Search Results - "Wang, Nasi"
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Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry
Published in Bioorganic & medicinal chemistry (01-11-2016)“…[Display omitted] The free fatty acid receptor 1 (FFA1/GPR40) is a novel antidiabetic target based on particular mechanism in enhancing glucose-stimulated…”
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Discovery of the Environmental Factors Affecting Urban Dwellers' Mental Health: A Data-Driven Approach
Published in International journal of environmental research and public health (05-11-2020)“…Mental health is the foundation of health and happiness as well as the basis for an individual's meaningful life. The environmental and social health of a city…”
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Design, synthesis and structure–activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker
Published in Bioorganic & medicinal chemistry (15-04-2017)“…[Display omitted] The free fatty acid receptor 1 (FFA1/GPR40) has attracted extensive attention as a novel antidiabetic target. Aiming to explore the chemical…”
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Improving metabolic stability with deuterium: The discovery of HWL‐066, a potent and long‐acting free fatty acid receptor 1 agonists
Published in Chemical biology & drug design (01-08-2018)“…The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancing of glucose‐stimulated insulin secretion. The FFA1 agonist GW9508…”
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Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
Published in Bioorganic & medicinal chemistry (15-02-2018)“…Amining to develop pharmacological and improve aqueous solubility, we have identified series of TRPV1 antagonists bearing phenylquinoline moiety, exemplified…”
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