Search Results - "Wang, Nuofan"
-
1
HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors
Published in Cell death & disease (27-07-2020)“…The pentose phosphate pathway (PPP) plays a critical role in maintaining cellular redox homeostasis in tumor cells and macromolecule biosynthesis. Upregulation…”
Get full text
Journal Article -
2
METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer
Published in Frontiers in oncology (28-04-2022)“…The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear…”
Get full text
Journal Article -
3
N 6 -methyladenosine modification regulates imatinib resistance of gastrointestinal stromal tumor by enhancing the expression of multidrug transporter MRP1
Published in Cancer letters (01-04-2022)“…N -methyladenosine (m A) is a frequently occurring mRNA modification, which regulates mRNA stability, splicing, and translation. However, its role in drug…”
Get full text
Journal Article -
4
Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction
Published in Cell reports (Cambridge) (15-02-2022)“…Tumor physical microenvironment contributes greatly to the response of tumor cells. However, the mechanism of how extracellular substrate rigidity remodels…”
Get full text
Journal Article -
5
N6-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors
Published in Cell death and differentiation (01-02-2023)“…Secondary resistance to imatinib (IM) represents a major challenge for therapy of gastrointestinal stromal tumors (GISTs). Aberrations in oncogenic pathways,…”
Get full text
Journal Article -
6
Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours
Published in Oncogene (16-03-2023)“…Imatinib is a tyrosine kinase inhibitor that is widely used to combat gastrointestinal stromal tumours (GISTs). However, secondary resistance to imatinib is an…”
Get full text
Journal Article -
7
N6-methyladenosine modification regulates imatinib resistance of gastrointestinal stromal tumor by enhancing the expression of multidrug transporter MRP1
Published in Cancer letters (01-04-2022)“…N6-methyladenosine (m6A) is a frequently occurring mRNA modification, which regulates mRNA stability, splicing, and translation. However, its role in drug…”
Get full text
Journal Article -
8
Circulating tumor cells in whole process management of gastrointestinal stromal tumor in a real-life setting
Published in Saudi journal of gastroenterology (01-05-2020)“…Background/Aim: Liquid biopsy is changing the diagnosis and treatment strategies of various neoplasms. However, the circulating tumor cells (CTCs) of…”
Get full text
Journal Article -
9
HMGA1 Regulates the Stem Cell-Like Properties of Circulating Tumor Cells from GIST Patients via Wnt/β-Catenin Pathway
Published in OncoTargets and therapy (01-01-2020)“…Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the digestive system. Circulating tumor cells (CTCs) have been proven to be critical in the…”
Get full text
Journal Article -
10
N 6 -methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors
Published in Cell death and differentiation (01-02-2023)“…Secondary resistance to imatinib (IM) represents a major challenge for therapy of gastrointestinal stromal tumors (GISTs). Aberrations in oncogenic pathways,…”
Get full text
Journal Article