Search Results - "Wang, Tony T"

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus by Liu, Shufeng, DeLalio, Leon J, Isakson, Brant E, Wang, Tony T

“…RATIONALE:The mosquito-borne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question about how the virus gets into human…”
Get full text

HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters by Jana, Sirsendu, Heaven, Michael R, Stauft, Charles B, Wang, Tony T, Williams, Matthew C, D'Agnillo, Felice, Alayash, Abdu I

“…The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible…”
Get full text

Distinct susceptibility and applicability of MDCK derivatives for influenza virus research by Lin, Shih-Chao, Kappes, Matthew A, Chen, Mei-Chun, Lin, Chi-Chen, Wang, Tony T

“…Madin-Darby Canine Kidney (MDCK) cells are widely utilized as a substrate for influenza virus isolation and propagation due to the high yields of virus. Here…”
Get full text

Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants by Stauft, Charles B., Selvaraj, Prabhuanand, D’Agnillo, Felice, Meseda, Clement A., Liu, Shufeng, Pedro, Cyntia L., Sangare, Kotou, Lien, Christopher Z., Weir, Jerry P., Starost, Matthew F., Wang, Tony T.

“…Detection of secretory antibodies in the airway is highly desirable when evaluating mucosal protection by vaccines against a respiratory virus, such as the…”
Get full text

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells by Caohuy, Hung, Eidelman, Ofer, Chen, Tinghua, Liu, Shufeng, Yang, Qingfeng, Bera, Alakesh, Walton, Nathan I., Wang, Tony T., Pollard, Harvey B.

“…To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary…”
Get full text

Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters by Liu, Shufeng, Stauft, Charles B., Selvaraj, Prabhuanand, Chandrasekaran, Prabha, D’Agnillo, Felice, Chou, Chao-Kai, Wu, Wells W., Lien, Christopher Z., Meseda, Clement A., Pedro, Cyntia L., Starost, Matthew F., Weir, Jerry P., Wang, Tony T.

“…Few live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are in pre-clinical or clinical development. We seek to attenuate…”
Get full text

Identification of salivary gland escape barriers to western equine encephalitis virus in the natural vector, Culex tarsalis by Stauft, Charles B, Phillips, Aaron T, Wang, Tony T, Olson, Kenneth E

“…Herein we describe a previously uninvestigated salivary gland escape barrier (SEB) in Culex tarsalis mosquitoes infected with two different strains of Western…”
Get full text

Monocyte chemotactic protein–induced protein 1 controls allergic airway inflammation by suppressing IL-5–producing TH2 cells through the Notch/Gata3 pathway by Peng, Hui, Ning, Huan, Wang, Qinghong, Lu, Wenbao, Chang, Yingzi, Wang, Tony T., Lai, Jinping, Kolattukudy, Pappachan E., Hou, Rong, Hoft, Daniel F., Dykewicz, Mark S., Liu, Jianguo

“…Asthmatic and allergic inflammation is mediated by TH2 cytokines (IL-4, IL-5, and IL-13). Although we have learned much about how TH2 cells are differentiated,…”
Get full text

Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation by Huang, Shengping, Liu, Shufeng, Fu, Jia J., Tony Wang, T., Yao, Xiaolan, Kumar, Anil, Liu, Gang, Fu, Mingui

“…It was recently demonstrated that MCPIP1 is a critical factor that controls inflammation and immune homeostasis; however, the relationship between MCPIP1 and…”
Get full text

Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23 by Bertuccio, Claudia A, Wang, Tony T, Hamilton, Kirk L, Rodriguez-Gil, Diego J, Condliffe, Steven B, Devor, Daniel C

“…We previously demonstrated endocytosis of KCa2.3 is caveolin-1-, dynamin II- and Rab5-dependent. KCa2.3 then enters Rab35/EPI64C- and RME-1-containing…”
Get full text

SARS-CoV-2 B.1.1.7 Infection of Syrian Hamster Does Not Cause More Severe Disease, and Naturally Acquired Immunity Confers Protection by Nuñez, Ivette A, Lien, Christopher Z, Selvaraj, Prabhuanand, Stauft, Charles B, Liu, Shufeng, Starost, Matthew F, Wang, Tony T

“…Epidemiological studies have revealed the emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC),…”
Get full text

MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge by Meseda, Clement A., Stauft, Charles B., Selvaraj, Prabhuanand, Lien, Christopher Z., Pedro, Cyntia, Nuñez, Ivette A., Woerner, Amy M., Wang, Tony T., Weir, Jerry P.

“…Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development. The majority of vaccine candidates to date…”
Get full text

Comparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver Cells by Liu, Shufeng, Zhao, Ting, Song, BenBen, Zhou, Jianhua, Wang, Tony T

“…Hepatitis C virus (HCV) poses a global threat to public health. HCV envelop protein E2 is the major component on the virus envelope, which plays an important…”
Get full text

RNA sensors of the innate immune system and their detection of pathogens by Chen, Nanhua, Xia, Pengpeng, Li, Shuangjie, Zhang, Tangjie, Wang, Tony T., Zhu, Jianzhong

“…Summary The innate immune system plays a critical role in pathogen recognition and initiation of protective immune response through the recognition of pathogen…”
Get full text

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway by Liu, Shufeng, Wang, Wenyu, Brown, Lauren E., Qiu, Chao, Lajkiewicz, Neil, Zhao, Ting, Zhou, Jianhua, Porco, John A., Wang, Tony T.

“…Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection…”
Get full text

Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro by Stauft, Charles B, Sangare, Kotou, Wang, Tony T

“…Abstract Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and…”
Get full text

Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice by Liu, Shufeng, Selvaraj, Prabhuanand, Sangare, Kotou, Luan, Binquan, Wang, Tony T.

“…Despite being more transmissible, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant only causes milder diseases in laboratory…”
Get full text

The TRAF3-DYRK1A-RAD54L2 complex maintains ACE2 expression to promote SARS-CoV-2 infection by Mao, Dexin, Liu, Shufeng, Phan, An Thanh, Renner, Stephanie, Sun, Yan, Wang, Tony T, Zhu, Yiping

“…Angiotensin converting enzyme 2 (ACE2), the host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is differentially…”
Get full text

Effective inhibition of MERS-CoV infection by resveratrol by Lin, Shih-Chao, Ho, Chi-Tang, Chuo, Wen-Ho, Li, Shiming, Wang, Tony T, Lin, Chi-Chen

“…Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no…”
Get full text

Structure–Function Analysis of Resistance to Bamlanivimab by SARS-CoV‑2 Variants Kappa, Delta, and Lambda by Liu, Shufeng, Huynh, Tien, Stauft, Charles B, Wang, Tony T, Luan, Binquan

“…The newly emerging Kappa, Delta, and Lambda SARS-CoV-2 variants are worrisome, characterized with the double mutations E484Q/L452R, T478K/L452R, and…”
Get full text