Search Results - "Wang, Pilin"

Nomogram for predicting axillary lymph node pathological response in node-positive breast cancer patients after neoadjuvant chemotherapy by Wang, Wenyan, Wang, Xin, Liu, Jiaqi, Zhu, Qiang, Wang, Xiang, Wang, Pilin

“…Pathological complete response (pCR) of axillary lymph nodes (ALNs) is frequently achieved in patients with clinically node-positive breast cancer after…”
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Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade by Zhang, Fei, Wei, Hudie, Wang, Xiaoxiao, Bai, Yu, Wang, Pilin, Wu, Jiawei, Jiang, Xiaoyong, Wang, Yugang, Cai, Haiyan, Xu, Ting, Zhou, Aiwu

“…The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we…”
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miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase by Zhao, Meng, Sun, Baisheng, Wang, Yan, Qu, Gengbao, Yang, Hua, Wang, Pilin

“…Olaparib has been used in the treatment of triple-negative breast cancer (TNBC) with BRCA mutations. In the present study, we demonstrated the effect of…”
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The Identification of Gene Expression Profiles Associated with Granulomatous Mastitis by Zhu, Qiang, Wang, Lin, Wang, Pilin

“…Background: Granulomatous mastitis (GM) is a rare chronic inflammatory disease of the breast. The current therapeutic effects of the antibiotic therapy and…”
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Monitoring the Response of PD-L1 Expression to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Nonsmall-Cell Lung Cancer Xenografts by Immuno-PET Imaging by Li, Dan, Zou, Sijuan, Cheng, Siyuan, Song, Shuang, Wang, Pilin, Zhu, Xiaohua

“…Accumulating evidence has suggested that the tumor microenvironment of nonsmall-cell lung cancer (NSCLC) may be impacted by chemotherapy, radiotherapy, or…”
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Abstract 3022: Using translational tumor growth inhibition modeling approach and population PK analysis to predict efficacious doses for KN026, a HER2 bispecific antibody by Ji, Dongmei, Xiong, Yuan, Yang, Jing, Wang, Pilin, Wang, Jiarong, Yang, Fei, Xu, Junfang

“…Background: KN026 is a bispecific antibody simultaneously targeting the extracellular domains II and IV of the human HER2. It blocks both ligand-dependent and…”
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JSKN003, A NOVEL BIPARATOPIC ANTI-HER2 ANTIBODY-DRUG CONJUGATE, EXHIBITS POTENT ANTITUMOR EFFICACY by Wang, Pilin, Guo, Kangping, Peng, Jianjian, Sun, Jie, Xu, Ting

“…In human advanced solid tumors, expression of HER2 protein has been reported in various tumor tissues and a variety of cultured tumor cell lines including…”
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Structural basis of a novel heterodimeric Fc for bispecific antibody production by Wei, Hudie, Cai, Haiyan, Jin, Yuhao, Wang, Pilin, Zhang, Qingqing, Lin, Yihui, Wang, Weixiao, Cheng, Jinke, Zeng, Naiyan, Xu, Ting, Zhou, Aiwu

“…Bispecific antibodies provide an efficient tool for combinational clinical therapy. Here we have engineered a heterodimeric Fc for bispecific antibodies…”
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Identification of key genes in HER2-positive breast cancer with brain metastasis via bioinformatics methods by Yang, Ziguo, Sun, Rencheng, Qu, Gengbao, Wang, Feng, Yin, Ziyi, Zhang, Tie, Wang, Pilin, Li, Shaoxiang, Lin, Shuye

“…Brain metastasis (BM) represents one of the most common advanced disease states in breast cancer (BC), especially in human epidermal growth factor receptor 2…”
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Abstract PS1-31: Nomogram for predicting axillary lymph node pathological response in node-positive breast cancer patients after neoadjuvant chemotherapy by Wang, Xin, Wang, Wenyan, Liu, Jiaxiang, Meng, Xiangzhi, Liu, Jiaqi, Guo, Changyuan, Song, Ying, Cui, Ningyi, Li, Qiao, Xing, Zeyu, Wang, Jie, Zhang, Menglu, Feng, Kexin, Wang, Pilin, Wang, Xiang

“…Background: Pathological complete response (pCR) of axillary lymph nodes (ALNs) is frequently achieved in patients with clinically node-positive breast cancer…”
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Abstract LB021: KN-052, a novel PDL1/OX40 bispecific antibody, exhibits potent antitumor efficacy by Xu, Ting, Wang, Pilin, Fu, Yang-Xin, Guo, Kangping, Peng, Jianjian

“…KN052 is a recombinant PDL1/OX40 bispecific antibody which can block PDL1 and PD1/CD80 pathway and active the OX40 signal pathway at the same time. Inhibited…”
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Immuno-PET Imaging of 89Zr Labeled Anti-PD-L1 Domain Antibody by Li, Dan, Cheng, Siyuan, Zou, Sijuan, Zhu, Dongling, Zhu, Tinghui, Wang, Pilin, Zhu, Xiaohua

“…Recently, various immuno-PET tracers based on monoclonal antibodies (mAbs), engineered scaffold proteins, and peptides were developed to target either…”
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Immuno-PET Imaging of 89 Zr Labeled Anti-PD-L1 Domain Antibody by Li, Dan, Cheng, Siyuan, Zou, Sijuan, Zhu, Dongling, Zhu, Tinghui, Wang, Pilin, Zhu, Xiaohua

“…Recently, various immuno-PET tracers based on monoclonal antibodies (mAbs), engineered scaffold proteins, and peptides were developed to target either…”
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CG001, a C3b-targeted complement inhibitor, blocks 3 complement pathways: development and preclinical evaluation by Li, Ling, Ding, Peipei, Dong, Yanrong, Shen, Shupei, Lv, Xinyue, Yu, Jie, Li, Luying, Chen, Jianfeng, Wang, Pilin, Han, Bing, Xu, Ting, Hu, Weiguo

“…•The human-derived and antibody-like C3b-targeted fusion protein CG001 may simultaneously and effectively block 3 complement pathways.•CG001 holds high…”
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Phase I safety and pharmacokinetic study of KN035, the first subcutaneously administered, novel fusion anti-PD-L1 antibody in Japanese patients with advanced solid tumors by Shimizu, Toshio, Nakajima, Takako Eguchi, Lu, Ni, Xue, Shilin, Xu, Wenlian, Fu, Meng, Cao, Walt, Lu, Haolan, Liu, David, Dong, RuiPing, Wang, Xiaoxiao, Wang, Pilin, Zhu, Danming, Xu, Ting, Gong, John

“…Abstract only 2609 Background: KN035 is a novel fusion protein of humanized anti-PD-L1 single domain antibody and human IgG1 Fc, formulated for subcutaneous…”
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Phase I study of KN035, the first subcutaneously administered, novel fusion anti-PD-L1 antibody in patients with advanced solid tumors in China by Xu, Jian-Ming, Qin, Shukui, Zhang, Yun, Zhang, Yaoyue, Jia, Ru, Liu, Rongrui, Zhang, Gairong, Zhao, Chuanhua, Lu, Ni, Liu, Huilong, Xu, Wenlian, Fu, Meng, Cao, Walt, Lu, Haolan, Liu, David, Dong, Ruiping, Wang, Xiaoxiao, Wang, Pilin, Xu, Ting, Gong, John

“…Abstract only 2608 Background: KN035 is a novel fusion protein of humanized anti-PD-L1 single domain antibody and human IgG1 Fc fragment, formulated for…”
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ADAM29 Expression in Human Breast Cancer and its Effects on Breast Cancer Cells In Vitro by Zhao, Meng, Jia, Wang, Jiang, Wen G, Wang, Pilin, DU, Guifang, Cheng, Shan, Song, Maomin

“…A Disintegrin and Metalloprotease Domain 29 (ADAM29) is involved in many important physiological processes. Recent studies have demonstrated that ADAM29 is a…”
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A phase I, open, multiple dose, dose escalation and expansion study to evaluate the safety, tolerability, and pharmacokinetics of KN035 (anti-PD-L1 antibody) administered in subcutaneous injection as a single agent to Chinese subjects with advanced solid tumors by Xu, Jianming, Qin, Shukui, Zhang, Yun, Zhang, Yaoyue, Jia, Ru, Liu, Rongrui, Wang, Yan, Zhang, Gairong, Zhao, Chuanhua, Lu, Ni, Ma, Xiaoyu, He, Yue, Yuan, Liwei, Lin, Yihui, Xu, Wenlian, Wang, Xiaoxiao, Wang, Pilin, Xu, Ting, Dong, RuiPing, Gong, John

“…Abstract only…”
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Development and characterization of a novel long-acting recombinant follicle stimulating hormone agonist by fusing Fc to an FSH-β subunit by Zhang, Yin-Li, Guo, Kang-Ping, Ji, Shu-Yan, Liu, Xiao-Man, Wang, Pilin, Wu, Jie, Gao, Li, Jiang, Tian-Qi, Xu, Ting, Fan, Heng-Yu

“…Abstract STUDY QUESTION Does a novel long-acting recombinant human FSH, KN015, a heterodimer composed of FSHα and FSHβ-Fc/Fc, offer a potential FSH…”
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Ileal interposition reduces blood glucose levels and decreases insulin resistance in a type 2 diabetes mellitus animal model by up-regulating glucagon-like peptide-1 and its receptor by Sun, Xu, Zheng, Meizhu, Song, Maomin, Bai, Rixing, Cheng, Shi, Xing, Ying, Yuan, Huisheng, Wang, Pilin

“…This study is to explore the possible mechanism of ileal interposition (IT) treatment of glycemic control of the type 2 diabetes mellitus (T2DM) by…”
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