Search Results - "Wang, Shangfeng"
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Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Published in Nature communications (05-03-2019)“…The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window…”
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Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing
Published in Angewandte Chemie International Edition (11-06-2019)“…Small‐molecule organic fluorophores, spectrally active in the 900–1700 nm region, with tunable wavelength and sensing properties are sought‐after for in vivo…”
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NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Published in Nature communications (21-08-2020)“…Bioluminescence imaging has been widely used in life sciences and biomedical applications. However, conventional bioluminescence imaging usually operates in…”
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Molecular Fluorophores for Deep-Tissue Bioimaging
Published in ACS central science (26-08-2020)“…Fluorescence imaging has made tremendous inroads toward understanding the complexity of biological systems, but in vivo deep-tissue imaging remains a great…”
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NIR‐II Chemiluminescence Molecular Sensor for In Vivo High‐Contrast Inflammation Imaging
Published in Angewandte Chemie International Edition (12-10-2020)“…Chemiluminescence (CL) sensing without external excitation by light and autofluorescence interference has been applied to high‐contrast in vitro immunoassays…”
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Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring
Published in Analytical chemistry (Washington) (02-04-2019)“…Drug-induced hepatotoxicity represents an important challenge for safety in drug development. The production of peroxynitrite (ONOO–) is proposed as an early…”
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Ultra-photostable small-molecule dyes facilitate near-infrared biophotonics
Published in Nature communications (22-03-2024)“…Long-wavelength, near-infrared small-molecule dyes are attractive in biophotonics. Conventionally, they rely on expanded aromatic structures for redshift,…”
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Azo Pigments Make Raman Spectral Multiplexing More Sensitive
Published in ACS central science (26-05-2021)“…An azo-conjugated strategy to enhance Raman signals of vibrational bonds proves the giant potential of molecular engineering for ultrasensitive Raman…”
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Er3+ Sensitized 1530 nm to 1180 nm Second Near‐Infrared Window Upconversion Nanocrystals for In Vivo Biosensing
Published in Angewandte Chemie International Edition (18-06-2018)“…Fluorescent bioimaging in the second near‐infrared window (NIR‐II) can probe deep tissue with minimum auto‐fluorescence and tissue scattering. However, current…”
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Optical Multiplexed Bioassays for Improved Biomedical Diagnostics
Published in Angewandte Chemie International Edition (16-09-2019)“…Conventional analytical methods based on the detection of a single disease marker may not be sufficiently accurate because the progression of disease generally…”
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ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing
Published in Angewandte Chemie International Edition (06-12-2021)“…Inflammation usually results in high‐level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline…”
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Counterion‐Paired Bright Heptamethine Fluorophores with NIR‐II Excitation and Emission Enable Multiplexed Biomedical Imaging
Published in Angewandte Chemie International Edition (13-06-2022)“…Photon excitation and emission at the NIR‐II spectral window enable high‐contrast deep‐tissue bioimaging. However, multiplexed imaging with NIR‐II excitation…”
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In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission
Published in Nano letters (10-04-2019)“…Quantitatively imaging the spatiotemporal distribution of biological events in living organisms is essential to understand fundamental biological processes…”
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NIR‐II pH Sensor with a FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization
Published in Angewandte Chemie International Edition (01-03-2021)“…Monitoring the pH in tumor lesions provides abundant physiological information. However, currently developed pH sensors only achieve sensitive detection in the…”
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Supramolecularly Engineered NIR‐II and Upconversion Nanoparticles In Vivo Assembly and Disassembly to Improve Bioimaging
Published in Advanced materials (Weinheim) (01-12-2018)“…Contrast agents for bioimaging suffer from low accumulation at lesion area and high uptake in the reticuloendothelial system (RES). Assembly of nanoparticles…”
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A Bright, Renal‐Clearable NIR‐II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging
Published in Angewandte Chemie International Edition (26-01-2022)“…Early detection of kidney disease is of vital importance due to its current prevalence worldwide. Fluorescence imaging, especially in the second near‐infrared…”
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Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging
Published in Current opinion in chemical biology (01-06-2024)“…In vivo luminescence imaging in the second near-infrared window (NIR-II, 1000–2000 nm) is a potent technique for observing deep-tissue life activities,…”
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Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging
Published in Nature nanotechnology (01-10-2023)“…Optical imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) holds great promise for non-invasive in vivo detection. However, real-time dynamic…”
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NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring
Published in Nano letters (26-01-2022)“…In situ monitoring of tissue regeneration progression is of primary importance to basic medical research and clinical transformation. Despite significant…”
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Molecular-Based FRET Nanosensor with Dynamic Ratiometric NIR-IIb Fluorescence for Real-Time In Vivo Imaging and Sensing
Published in Nano letters (24-05-2023)“…Real-time fluorescence sensing can provide insight into biodynamics. However, few fluorescent tools are available to overcome the tissue scattering and…”
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