Search Results - "Wang, Xiao‐Fan"

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression by Huang, De, Wang, Yan, Thompson, J. Will, Yin, Tao, Alexander, Peter B., Qin, Diyuan, Mudgal, Poorva, Wu, Haiyang, Liang, Yaosi, Tan, Lianmei, Pan, Christopher, Yuan, Lifeng, Wan, Ying, Li, Qi-Jing, Wang, Xiao-Fan

“…Many cancers have an unusual dependence on glutamine. However, most previous studies have focused on the contribution of glutamine to metabolic building blocks…”
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Notch Promotes Radioresistance of Glioma Stem Cells by Wang, Jialiang, Wakeman, Timothy P., Lathia, Justin D., Hjelmeland, Anita B., Wang, Xiao‐Fan, White, Rebekah R., Rich, Jeremy N., Sullenger, Bruce A.

“…Radiotherapy represents the most effective nonsurgical treatments for gliomas. However, gliomas are highly radioresistant and recurrence is nearly universal…”
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miR-126 and miR-126 repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis by Zhang, Yun, Yang, Pengyuan, Sun, Tao, Li, Dong, Xu, Xin, Rui, Yaocheng, Li, Chaoran, Chong, Mengyang, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Lu, Xincheng, Xie, Dong, Li, Qi-Jing, Wang, Xiao-Fan

“…The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms…”
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CD36 initiates the secretory phenotype during the establishment of cellular senescence by Chong, Mengyang, Yin, Tao, Chen, Rui, Xiang, Handan, Yuan, Lifeng, Ding, Yi, Pan, Christopher C, Tang, Zhen, Alexander, Peter B, Li, Qi‐Jing, Wang, Xiao‐Fan

“…Cellular senescence is a unique cell fate characterized by stable proliferative arrest and the extensive production and secretion of various inflammatory…”
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Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases by Wakeman, Timothy P, Wang, Qinhong, Feng, Junjie, Wang, Xiao-Fan

“…The methyltransferase DOT1L methylates histone H3 at K79 to facilitate specific biological events. H3K79 dimethylation (H3K79‐2Me) by DOT1L influences the DNA…”
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Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth by Wang, Hui, Lathia, Justin D., Wu, Qiulian, Wang, Jialiang, Li, Zhizhong, Heddleston, John M., Eyler, Christine E., Elderbroom, Jennifer, Gallagher, Joseph, Schuschu, Jesse, MacSwords, Jennifer, Cao, Yiting, McLendon, Roger E., Wang, Xiao‐Fan, Hjelmeland, Anita B., Rich, Jeremy N.

“…Glioblastomas are the most common and most lethal primary brain tumor. Recent studies implicate an important role for a restricted population of neoplastic…”
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Cellular senescence: from anti-cancer weapon to anti-aging target by Yuan, Lifeng, Alexander, Peter B., Wang, Xiao-Fan

“…Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies…”
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Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis by Li, Jing-Jing, Yin, Hong-Kun, Guan, Dong-Xian, Zhao, Jiang-Sha, Feng, Yu-Xiong, Deng, Yue-Zhen, Wang, Xiang, Li, Nan, Wang, Xiao-Fan, Cheng, Shu-Qun, Bao, Ying, Xie, Dong

“…Background Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. Methods Chemerin…”
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PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling by Ma, Ning, Wang, Yi-Kang, Xu, Sheng, Ni, Qian-Zhi, Zheng, Qian-Wen, Zhu, Bing, Cao, Hui-Jun, Jiang, Hao, Zhang, Feng-Kun, Yuan, Yan-Mei, Zhang, Er-Bin, Chen, Tian-Wei, Xia, Ji, Ding, Xu-Fen, Chen, Zhen-Hua, Zhang, Xiu-Ping, Wang, Kang, Cheng, Shu-Qun, Qiu, Lin, Li, Zhi-Gang, Yu, Yong-Chun, Wang, Xiao-Fan, Zhou, Bin, Li, Jing-Jing, Xie, Dong

“…Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease in the world, however, no drug treatment has been approved for…”
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Parkin coordinates mitochondrial lipid remodeling to execute mitophagy by Lin, Chao‐Chieh, Yan, Jin, Kapur, Meghan D, Norris, Kristi L, Hsieh, Cheng‐Wei, Huang, De, Vitale, Nicolas, Lim, Kah‐Leong, Guan, Ziqiang, Wang, Xiao‐Fan, Chi, Jen‐Tsan, Yang, Wei‐Yuan, Yao, Tso‐Pang

“…Autophagy has emerged as the prime machinery for implementing organelle quality control. In the context of mitophagy, the ubiquitin E3 ligase Parkin tags…”
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Disruption of pollination by herbivores is rescued by nectar yeasts by Deng, Guo‐Cui, Dai, Can, Song, Qing‐Qing, Zhang, You‐Xuan, Zhang, Xiao‐Xiao, Wang, Xiao‐Fan, Gong, Yan‐Bing

“…Attracting pollinators to achieve successful reproduction is a key challenge for wild plants that may be disturbed by complex multispecies interactions in…”
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The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways by Hrgovic, Igor, Doll, Monika, Kleemann, Johannes, Wang, Xiao-Fan, Zoeller, Nadja, Pinter, Andreas, Kippenberger, Stefan, Kaufmann, Roland, Meissner, Markus

“…The formation of new lymphatic vessels provides an additional route for tumour cells to metastasize. Therefore, inhibiting lymphangiogenesis represents an…”
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CHML promotes liver cancer metastasis by facilitating Rab14 recycle by Chen, Tian-Wei, Yin, Fen-Fen, Yuan, Yan-Mei, Guan, Dong-Xian, Zhang, Erbin, Zhang, Feng-Kun, Jiang, Hao, Ma, Ning, Wang, Jing-Jing, Ni, Qian-Zhi, Qiu, Lin, Feng, Jing, Zhang, Xue-Li, Bao, Ying, Wang, Kang, Cheng, Shu-Qun, Wang, Xiao-Fan, Wang, Xiang, Li, Jing-Jing, Xie, Dong

“…Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely…”
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MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B by Hu, Jing, Sun, Tao, Wang, Hui, Chen, Zhengxin, Wang, Shuai, Yuan, Lifeng, Liu, Tingyu, Li, Hai-Ri, Wang, Pingping, Feng, Yukuan, Wang, Qinhong, McLendon, Roger E., Friedman, Allan H., Keir, Stephen T., Bigner, Darell D., Rathmell, Jeff, Fu, Xiang-dong, Li, Qi-Jing, Wang, Huibo, Wang, Xiao-Fan

“…The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that are critical for glioblastoma (GBM) occurrence and…”
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Cilia loss sensitizes cells to transformation by activating the mevalonate pathway by Deng, Yue-Zhen, Cai, Zhen, Shi, Shuo, Jiang, Hao, Shang, Yu-Rong, Ma, Ning, Wang, Jing-Jing, Guan, Dong-Xian, Chen, Tian-Wei, Rong, Ye-Fei, Qian, Zhen-Yu, Zhang, Er-Bin, Feng, Dan, Zhou, Quan-Li, Du, Yi-Nan, Liu, Dong-Ping, Huang, Xing-Xu, Liu, Lu-Ming, Chin, Eugene, Li, Dang-Sheng, Wang, Xiao-Fan, Zhang, Xue-Li, Xie, Dong

“…Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown…”
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Essential role of smad3 in infarct healing and in the pathogenesis of cardiac remodeling by BUJAK, Marcin, GUOFENG REN, HYUK JUNG KWEON, DOBACZEWSKI, Marcin, REDDY, Anilkumar, TAFFET, George, WANG, Xiao-Fan, FRANGOGIANNIS, Nikolaos G

“…Postinfarction cardiac repair is regulated through timely activation and repression of inflammatory pathways, followed by transition to fibrous tissue…”
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Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice by Biernacka, Anna, Cavalera, Michele, Wang, Junhong, Russo, Ilaria, Shinde, Arti, Kong, Ping, Gonzalez-Quesada, Carlos, Rai, Vikrant, Dobaczewski, Marcin, Lee, Dong-Wook, Wang, Xiao-Fan, Frangogiannis, Nikolaos G

“…Heart failure in diabetics is associated with cardiac hypertrophy, fibrosis and diastolic dysfunction. Activation of transforming growth factor-β/Smad3…”
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Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death by Yuan, Lifeng, Zhai, Linhui, Qian, Lili, Huang, De, Ding, Yi, Xiang, Handan, Liu, Xiaojing, Thompson, J. Will, Liu, Juan, He, Yong-Han, Chen, Xiao-Qiong, Hu, Jing, Kong, Qing-Peng, Tan, Minjia, Wang, Xiao-Fan

“…Cellular senescence is a fundamental cell fate playing a significant role throughout the natural aging process. However, the molecular determinants…”
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Asymmetrical Low-RCS FSS-Based Antenna for Tri-Band Shared-Aperture Array by Chen, Jian-Xin, Wang, Xiao-Fan, Yang, Ling-Ling, Wang, Xue-Ren, Gu, Xiao-Feng, Yang, Wen-Wen

“…This letter proposes an asymmetrical low-radar cross section (RCS) frequency selective surface (FSS)-based low-band (LB: 1.7-2.7 GHz) antenna for the…”
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Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers by Ding, Yi, Gong, Chang, Huang, De, Chen, Rui, Sui, Pinpin, Lin, Kevin H., Liang, Gehao, Yuan, Lifeng, Xiang, Handan, Chen, Junying, Yin, Tao, Alexander, Peter B., Wang, Qian-Fei, Song, Er-Wei, Li, Qi-Jing, Wood, Kris C., Wang, Xiao-Fan

“…Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle in the clinic, limiting its efficacy. However, the biological basis for…”
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