Search Results - "Wang, Panxia"

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3 by Lu, Jing, Xu, Suowen, Huo, Yuqing, Sun, Duanping, Hu, Yuehuai, Wang, Junjian, Zhang, Xiaolei, Wang, Panxia, Li, Zhuoming, Liang, Mengya, Wu, Zhongkai, Liu, Peiqing

“…Sorting nexins (SNXs), the retromer-associated cargo binding proteins, have emerged as critical regulators of the trafficking of proteins involved in the…”
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Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway by Fang, Xiuli, Liu, Yajun, Lu, Jing, Hong, Huiqi, Yuan, Jing, Zhang, Yuhong, Wang, Panxia, Liu, Peiqing, Ye, Jiantao

“…Protocatechuic aldehyde (PCA) is a natural compound found in the Chinese herb Salvia miltiorrhiza . It has been shown to possess multiple biological activities…”
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SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction by He, Ping, Li, Zhuoming, Yue, Zhongbao, Gao, Hui, Feng, Guoshuai, Wang, Panxia, Huang, Yi, Luo, Wenwei, Hong, Huiqi, Liang, Liying, Chen, Shaorui, Liu, Peiqing

“…Silent mating type information regulation 2 homolog 3 (SIRT3) is a major protective mediator that ameliorates oxidative stress and mitochondrial dysfunction,…”
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Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression by Wang, Panxia, Wang, Minghui, Hu, Yuehuai, Chen, Jianxing, Cao, Yanjun, Liu, Cui, Wu, Zhongkai, Shen, Juan, Lu, Jing, Liu, Peiqing

“…As an effective anticancer drug, the clinical limitation of doxorubicin (Dox) is the time- and dose-dependent cardiotoxicity. Yes-associated protein 1 (YAP1)…”
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Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress by Jia, Zhenmao, Wang, Panxia, Xu, Yuansheng, Feng, Guodong, Wang, Quan, He, Xiangjun, Song, Yan, Liu, Peiqing, Chen, Jianwen

“…Background: Ulcerative colitis (UC) is one type of inflammatory bowel disease, characterized by inflammation with infiltration and activation of macrophages in…”
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SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy by Li, Zhenzhen, Zhang, Xiaoying, Guo, Zhen, Zhong, Yao, Wang, Panxia, Li, Jingyan, Li, Zhuoming, Liu, Peiqing

“…NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac…”
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PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression by Cai, Sidong, Liu, Rong, Wang, Panxia, Li, Jingyan, Xie, Tingting, Wang, Minghui, Cao, Yanjun, Li, Zhuoming, Liu, Peiqing

“…The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In…”
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Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis by Yu, Wenjing, Hu, Yuehuai, Liu, Zhiping, Guo, Kaiteng, Ma, Dinghu, Peng, Mingxia, Wang, Yuemei, Zhang, Jing, Zhang, Xiaolei, Wang, Panxia, Zhang, Jiguo, Liu, Peiqing, Lu, Jing

“…The clinical utilization of doxorubicin (Dox) in various malignancies is restrained by its major adverse effect: irreversible cardiomyopathy. Extensive studies…”
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Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation by Lu, Jing, Li, Jingyan, Hu, Yuehuai, Guo, Zhen, Sun, Duanping, Wang, Panxia, Guo, Kaiteng, Duan, Dayue Darrel, Gao, Si, Jiang, Jianmin, Wang, Junjian, Liu, Peiqing

“…The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an…”
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Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage by Ye, Zesen, Wang, Panxia, Feng, Guodong, Wang, Quan, Liu, Cui, Lu, Jing, Chen, Jianwen, Liu, Peiqing

“…Acute lung injury (ALI) is a life-threatening inflammatory disease without effective therapeutic regimen. Macrophage polarization plays a key role in the…”
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PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy by Li, Jingyan, Gao, Hui, Huang, Junying, Wang, Panxia, Huang, Yi, Luo, Wenwei, Zhang, Xiaoying, Shen, Peiye, You, Jia, Cai, Sidong, Li, Zhuoming, Liu, Peiqing

“…This study was aimed to investigate the crosstalk between protein kinase C ζ (PKCζ) and signal transducer and activator of transcription 3 (STAT3) in…”
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Targeting castration-resistant prostate cancer with a novel RORγ antagonist elaiophylin by Zheng, Jianwei, Wang, Junfeng, Wang, Qian, Zou, Hongye, Wang, Hong, Zhang, Zhenhua, Chen, Jianghe, Wang, Qianqian, Wang, Panxia, Zhao, Yueshan, Lu, Jing, Zhang, Xiaolei, Xiang, Songtao, Wang, Haibin, Lei, Jinping, Chen, Hong-Wu, Liu, Peiqing, Liu, Yonghong, Han, Fanghai, Wang, Junjian

“…Prostate cancer (PCa) patients who progress to metastatic castration-resistant PCa (mCRPC) mostly have poor outcomes due to the lack of effective therapies…”
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Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression by Wang, Panxia, Lan, Rui, Guo, Zhen, Cai, Sidong, Wang, Junjian, Wang, Quan, Li, Zeyu, Li, Zhenzhen, Wang, Qianqian, Li, Jingyan, Wu, Zhongkai, Lu, Jing, Liu, Peiqing

“…Jumonji domain-containing 3 (JMJD3) protein, a histone demethylase protein, specifically catalyzes the demethylation of H3K27 (H3K27me3) and regulates gene…”
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Electrochemical biosensor based on gold nanoflowers-encapsulated magnetic metal-organic framework nanozymes for drug evaluation with in-situ monitoring of H2O2 released from H9C2 cardiac cells by Lu, Jing, Hu, Yuehuai, Wang, Panxia, Liu, Peiqing, Chen, Zuanguang, Sun, Duanping

“…[Display omitted] •An electrochemical sensor was proposed for detecting H2O2 released from living cells.•MoS2 nanosheets support magnetic metal…”
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SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function by Wang, Panxia, Wang, Luping, Lu, Jing, Hu, Yuehuai, Wang, Qianqian, Li, Zhenzhen, Cai, Sidong, Liang, Liying, Guo, Kaiteng, Xie, Jiyan, Wang, Junjian, Lan, Rui, Shen, Juan, Liu, Peiqing

“…The clinical application of doxorubicin (Dox) in cancer therapy is limited by its serious cardiotoxicity. Our previous studies and others have recognized that…”
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Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/β-catenin signaling pathway by Liang, Liying, Tu, Yalin, Lu, Jing, Wang, Panxia, Guo, Zhen, Wang, Qianqian, Guo, Kaiteng, Lan, Rui, Li, Hong, Liu, Peiqing

“…The cancer clinical therapy of doxorubicin (Dox) treatment is limited by its life-threatening cardiotoxic effects. Dickkopf-1 (Dkk1), the founding and…”
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PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy by Wang, Luping, Li, Zhuoming, Tan, Yinzi, Li, Qian, Yang, Hanwei, Wang, Panxia, Lu, Jing, Liu, Peiqing

“…The activation of signal transducer and activator of transcription 3 (STAT3) positively regulates myocardial hypertrophy, and its transcriptional activity is…”
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Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway by Duan, Yongzhen, Huang, Peixian, Sun, Lu, Wang, Panxia, Cai, Yi, Shi, Tingting, Li, Yuliang, Zhou, Yuhua, Yu, Shanshan

“…The clinical application of doxorubicin (DOX) was limited by the serious cardiotoxicity. The traditional Chinese medicine Andrographis paniculata and its…”
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JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing β-MHC expression by Guo, Zhen, Lu, Jing, Li, Jingyan, Wang, Panxia, Li, Zhenzhen, Zhong, Yao, Guo, Kaiteng, Wang, Junjian, Ye, Jiantao, Liu, Peiqing

“…Jumonji domain-containing protein D3 (JMJD3), a histone 3 lysine 27 (H3K27) demethylase, has been extensively studied for their participation in development,…”
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Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation by Hu, Yuehuai, Zheng, Yongjia, Liu, Cui, You, Yuyu, Wu, Ying, Wang, Panxia, Wu, Yiyang, Ba, Hongjun, Lu, Jing, Yuan, Yanqiu, Liu, Peiqing, Mao, Yang

“…Lysine acetylation is a conserved post-translational modification involved in energy metabolism in mitochondria and heart function. This study investigates the…”
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