Search Results - "Wang, Minxian"

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions by Fahed, Akl C., Wang, Minxian, Homburger, Julian R., Patel, Aniruddh P., Bick, Alexander G., Neben, Cynthia L., Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T., Cassa, Christopher A., Lebo, Matthew, Ng, Kenney, Lander, Eric S., Zhou, Alicia Y., Kathiresan, Sekar, Khera, Amit V.

“…Genetic variation can predispose to disease both through (i) monogenic risk variants that disrupt a physiologic pathway with large effect on disease and (ii)…”
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Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy by Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.

“…Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been…”
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Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots by Agrawal, Saaket, Wang, Minxian, Klarqvist, Marcus D. R., Smith, Kirk, Shin, Joseph, Dashti, Hesam, Diamant, Nathaniel, Choi, Seung Hoan, Jurgens, Sean J., Ellinor, Patrick T., Philippakis, Anthony, Claussnitzer, Melina, Ng, Kenney, Udler, Miriam S., Batra, Puneet, Khera, Amit V.

“…For any given level of overall adiposity, individuals vary considerably in fat distribution. The inherited basis of fat distribution in the general population…”
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Editorial: Machine learning-based methods for RNA data analysis-Volume II by Peng, Lihong, Yang, Jialiang, Wang, Minxian, Zhou, Liqian

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Editorial: Machine Learning-Based Methods for RNA Data Analysis by Peng, Lihong, Yang, Jialiang, Wang, Minxian, Zhou, Liqian

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Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients by Pan, Weili, Ren, Yongkui, Yang, Fan, Wang, Minxian, Li, Xinsheng, Yin, Da

“…Hypertension is a leading risk of coronary artery disease (CAD). Triglyceride glucose index (TyG) is a surrogate of insulin resistance (IR). Few studies…”
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Epidemiological characteristics of alcohol-related liver disease in China: a systematic review and meta-analysis by Tang, Zongzhe, Ding, Yajie, Zhang, Wei, Zhang, Ru, Zhang, Liuxin, Wang, Minxian, Wang, Min, Chen, Yue, Wang, Jie

“…This meta-analysis aimed to explore the epidemiological characteristics of alcohol-related liver disease (ALD) in China. Studies published between January 2000…”
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The predictive value of coronary artery calcium score combined with traditional risk factors for obstructive coronary heart disease in young people by Sun, Ronglin, Pan, Weili, Wang, Minxian, Chen, Xiaohong, Yin, Da, Ren, Yongkui

“…This study attempts to compare the predictive effects of several prediction models on obstructive coronary artery disease (OCAD) in young patients (30-50 years…”
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Predictive value of machine learning algorithm of coronary artery calcium score and clinical factors for obstructive coronary artery disease in hypertensive patients by Wang, Minxian, Sun, Mengting, Yu, Yao, Li, Xinsheng, Ren, Yongkui, Yin, Da

“…Abstract Background The addition of coronary artery calcium score (CACS) to prediction models has been verified to improve performance. Machine learning (ML)…”
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The Idesia polycarpa genome provides insights into its evolution and oil biosynthesis by Zuo, Yi, Liu, Hongbing, Li, Bin, Zhao, Hang, Li, Xiuli, Chen, Jiating, Wang, Lu, Zheng, Qingbo, He, Yuqing, Zhang, Jiashuo, Wang, Minxian, Liang, Chengzhi, Wang, Lei

“…The deciduous tree Idesia polycarpa can provide premium edible oil with high polyunsaturated fatty acid contents. Here, we generate its high-quality reference…”
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South Asian medical cohorts reveal strong founder effects and high rates of homozygosity by Wall, Jeffrey D., Sathirapongsasuti, J. Fah, Gupta, Ravi, Rasheed, Asif, Venkatesan, Radha, Belsare, Saurabh, Menon, Ramesh, Phalke, Sameer, Mittal, Anuradha, Fang, John, Tanneeru, Deepak, Deshmukh, Manjari, Bassi, Akshi, Robinson, Jacqueline, Chaudhary, Ruchi, Murugan, Sakthivel, ul-Asar, Zameer, Saleem, Imran, Ishtiaq, Unzila, Fatima, Areej, Sheikh, Saqib Shafi, Hameed, Shahid, Ishaq, Mohammad, Rasheed, Syed Zahed, Memon, Fazal-ur-Rehman, Jalal, Anjum, Abbas, Shahid, Frossard, Philippe, Fuchsberger, Christian, Forer, Lukas, Schoenherr, Sebastian, Bei, Qixin, Bhangale, Tushar, Tom, Jennifer, Gadde, Santosh Gopi Krishna, B V, Priya, Naik, Naveen Kumar, Wang, Minxian, Kwok, Pui-Yan, Khera, Amit V., Lakshmi, B. R., Butterworth, Adam S., Chowdhury, Rajiv, Danesh, John, di Angelantonio, Emanuele, Naheed, Aliya, Goyal, Vinay, Kandadai, Rukmini M., Kumar, Hrishikesh, Borgohain, Rupam, Mukherjee, Adreesh, Wadia, Pettarusp M., Yadav, Ravi, Desai, Soaham, Kumar, Niraj, Biswas, Atanu, Pal, Pramod Kumar, Muthane, Uday B., Das, Shymal K., Ramprasad, Vedam L., Kukkle, Prashanth L., Seshagiri, Somasekar, Kathiresan, Sekar, Ghosh, Arkasubhra, Mohan, V., Saleheen, Danish, Stawiski, Eric W., Peterson, Andrew S.

“…The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored…”
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De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis by Weng, Patricia L., Majmundar, Amar J., Khan, Kamal, Lim, Tze Y., Shril, Shirlee, Jin, Gina, Musgrove, John, Wang, Minxian, Ahram, Dina F., Aggarwal, Vimla S., Bier, Louise E., Heinzen, Erin L., Onuchic-Whitford, Ana C., Mann, Nina, Buerger, Florian, Schneider, Ronen, Deutsch, Konstantin, Kitzler, Thomas M., Klämbt, Verena, Kolb, Amy, Mao, Youying, Moufawad El Achkar, Christelle, Mitrotti, Adele, Martino, Jeremiah, Beck, Bodo B., Altmüller, Janine, Benz, Marcus R., Yano, Shoji, Mikati, Mohamad A., Gunduz, Talha, Cope, Heidi, Shashi, Vandana, Trachtman, Howard, Bodria, Monica, Caridi, Gianluca, Pisani, Isabella, Fiaccadori, Enrico, AbuMaziad, Asmaa S., Martinez-Agosto, Julian A., Yadin, Ora, Zuckerman, Jonathan, Kim, Arang, John-Kroegel, Ulrike, Tyndall, Amanda V., Parboosingh, Jillian S., Innes, A. Micheil, Bierzynska, Agnieszka, Koziell, Ania B., Muorah, Mordi, Saleem, Moin A., Hoefele, Julia, Riedhammer, Korbinian M., Gharavi, Ali G., Jobanputra, Vaidehi, Pierce-Hoffman, Emma, Seaby, Eleanor G., O’Donnell-Luria, Anne, Rehm, Heidi L., Mane, Shrikant, D’Agati, Vivette D., Pollak, Martin R., Ghiggeri, Gian Marco, Lifton, Richard P., Goldstein, David B., Davis, Erica E., Hildebrandt, Friedhelm, Sanna-Cherchi, Simone

“…Focal segmental glomerulosclerosis (FSGS) is the main pathology underlying steroid-resistant nephrotic syndrome (SRNS) and a leading cause of chronic kidney…”
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Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study by Wang, Minxian, Zhang, Ru, Wang, Min, Zhang, Liuxin, Ding, Yajie, Tang, Zongzhe, Wang, Hongliang, Zhang, Wei, Chen, Yue, Wang, Jie

“…Background Previous studies have highlighted the important role of vitamin D and calcium pathway genes in immune modulation, cell differentiation and…”
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Vitamin D Level and Vitamin D Receptor Genetic Variation Were Involved in the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study by Zhang, Ru, Wang, Minxian, Wang, Min, Zhang, Liuxin, Ding, Yajie, Tang, Zongzhe, Fu, Zuqiang, Fan, Haozhi, Zhang, Wei, Wang, Jie

“…It has been demonstrated that vitamin D receptor ( ), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver…”
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Machine learning enables new insights into genetic contributions to liver fat accumulation by Haas, Mary E., Pirruccello, James P., Friedman, Samuel N., Wang, Minxian, Emdin, Connor A., Ajmera, Veeral H., Simon, Tracey G., Homburger, Julian R., Guo, Xiuqing, Budoff, Matthew, Corey, Kathleen E., Zhou, Alicia Y., Philippakis, Anthony, Ellinor, Patrick T., Loomba, Rohit, Batra, Puneet, Khera, Amit V.

“…Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease and cardiometabolic diseases but often remains undiagnosed in…”
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Corrigendum: Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study by Wang, Minxian, Zhang, Ru, Wang, Min, Zhang, Liuxin, Ding, Yajie, Tang, Zongzhe, Wang, Hongliang, Zhang, Wei, Chen, Yue, Wang, Jie

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Evaluating the Potential of T Cell Receptor Repertoires in Predicting the Prognosis of Resectable Non-Small Cell Lung Cancers by Song, Zhengbo, Chen, Xiangbin, Shi, Yi, Huang, Rongfang, Wang, Wenxian, Zhu, Kunshou, Lin, Shaofeng, Wang, Minxian, Tian, Geng, Yang, Jialiang, Chen, Gang

“…For resectable cancer patients, a method that could precisely predict the risk of postoperative recurrence would be crucial for guiding adjuvant treatment…”
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A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study by Wang, Min, Wang, Minxian, Zhang, Ru, Zhang, Liuxin, Ding, Yajie, Tang, Zongzhe, Fan, Haozhi, Wang, Hongliang, Zhang, Wei, Chen, Yue, Wang, Jie

“…Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of…”
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Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study by Pérez-Sáez, María José, Uffing, Audrey, Leon, Juliette, Murakami, Naoka, Watanabe, Andreia, Borges, Thiago J., Sabbisetti, Venkata S., Cureton, Pamela, Kenyon, Victoria, Keating, Leigh, Yee, Karen, Fernandes Satiro, Carla Aline, Serena, Gloria, Hildebrandt, Friedhelm, Riella, Cristian V., Libermann, Towia A., Wang, Minxian, Pascual, Julio, Bonventre, Joseph V., Cravedi, Paolo, Fasano, Alessio, Riella, Leonardo V.

“…Kidney disease affects 10% of the world population and is associated with increased mortality. Steroid-resistant nephrotic syndrome (SRNS) is a leading cause…”
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Combining serum uric acid and fatty liver index to improve prediction quality of nonalcoholic fatty liver disease by Ding, Yajie, Tang, Zongzhe, Wang, Minxian, Wang, Min, Zhang, Ru, Zhang, Liuxin, Zhang, Mengting, Guan, Qing, Wang, Jie

“…Background: The significant association between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD) is well documented. In this report, we…”
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