragments…”
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Peroxide formation in polysorbate 80 and protein stability by Ha, Emily, Wang, Wei, Wang, Y John

“…Nonionic surfactants are widely used in the development of protein pharmaceuticals. However, the low level of residual peroxides in surfactants can potentially…”
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Diagnosability and Description of a New Subspecies of Indo-Pacific Humpback Dolphin, Sousa Chinensis (Osbeck, 1765), from the Taiwan Strait by Wang, John Y, Yang, Shih Chu, Hung, Samuel K

“…Background Subspecies recognition can affect how people (scientists and non-scientists alike) view organisms and thus has important implications for research…”
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Isomerization of Asp-Asp motif in model peptides and a monoclonal antibody Fab fragment by Yi, Li, Beckley, Nia, Gikanga, Benson, Zhang, Jennifer, Wang, Y John, Chih, Hung-Wei, Sharma, Vikas K

“…Isomerization of aspartyl (Asp or D) residues is a critical degradation route to consider for stable monoclonal antibody formulations. Among the known hotspot…”
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Polar solvents decrease the viscosity of high concentration IgG1 solutions through hydrophobic solvation and interaction: formulation and biocompatibility considerations by Kamerzell, Tim J, Pace, Amanda L, Li, Megan, Danilenko, Dimitry M, McDowell, Michelle, Gokarn, Yatin R, Wang, Y John

“…Low-volume protein dosage forms for subcutaneous injection pose unique challenges to the pharmaceutical scientist. Indeed, high protein concentrations are…”
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Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies by Wakankar, Aditya A, Borchardt, Ronald T, Eigenbrot, Charles, Shia, Steven, Wang, Y. John, Shire, Steve J, Liu, Jun L

“…The aspartic acid residues (Asp) present in the complementarity-determining regions (CDRs) of the light chains of two recombinant monoclonal antibodies (MAbs),…”
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The relative rate of immunoglobulin gamma 1 fragmentation by Kamerzell, Tim J, Li, Megan, Arora, Shaily, Ji, Junyan A, Wang, Y John

“…The physicochemical stability of protein therapeutics is of significant pharmaceutical interest. Immunoglobulin gamma (IgG) hinge region fragmentation has…”
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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization by Connolly, Brian, Patapoff, Thomas W., Wang, Y. John, Moore, Jamie M., Kamerzell, Tim J.

“…Investigating the phase behavior of sugars in ice and lyophilized solids is of significant interest in the pharmaceutical industry. In this study, Raman and…”
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