Search Results - "Wang, Ruduan"

Evaluation of STK17B as a cancer immunotherapy target utilizing highly potent and selective small molecule inhibitors by Scheuplein, Felix, Renner, Florian, Campbell, John E., Campbell, Robert, De Savi, Chris, Eckmann, Jan, Fischer, Holger, Ge, Jie, Green, Luke, Jakob, Peter, Kim, Joseph L., Kinkema, Caitlin, McGinn, Katie, Medina, Ricardo, Müller, Annemarie, Perez, Nisha, Perola, Emanuele, Timsit, Yoav, Traore, Tary, Hopfer, Ulrike, Tyanova, Stefka, Tzouros, Manuel, Wang, Ruduan, Woessner, Richard, Dorsch, Marion, Bischoff, James R.

“…Introduction The serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to…”
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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response by McClure, Kim F, Darout, Etzer, Guimarães, Cristiano R. W, DeNinno, Michael P, Mascitti, Vincent, Munchhof, Michael J, Robinson, Ralph P, Kohrt, Jeffrey, Harris, Anthony R, Moore, Dianna E, Li, Bryan, Samp, Lacey, Lefker, Bruce A, Futatsugi, Kentaro, Kung, Daniel, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Salter, Eben, Hornby, Sam, Kalgutkar, Amit S, Chen, Yue

“…The synthesis and properties of the bridged piperidine (oxaazabicyclo) compounds 8, 9, and 11 are described. A conformational analysis of these structures is…”
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Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119 by Darout, Etzer, Robinson, Ralph P, McClure, Kim F, Corbett, Matthew, Li, Bryan, Shavnya, Andrei, Andrews, Melissa P, Jones, Christopher S, Li, Qifang, Minich, Martha L, Mascitti, Vincent, Guimarães, Cristiano R. W, Munchhof, Michael J, Bahnck, Kevin B, Cai, Cuiman, Price, David A, Liras, Spiros, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Bagdasarian, Victoria, Sobota, Colleen P, Hornby, Sam, Masterson, Victoria M, Joseph, Reena M, Kalgutkar, Amit S, Chen, Yue

“…A series of GPR119 agonists based on a 2,6-diazatricyclo[3.3.1.1∼3,7∼]decane ring system is described. Also provided is a detailed account of the development…”
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Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells by Russell, J H, Wang, R

“…Antigen receptor-directed suicide plays an important role in the elimination of potentially autoaggressive immature T cells during thymic differentiation. Here…”
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IL‐12 enhances IL‐2 function by inducing CD25 expression through a p38 mitogen‐activated protein kinase pathway by Nguyen, Thang, Wang, Ruduan, Russell, John H.

“…We previously showed that an IL‐2 mutant, Q126D, could induce T cells to proliferate to the same extent as wild‐type IL‐2 but was unable to sensitize T cells…”
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Defective Apoptosis in Lymphocytes and the Role of IL-2 in Autoimmune Hematologic Cytopenias by Shenoy, Shalini, Mohanakumar, T., Chatila, Talal, Tersak, Jean, Duffy, Brian, Wang, Ruduan, Thilenius, Anja R.B., Russell, John H.

“…Fas-mediated signaling is important for lymphocyte elimination. We investigated lymphocytes for Fas-signaling defects in 20 pediatric patients with chronic…”
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Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir by Zhang, Xun, Wang, Ruduan, Piotrowski, Mary, Zhang, Hui, Leach, Karen L.

“…•Major kidney transporters are down-regulated in kidney cell models.•IC50 from cytotoxicity assays differ from intrinsic cytotoxicity due to…”
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An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva by Davis, Alison J, Brooijmans, Natasja, Brubaker, Jason D, Stevison, Faith, LaBranche, Timothy P, Albayya, Faris, Fleming, Paul, Hodous, Brian L, Kim, Joseph L, Kim, Sean, Lobbardi, Riadh, Palmer, Michael, Sheets, Michael P, Vassiliadis, John, Wang, Ruduan, Williams, Brett D, Wilson, Douglas, Xu, Lan, Zhu, Xing Julia, Bouchard, Keith, Hunter, Jeffrey W, Graul, Chris, Greenblatt, Elliot, Hussein, Amira, Lyon, Morgan, Russo, Joelle, Stewart, Rachel, Dorsch, Marion, Guzi, Timothy J, Kadambi, Vivek, Lengauer, Christoph, Garner, Andrew P

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease driven by gain-of-function variants in activin receptor-like kinase 2 (ALK2), the most…”
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Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers by Choi, Yoon J., Wenglowsky, Steve, Brown, Victoria, Bifulco, Neil, Choi, Yeon S., Guo, Jian, Hatlen, Megan, Kim, Joseph, LaBranche, Tim, Lobbardi, Riadh, Perola, Emanuele, Rozsahegyi, Emily, Maynard, Michelle, Ramsden, Phil, Silva, Grace, Stevison, Faith, Vargas, Richard, Wang, Ruduan, Wilson, Doug, Woessner, Rich, Zhang, Dean, Meissner, Rob, Hoeflich, Klaus, Dorsch, Marion

“…Abstract Background: Cyclin dependent kinases (CDK) comprise a family of proteins which are activated upon cyclin binding to promote cell cycle progression…”
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Abstract 2306: BLU-222, an investigational, potent, and selective CDK2 inhibitor, demonstrated robust antitumor activity in CCNE1 -amplified ovarian cancer models by Brown, Victoria, Ramsden, Phil, House, Nealia, Vargas, Richard, Guo, Jian, Wang, Ruduan, Lobbardi, Riadh, Chen, Maxine, Wilson, Douglas, Kim, Joseph, Bifulco, Neil, Maynard, Michelle, Perola, Emanuele, Zhang, Dean, Wenglowsky, Steve, Choi, Yoon Jong

“…Abstract Background: Cyclin-dependent kinases (CDK) are a class of enzymes that, along with their regulatory cyclin binding partners, drive cell cycle…”
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Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor by McClure, Kim F., Jackson, Margaret, Cameron, Kimberly O., Kung, Daniel W., Perry, David A., Orr, Suvi T.M., Zhang, Yingxin, Kohrt, Jeffrey, Tu, Meihua, Gao, Hua, Fernando, Dilinie, Jones, Ryan, Erasga, Noe, Wang, Guoqiang, Polivkova, Jana, Jiao, Wenhua, Swartz, Roger, Ueno, Hirokazu, Bhattacharya, Samit K., Stock, Ingrid A., Varma, Sam, Bagdasarian, Victoria, Perez, Sylvie, Kelly-Sullivan, Dawn, Wang, Ruduan, Kong, Jimmy, Cornelius, Peter, Michael, Laura, Lee, Eunsun, Janssen, Ann, Steyn, Stefanus J., Lapham, Kimberly, Goosen, Theunis

“…The optimization for selectivity and central receptor occupancy for a series of spirocyclic azetidine–piperidine inverse agonists of the ghrelin receptor is…”
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Identification and characterization of a leptin-responsive neuroblastoma cell line by Wang, Ruduan, Swick, Andrew G.

“…The adipocyte-derived hormone leptin plays a critical role in a variety of physiological and pathological actions. As such the determination of leptin signal…”
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Design, synthesis, and pharmacology of fluorescently labeled analogs of serotonin: application to screening of the 5-HT2C receptor by Cornelius, Peter, Lee, Eunsun, Lin, Wen, Wang, Ruduan, Werner, Wendy, Brown, Janice A, Stuhmeier, Frank, Boyd, James G, McClure, Kim

“…Novel fluorescent derivatives of serotonin have been synthesized and used as tracers for the development of a 5-HT2C fluorescence polarization assay. Serotonin…”
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Separation of CD4+ functional responses by peptide dose in Th1 and Th2 subsets expressing the same transgenic antigen receptor by Wang, R, Abrams, S I, Loh, D Y, Hsieh, C S, Murphy, K M, Russell, J H

“…CD4+ T cells from alpha beta-TCR transgenic mice were used to explore the effect of antigen dose on various functional activities. This transgenic system…”
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Mature T Cells of Autoimmune lpr/lpr Mice have a Defect in Antigen- Stimulated Suicide by Russell, John H., Rush, Brian, Weaver, Casey, Wang, Ruduan

“…Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells…”
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Induction of sensitivity to activation-induced death in primary CD4+ cells: a role for interleukin-2 in the negative regulation of responses by mature CD4+ T cells by Wang, R, Rogers, A M, Rush, B J, Russell, J H

“…We examine the requirements for converting naive, mature CD4+ cells from an activation-induced death (AID)-resistant to a -sensitive phenotype. Priming for…”
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CD95-dependent bystander lysis caused by CD4+ T helper 1 effectors by Wang, R, Rogers, AM, Ratliff, TL, Russell, JH

“…CD95-dependent lysis of target cells by CD4+ cells raises important questions of specificity and its potential role in inflammation. Much of what we know about…”
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Partial signaling by cytokines: Cytokine regulation of cell cycle and Fas-dependent, activation-induced death in CD4 super(+) subsets by Wang, Ruduan, Ciardelli, T L, Russell, J H

“…Fas-dependent, activation-induced death (AID) of T cells has been implicated in the regulation of peripheral T cell populations. We have previously reported…”
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Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen- presenting cell [published erratum appears in J Immunol 1993 Jun 15;150(12):5732] by Wang, R, Murphy, KM, Loh, DY, Weaver, C, Russell, JH

“…Stimulation of the TCR of activated, mature T cells by an APC produces a spectrum of functional responses. Most of those responses positively promote immunity…”
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Partial Signaling by Cytokines: Cytokine Regulation of Cell Cycle and Fas-Dependent, Activation-Induced Death in CD4+Subsets by Wang, Ruduan, Ciardelli, Thomas L., Russell, John H.

“…Fas-dependent, activation-induced death (AID) of T cells has been implicated in the regulation of peripheral T cell populations. We have previously reported…”
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