Search Results - "Wang, Xuncui"

Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway by Jiang, Ting, Cheng, Hui, Su, Jingjing, Wang, Xuncui, Wang, Qiaoxue, Chu, Jun, Li, Qinglin

“…Gastrodin (GAS) is a component of Gastrodia elata Blume, with strong antioxidant activity in neurodegenerative diseases. Ferroptosis is similar to…”
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Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6 by Jiang, Ting, Chu, Jun, Chen, Hejuntao, Cheng, Hui, Su, Jingjing, Wang, Xuncui, Cao, Yin, Tian, Shasha, Li, Qinglin

“…Ferroptosis is a form of necrosis caused by iron-induced accumulation of lipid hydroperoxide, involving several molecular events, and has been implicated in…”
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MPTP‐induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF‐TrkB pathway by Zhu, Guoqi, Li, Junyao, He, Ling, Wang, Xuncui, Hong, Xiaoqi

“…Background and Purpose Mild cognitive deficit in early Parkinson's disease (PD) has been widely studied. Here we have examined the effects of memantine in…”
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Use of Steaming Process to Improve Biochemical Activity of Polygonatum sibiricum Polysaccharides against D-Galactose-Induced Memory Impairment in Mice by Bian, Zhijuan, Li, Congting, Peng, Daiyin, Wang, Xuncui, Zhu, Guoqi

“…Polysaccharide from Polygonatum sibiricum (PSP) possesses antioxidant, antiaging, and neuroprotective activities. However, whether and how the steaming process…”
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Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death by Zhu, Guoqi, Wang, Xuncui, Wu, Shengbing, Li, Qinglin

“…► Puerarin prevents against MPP+-induced cell death through PI3K/Akt signal pathway. ► Puerarin-activated PI3K/Akt signal pathway blocks MPP+-induced p53…”
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Neuroprotective Effects of Puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's Disease Model in Mice by Zhu, Guoqi, Wang, Xuncui, Wu, Shengbing, Li, Xiaoxiang, Li, Qinglin

“…Puerarin, an active component of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep is well‐known for its anti‐oxidative and neuroprotective activities…”
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Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of Alzheimer's disease by Zhou, An, Wu, Hongfei, Pan, Jian, Wang, Xuncui, Li, Jiaming, Wu, Zeyu, Hui, Ailing

“…Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder characterized by memory loss, language impairment, personality changes and…”
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Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease by Zhu, Guoqi, Wang, Xuncui, Chen, Yuefa, Yang, Shu, Cheng, Hui, Wang, Ning, Li, Qinglin

“…Neurodegeneration is one of the primary etiologies in the onset of Parkinson's disease. In the quest for a new antiparkinsonism treatment the potential…”
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Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via downregulation of ERK activation and inhibition of apoptosis by Wang, Xuncui, Zhu, Guoqi, Yang, Shu, Wang, Xiu, Cheng, Hui, Wang, Fei, Li, Xiaoxiang, Li, Qinglin

“…Paeonol, an active component of Moutan Cortex, has been recognized as a potential neuroprotective drug. In the present study, an injury model based on…”
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Study on protective effect of salvianolic acid B on glutamate-induced excitotoxicity in pheochromocytoma PC12 cells by Wang, Xuncui, Zhu, Guoqi

“…To study the protective effect and mechanism of salvianolic acid B (Sal B) on glutamate-induced excito-toxicity. Glutamate-induced PC12 cell injury model was…”
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Shenqi Yizhi prescription prevents AβO-induced memory impairment in mice by regulating the contractility of brain pericytes by Zhao, Panpan, Cheng, Ping, Wang, Jingji, Zhu, Guoqi, Wang, Xuncui

“…Cerebral microcirculation disturbance manifested by decrease of cerebral blood flow (CBF) is one of early features of Alzheimer's disease (AD). Shenqi Yizhi…”
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Polysaccharides from Polygonatum cyrtonema Hua prevent post-traumatic stress disorder behaviors in mice: Mechanisms from the perspective of synaptic injury, oxidative stress, and neuroinflammation by Xie, Pan, Chen, Lixia, Wang, Juan, Wang, Xuncui, Yang, Shaojie, Zhu, Guoqi

“…ETHNOPHARMACOLOGICAL RELEVANCEAccording to traditional Chinese medicine (TCM) theory, post-traumatic stress disorder (PTSD) is a kind of depression syndrome,…”
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Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD by Wang, Juan, Gao, Feng, Cui, Shuai, Yang, Shaojie, Gao, Fang, Wang, Xuncui, Zhu, Guoqi

“…Astrocytic functions and brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signaling pathways are impaired in stress-related…”
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Astragaloside IV prevents Aβ1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway by Wang, Xuncui, Xu, Wen, Chen, Hejuntao, Li, Weizu, Li, Weiping, Zhu, Guoqi

“…•Astragaloside IV promotes BDNF expression and phosphorylation of TrkB.•AS-IV, a natural PPARγ agonist, promotes the release of BDNF by targeting PPARγ.•AS-IV…”
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Neurovascular glial unit: A target of phytotherapy for cognitive impairments by Chen, Lixia, Zhen, Yilan, Wang, Xuncui, Wang, Jingji, Zhu, Guoqi

“…Neurovascular glial unit (NVGU) dysfunction has been reported to be an early and critical event in the pathophysiology of Alzheimer's disease (AD) and vascular…”
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Exploring the effect of Anshen Dingzhi prescription on hippocampal mitochondrial signals in single prolonged stress mouse model by Wang, Juan, Zhao, Panpan, Cheng, Ping, Zhang, Zhengrong, Yang, Shaojie, Wang, Jingji, Wang, Xuncui, Zhu, Guoqi

“…Anshen Dingzhi prescription (ADP), which was first published in the masterpiece of traditional Chinese Medicine in the Qing Dynasty, "Yi Xue Xin Wu" (1732 CE),…”
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Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses by Hu, Jiamin, Li, Haipeng, Wang, Xuncui, Cheng, Hongliang, Zhu, Guoqi, Yang, Shaojie

“…Anshen Dingzhi prescription (ADP), documented in “Yi Xue Xin Wu”, is a famous prescription for treating panic-related mental disorders such as post-traumatic…”
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Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling by Ji, Manman, Zhang, Zhengrong, Gao, Feng, Yang, Shaojie, Wang, Juan, Wang, Xuncui, Zhu, Guoqi

“…Chronic traumatic stress results in various psychiatric disorders, especially posttraumatic stress disorder (PTSD). Previous study demonstrated that…”
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Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice by Song, Zhujin, Bian, Zhijuan, Zhang, Zhengrong, Wang, Xuncui, Zhu, Aisong, Zhu, Guoqi

“…The activation of Nod-like receptor protein 3 (NLRP3) inflammasome propagates pro-inflammatory signaling cascades linking to depression-like behaviors…”
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Tenuifolin in the prevention of Alzheimer's disease-like phenotypes: Investigation of the mechanisms from the perspectives of calpain system, ferroptosis, and apoptosis by Li, Congting, Gao, Feng, Qu, Yan, Zhao, Panpan, Wang, Xuncui, Zhu, Guoqi

“…Polygala tenuifolia was documented to calm the mind and promote wisdom. However, its underlying mechanisms are still unclear. This study aimed to investigate…”
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