Search Results - "Wang, Sanyi"

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity by Szczepankiewicz, Bruce G, Kosogof, Christi, Nelson, Lissa T. J, Liu, Gang, Liu, Bo, Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Liu, Mei, Gum, Rebecca J, Haasch, Deanna L, Wang, Sanyi, Clampit, Jill E, Johnson, Eric F, Lubben, Thomas H, Stashko, Michael A, Olejniczak, Edward T, Sun, Chaohong, Dorwin, Sarah A, Haskins, Kristi, Abad-Zapatero, Cele, Fry, Elizabeth H, Hutchins, Charles W, Sham, Hing L, Rondinone, Cristina M, Trevillyan, James M

“…The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to…”
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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors by Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Szczepankiewicz, Bruce G, Liu, Mei, Kosogof, Christi, Liu, Bo, Nelson, Lissa T. J, Johnson, Eric F, Wang, Sanyi, Pederson, Terry, Gum, Rebecca J, Clampit, Jill E, Haasch, Deanna L, Abad-Zapatero, Cele, Fry, Elizabeth H, Rondinone, Cristina, Trevillyan, James M, Sham, Hing L, Liu, Gang

“…C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may…”
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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies by Liu, Mei, Wang, Sanyi, Clampit, Jill E., Gum, Rebecca J., Haasch, Deanna L., Rondinone, Cristina M., Trevillyan, James M., Abad-Zapatero, Cele, Fry, Elizabeth H., Sham, Hing L., Liu, Gang

“…A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with…”
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Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens by Ma, Zhenkun, Clark, Richard F, Brazzale, Antony, Wang, Sanyi, Rupp, Michael J, Li, Leping, Griesgraber, George, Zhang, Suoming, Yong, Hong, Phan, Ly Tam, Nemoto, Peter A, Chu, Daniel T. W, Plattner, Jacob J, Zhang, Xiaolin, Zhong, Ping, Cao, Zhensheng, Nilius, Angela M, Shortridge, Virginia D, Flamm, Robert, Mitten, Michael, Meulbroek, Jon, Ewing, Patty, Alder, Jeff, Or, Yat Sun

“…A novel series of erythromycin derivatives has been discovered with potent activity against key respiratory pathogens, including those resistant to…”
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Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond by Liu, Gang, Zhao, Hongyu, Liu, Bo, Xin, Zhili, Liu, Mei, Kosogof, Christi, Szczepankiewicz, Bruce G., Wang, Sanyi, Clampit, Jill E., Gum, Rebecca J., Haasch, Deanna L., Trevillyan, James M., Sham, Hing L.

“…The structure–activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand…”
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Design, Synthesis, and Antimicrobial Activity of 6-O-Substituted Ketolides Active against Resistant Respiratory Tract Pathogens by Or, Yat Sun, Clark, Richard F, Wang, Sanyi, Chu, Daniel T. W, Nilius, Angela M, Flamm, Robert K, Mitten, Michael, Ewing, Patty, Alder, Jeff, Ma, Zhenkun

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Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors by Liu, Mei, Xin, Zhili, Clampit, Jill E., Wang, Sanyi, Gum, Rebecca J., Haasch, Deanna L., Trevillyan, James M., Abad-Zapatero, Cele, Fry, Elizabeth H., Sham, Hing L., Liu, Gang

“…This paper describes a novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors. These compounds were…”
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Understanding Asphaltene Dispersants for Paraffinic Solvent-Based Bitumen Froth Treatment by Feng, Xianhua, Wang, Sanyi

“…Asphaltene dispersants are used in the paraffinic solvent-based bitumen froth treatment process to increase the fluidity of underflow that is made of…”
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Synthesis and Antimicrobial Activity of 4H-4-Oxoquinolizine Derivatives:  Consequences of Structural Modification at the C-8 Position by Ma, Zhenkun, Chu, Daniel T. W, Cooper, Curt S, Li, Qun, Fung, Anthony K. L, Wang, Sanyi, Shen, Linus L, Flamm, Robert K, Nilius, Angela M, Alder, Jeffery D, Meulbroek, Jonathan A, Or, Yat Sun

“…The antibacterial 4H-4-oxoquinolizines were introduced recently to overcome bacterial resistance to fluoroquinolones. They exhibit potent antibacterial…”
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Deposition of Fine Particles in Packed Beds at Hydrotreating Conditions:  Role of Surface Chemistry by Wang, Sanyi, Chung, Keng H, Masliyah, Jacob H, Gray, Murray R

“…Accumulation of fine particles by packed-bed catalytic reactors causes increased pressure drop, sometimes causing premature shut down. Deposition in a reactor,…”
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Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants by Clark, Richard F., Wang, Sanyi, Ma, Zhenkun, Weitzberg, Moshe, Motter, Christopher, Tufano, Michael, Wagner, Rolf, Gu, Yu-Gui, Dandliker, Peter J., Lerner, Claude G., Chovan, Linda E., Cai, Yingna, Black-Schaefer, Candace L., Lynch, Linda, Kalvin, Douglas, Nilius, Angela M., Pratt, Steve D., Soni, Niru, Zhang, Tianyuan, Zhang, Xiaolin, Beutel, Bruce A.

“…Graphic Structure–activity relationships for a recently discovered novel ribosome inhibitor (NRI) class of antibacterials were investigated. Preliminary…”
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Toluene-insoluble fraction from thermal cracking of Athabasca gas oil: formation of a liquid-in-oil emulsion that wets hydrophobic dispersed solids by Wang, Sanyi, Chung, Keng, Masliyah, Jacob H, Gray, Murray R

“…The formation of a toluene-insoluble (TI) fraction and its interaction with fine solids was studied by heating coker gas oil from Athabasca bitumen in a…”
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Understanding Asphaltene Dispersants for Paraffinic Solvent-Based Bitumen Froth Treatment by XIANHUA FENG, SANYI WANG

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Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives by CLARK, R. F, ZHENKUN MA, YAT SUN OR, SANYI WANG, GRIESGRABER, G, TUFANO, M, HONG YONG, LEPING LI, XIAOLIN ZHANG, NILIUS, A. M, CHU, D. T. W

“…A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues…”
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Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases by Comess, Kenneth M, Sun, Chaohong, Abad-Zapatero, Cele, Goedken, Eric R, Gum, Rebecca J, Borhani, David W, Argiriadi, Maria, Groebe, Duncan R, Jia, Yong, Clampit, Jill E, Haasch, Deanna L, Smith, Harriet T, Wang, Sanyi, Song, Danying, Coen, Michael L, Cloutier, Timothy E, Tang, Hua, Cheng, Xueheng, Quinn, Christopher, Liu, Bo, Xin, Zhili, Liu, Gang, Fry, Elizabeth H, Stoll, Vincent, Ng, Teresa I, Banach, David, Marcotte, Doug, Burns, David J, Calderwood, David J, Hajduk, Philip J

“…Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market. Protein kinase inhibition…”
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A localf-x Cadzow method for noise reduction of seismic data obtained in complex formations by Yuan Sanyi Wang Shangxu

“…A noise-reduction method with sliding called the local f-x Cadzow noise-reduction method, windows in the frequency-space （f-x） domain, is presented in this…”
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Effects of Chemical Application on Antifouling in Steam-Assisted Gravity Drainage Operations by Wang, Sanyi, Axcell, Eric, Bosch, Ron, Little, Virgil

“…The fouling behavior of water streams in steam-assisted gravity drainage (SAGD) operations can be affected by chemical selection, including a reverse emulsion…”
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Breaking Water-in-Bitumen Emulsions using Polyoxyalkylated DETA Demulsifier by Xu, Yuming, Wu, Jiangying, Dabros, Tadek, Hamza, Hassan, Wang, Sanyi, Bidal, Marianne, Venter, Johann, Tran, Tom

“…Adding demulsifier is currently the most widely used method for breaking water‐in‐oil emulsions. Experimental demulsifiers based on DETA with various PO and EO…”
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A Luciferase Assay to Assess JNK1 Activation by Stashko, Michael, Lubben, Thomas, Clampit, Jill, Wang, Sanyi, Sun, Chaohong, Serby, Michael, Liu, Bo, Xin, Zhili, Liu, Gang, Trevillyan, James

“…Activation of JNK1 has been associated with the development of insulin resistance in Type‐2 diabetes. We describe an assay to measure inhibitors of JNK1…”
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Chemistry of deposition of fine particles in catalytic hydrotreaters by Wang, Sanyi

“…This thesis, consisting of three related sections, focuses on the role of chemistry in particle deposition under controlled hydrodynamic conditions. (1)…”
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