Search Results - "Wang, Shangzi"

Molecular subtyping of esophageal squamous cell carcinoma by large-scale transcriptional profiling: Characterization, therapeutic targets, and prognostic value by Wang, Danke, Dai, Jiacheng, Suo, Chen, Wang, Shangzi, Zhang, Yuting, Chen, Xingdong

“…The tumor heterogeneity of the transcriptional profiles is independent of genetic variation. Several studies have successfully identified esophageal squamous…”
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The Clinical Potential of Targeted Nanomedicine: Delivering to Cancer Stem-like Cells by Kim, Sang-Soo, Rait, Antonina, Rubab, Farwah, Rao, Abhi K, Kiritsy, Michael C, Pirollo, Kathleen F, Wang, Shangzi, Weiner, Louis M, Chang, Esther H

“…Cancer stem-like cells (CSCs) have been implicated in recurrence and treatment resistance in many human cancers. Thus, a CSC-targeted drug delivery strategy to…”
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Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project by Gong, Binsheng, Li, Dan, Zhang, Yifan, Kusko, Rebecca, Lababidi, Samir, Cao, Zehui, Chen, Mingyang, Chen, Ning, Chen, Qiaochu, Chen, Qingwang, Dai, Jiacheng, Gan, Qiang, Gao, Yuechen, Guo, Mingkun, Hariani, Gunjan, He, Yujie, Hou, Wanwan, Jiang, He, Kushwaha, Garima, Li, Jian-Liang, Li, Jianying, Li, Yulan, Liu, Liang-Chun, Liu, Ruimei, Liu, Shiming, Meriaux, Edwin, Mo, Mengqing, Moore, Mathew, Moss, Tyler J., Niu, Quanne, Patel, Ananddeep, Ren, Luyao, Saremi, Nedda F., Shang, Erfei, Shang, Jun, Song, Ping, Sun, Siqi, Urban, Brent J., Wang, Danke, Wang, Shangzi, Wen, Zhining, Xiong, Xiangyi, Yang, Jingcheng, Yin, Lihui, Zhang, Chao, Zhang, Ruolan, Bhandari, Ambica, Cai, Wanshi, Eterovic, Agda Karina, Megherbi, Dalila B., Shi, Tieliu, Suo, Chen, Yu, Ying, Zheng, Yuanting, Novoradovskaya, Natalia, Sears, Renee L., Shi, Leming, Jones, Wendell, Tong, Weida, Xu, Joshua

“…Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling…”
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DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma by Fitzgerald, Allison A, Wang, Shangzi, Agarwal, Veena, Marcisak, Emily F, Zuo, Annie, Jablonski, Sandra A, Loth, Melanie, Fertig, Elana J, MacDougall, John, Zhukovsky, Eugene, Trivedi, Shubhendu, Bhatia, Dimple, O'Neill, Vince, Weiner, Louis M

“…BackgroundPancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors…”
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Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient by Zheng, Yuanting, Li, Bingying, Pan, Dejing, Cao, Jun, Zhang, Jian, Wang, Xiaolin, Li, Xiangnan, Hou, Wanwan, Bao, Ding, Ren, Luyao, Yang, Jingcheng, Wang, Shangzi, Qiu, Yangyang, Zhou, Fei, Liu, Zhiwei, Zhu, Sibo, Zhang, Lei, Qing, Tao, Wang, Yi, Yu, Ying, Wu, Jiaxue, Hu, Xichun, Shi, Leming

“…We identified a rare missense germline mutation in BARD1 (c.403G>A or p.Asp135Asn) as pathogenic using integrated genomics and transcriptomics profiling of…”
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Effective antibody therapy induces host-protective antitumor immunity that is augmented by TLR4 agonist treatment by Wang, Shangzi, Astsaturov, Igor A., Bingham, Catherine A., McCarthy, Kenneth M., von Mehren, Margaret, Xu, Wei, Alpaugh, R. Katherine, Tang, Yong, Littlefield, Bruce A., Hawkins, Lynn D., Ishizaka, Sally T., Weiner, Louis M.

“…Toll-like receptors are potent activators of the innate immune system and generate signals leading to the initiation of the adaptive immune response that can…”
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Monoclonal antibodies: versatile platforms for cancer immunotherapy by Weiner, Louis M, Surana, Rishi, Wang, Shangzi

“…Key Points The past century has witnessed the evolution of the 'magic bullet' from concept to clinical reality. Therapeutic antibodies have been established as…”
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Chromatin interaction maps identify oncogenic targets of enhancer duplications in cancer by Song, Yueqiang, Li, Fuyuan, Wang, Shangzi, Wang, Yuntong, Lai, Cong, Chen, Lian, Jiang, Ning, Li, Jin, Chen, Xingdong, Bailey, Swneke D, Zhang, Xiaoyang

“…As a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that…”
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Abstract LB-133: De novo expression of gastrin and CCK-B receptors in cell lines derived from KPC mice by Smith, Jill P., Wang, Shangzi, Weiner, Louis, Nadella, Sandeep

“…Abstract Background: Animal models to study cancer progression and therapeutics are essential but these animal models are most useful when they resemble human…”
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Abstract 6636: Therapy with BXCL701 (B), a DPP8, DPP9, DPPIV and FAP inhibitor, in combination with anti-PD1 antibody (PD1) in a syngeneic murine pancreatic ductal adenocarcinoma (PDAC) model improves treatment outcomes and induces intratumoral NK cell infiltrates and a marked reduction in tumor stromal fibrosis by Wang, Shangzi, Fitzgerald, Allison, Ajina, Reham, Jablonsk, Sandra A., Weiner, Louis M., MacDougall, John, Agarwal, Veena, O'Neill, Vince J.

“…Abstract PDAC is typically resistant to chemotherapy and immunotherapy; therefore, novel strategies are needed to enhance therapeutic response. BXCL701 is a…”
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Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice by Smith, Jill P., Wang, Shangzi, Nadella, Sandeep, Jablonski, Sandra A., Weiner, Louis M.

“…Advanced pancreatic ductal adenocarcinoma (PDAC) has typically been resistant to chemotherapy and immunotherapy; therefore, novel strategies are needed to…”
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Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases by Osborne, Nicholas, Sundseth, Rebecca, Gay, Martha D, Cao, Hong, Tucker, Robin D, Nadella, Sandeep, Wang, Shangzi, Liu, Xunxian, Kroemer, Alexander, Sutton, Lynda, Cato, Allen, Smith, Jill P

“…Growth of pancreatic cancer is stimulated by gastrin in both a paracrine and an autocrine fashion. Traditional therapies have not significantly improved…”
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Combination therapy with immune checkpoint inhibitor and CCK-receptor blockade increases survival in pancreatic cancer by Smith, Jill, Wang, Shangzi, Nadella, Sandeep, Jablonski, Sandra, Weiner, Louis

“…Results: Monotherapy with CCKR blockade significantly decreased tumor size and metastases in SCID mice with orthotopic PDAC. Tumor immuno-histochemical…”
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Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions by Gong, Binsheng, Li, Dan, Kusko, Rebecca, Novoradovskaya, Natalia, Zhang, Yifan, Wang, Shangzi, Pabón-Peña, Carlos, Zhang, Zhihong, Lai, Kevin, Cai, Wanshi, LoCoco, Jennifer S, Lader, Eric, Richmond, Todd A, Mittal, Vinay K, Liu, Liang-Chun, Johann, Jr, Donald J, Willey, James C, Bushel, Pierre R, Yu, Ying, Xu, Chang, Chen, Guangchun, Burgess, Daniel, Cawley, Simon, Giorda, Kristina, Haseley, Nathan, Qiu, Fujun, Wilkins, Katherine, Arib, Hanane, Attwooll, Claire, Babson, Kevin, Bao, Longlong, Bao, Wenjun, Lucas, Anne Bergstrom, Best, Hunter, Bhandari, Ambica, Bisgin, Halil, Blackburn, James, Blomquist, Thomas M, Boardman, Lisa, Burgher, Blake, Butler, Daniel J, Chang, Chia-Jung, Chaubey, Alka, Chen, Tao, Chierici, Marco, Chin, Christopher R, Close, Devin, Conroy, Jeffrey, Cooley Coleman, Jessica, Craig, Daniel J, Crawford, Erin, Del Pozo, Angela, Deveson, Ira W, Duncan, Daniel, Eterovic, Agda Karina, Fan, Xiaohui, Foox, Jonathan, Furlanello, Cesare, Ghosal, Abhisek, Glenn, Sean, Guan, Meijian, Haag, Christine, Hang, Xinyi, Happe, Scott, Hennigan, Brittany, Hipp, Jennifer, Hong, Huixiao, Horvath, Kyle, Hu, Jianhong, Hung, Li-Yuan, Jarosz, Mirna, Kerkhof, Jennifer, Kipp, Benjamin, Kreil, David Philip, Łabaj, Paweł, Lapunzina, Pablo, Li, Peng, Li, Quan-Zhen, Li, Weihua, Li, Zhiguang, Liang, Yu, Liu, Shaoqing, Liu, Zhichao, Ma, Charles, Marella, Narasimha, Martín-Arenas, Rubén, Megherbi, Dalila B, Meng, Qingchang, Mieczkowski, Piotr A, Morrison, Tom, Muzny, Donna, Ning, Baitang, Parsons, Barbara L, Paweletz, Cloud P, Pirooznia, Mehdi, Qu, Wubin, Raymond, Amelia, Rindler, Paul, Ringler, Rebecca, Sadikovic, Bekim

“…Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing…”
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Functional consequences of a rare missense BARD1 c.403GA germline mutation identified in a triple-negative breast cancer patient by Zheng, Yuanting, Li, Bingying, Pan, Dejing, Cao, Jun, Zhang, Jian, Wang, Xiaolin, Li, Xiangnan, Hou, Wanwan, Bao, Ding, Ren, Luyao, Yang, Jingcheng, Wang, Shangzi, Qiu, Yangyang, Zhou, Fei, Liu, Zhiwei, Zhu, Sibo, Zhang, Lei, Qing, Tao, Wang, Yi, Yu, Ying, Wu, Jiaxue, Hu, Xichun, Shi, Leming

“…We identified a rare missense germline mutation in BARD1 (c.403G>A or p.Asp135Asn) as pathogenic using integrated genomics and transcriptomics profiling of…”
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Abstract 4023: Combination therapy with immune checkpoint inhibitor and CCK-receptor blockade increases survival of pancreatic cancer by Smith, Jill P., Wang, Shangzi, Reham, Ajina, Jablonski, Sandra A., Weiner, Louis M.

“…Abstract Introduction: Advanced pancreatic ductal adenocarcinoma (PDAC) has typically been resistant to chemotherapy and immune therapy; therefore, novel…”
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Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance by Ajina, Reham, Malchiodi, Zoe X, Fitzgerald, Allison A, Zuo, Annie, Wang, Shangzi, Moussa, Maha, Cooper, Connor J, Shen, Yue, Johnson, Quentin R, Parks, Jerry M, Smith, Jeremy C, Catalfamo, Marta, Fertig, Elana J, Jablonski, Sandra A, Weiner, Louis M

“…Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Pancreatic tumors are minimally infiltrated by T cells…”
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Antibodies and cancer therapy: versatile platforms for cancer immunotherapy by Weiner, Louis M., Surana, Rishi, Wang, Shangzi

“…Antibodies have emerged as important therapeutics for cancer. Recently, it has become clear that antibodies possess multiple clinically relevant mechanisms of…”
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Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy by Kim, B, Wang, S, Lee, J M, Jeong, Y, Ahn, T, Son, D-S, Park, H W, Yoo, H-s, Song, Y-J, Lee, E, Oh, Y M, Lee, S B, Choi, J, Murray, J C, Zhou, Y, Song, P H, Kim, K-A, Weiner, L M

“…Met is a receptor tyrosine kinase that promotes cancer progression. In addition, Met has been implicated in resistance of tumors to various targeted therapies…”
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IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model by Surana, Rishi, Wang, Shangzi, Xu, Wei, Jablonski, Sandra A, Weiner, Louis M

“…Tumor-targeted antibody therapy has had a major impact on reducing morbidity and mortality in a wide range of cancers. Antibodies mediate their antitumor…”
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