Search Results - "Wang, Lexun"

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  1. 1

    M2b Macrophages Regulate Cardiac Fibroblast Activation and Alleviate Cardiac Fibrosis After Reperfusion Injury by Yue, Yuan, Huang, Suiqing, Wang, Lexun, Wu, Zixuan, Liang, Mengya, Li, Huayang, Lv, Linhua, Li, Wei, Wu, Zhongkai

    Published in Circulation Journal (25-03-2020)
    “…Background:Macrophages play an important role in the development of cardiac fibrosis. However, the roles of different macrophage subtypes in cardiac fibroblast…”
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  2. 2

    The markers to delineate different phenotypes of macrophages related to metabolic disorders by Wei, Quxing, Deng, Yanyue, Yang, Qianqian, Zhan, Angyu, Wang, Lexun

    Published in Frontiers in immunology (03-02-2023)
    “…Macrophages have a wide variety of roles in physiological and pathological conditions, making them promising diagnostic and therapeutic targets in diseases,…”
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  3. 3

    M2b macrophages reduce early reperfusion injury after myocardial ischemia in mice: A predominant role of inhibiting apoptosis via A20 by Yue, Yuan, Yang, Xiao, Feng, Kangni, Wang, Lexun, Hou, Jian, Mei, Bo, Qin, Han, Liang, Mengya, Chen, Guangxian, Wu, Zhongkai

    Published in International journal of cardiology (15-10-2017)
    “…Monocytes or macrophages have been assessed as potential therapeutics to ameliorate myocardial ischemic diseases, but the results have been controversial. As…”
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  4. 4

    MicroRNA-24-3p alleviates cardiac fibrosis by suppressing cardiac fibroblasts mitophagy via downregulating PHB2 by Zhang, Yue, Wang, Zhiying, Lan, Dingming, Zhao, Jingjing, Wang, Lexun, Shao, Xiaoqi, Wang, Dongwei, Wu, Kaili, Sun, Mengxian, Huang, Xueying, Yan, Meiling, Liang, Haihai, Rong, Xianglu, Diao, Hongtao, Guo, Jiao

    Published in Pharmacological research (01-03-2022)
    “…Cardiac fibrosis is a pathological process of multiple cardiovascular diseases, which may lead to heart failure. Studies have shown that microRNAs (miRNAs)…”
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  5. 5

    Tetrahydropalmatine attenuates liver fibrosis by suppressing endoplasmic reticulum stress in hepatic stellate cells by Xuan, Yuanyuan, Chen, Shiyun, Ding, Xin, Wang, Lexun, Li, Shengwen, Yang, Guizhi, Lan, Tian

    Published in Chinese medical journal (30-12-2021)
    “…Quantitative real-time PCR (qPCR) assays showed that hepatic mRNA levels of profibrotic genes, such as α-SMA, Collagen I, platelet-derived growth factor,…”
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  6. 6

    The traditional Chinese medicine formula Fufang-Zhenzhu-Tiaozhi protects myocardia from injury in diabetic minipigs with coronary heart disease by Song, Lixia, Zhang, Dongxing, Guo, Caijuan, Gu, Zhanhui, Wang, Lexun, Yao, Yu Si, Wang, Hong, Zeng, Zhihuan, Wang, Weixuan, Yang, Yiqi, Bei, Weijian, Rong, Xianglu, Guo, Jiao

    Published in Biomedicine & pharmacotherapy (01-05-2021)
    “…Diabetes mellitus (DM) is a major risk factor for coronary heart disease (CHD). Previous research has reported that the Fufang-Zhenzhu-Tiaozhi (FTZ) formula…”
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  7. 7

    Ginsenoside Rb1 ameliorates the abnormal hepatic glucose metabolism by activating STAT3 in T2DM mice by Wang, Weixuan, Zhan, Wenjing, Liang, Mingjie, Huang, Yuanfeng, Liu, Yuan, Wang, Lexun, Bei, Weijian, Guo, Jiao

    Published in Journal of functional foods (01-05-2023)
    “…[Display omitted] •Ginsenoside Rb1 improves type 2 diabetes mellitus.•Rb1 ameliorates the abnormal hepatic glucose metabolism in T2DM mice.•Rb1 promotes…”
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  8. 8

    FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway by Wang, Hong, Huang, Minyi, Bei, Weijian, Yang, Yiqi, Song, Lixia, Zhang, Dongxing, Zhan, Wenjing, Zhang, Yuzhen, Chen, Xu, Wang, Weixuan, Wang, Lexun, Guo, Jiao

    Published in Biomedicine & pharmacotherapy (01-06-2021)
    “…Fufang Zhenzhu Tiaozhi formula (FTZ), a preparation of Chinese herbal medicine, has various pharmacological properties, such as hypoglycemic, hypolipidemic,…”
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    FTZ protects against cardiac hypertrophy and oxidative injury via microRNA-214 / SIRT3 signaling pathway by Zhang, Yue, Sun, Mengxian, Wang, Dongwei, Hu, Yaju, Wang, Ruonan, Diao, Hongtao, Shao, Xiaoqi, Li, Yun, Li, Xu, Leng, Mingyang, Wang, Lexun, Yan, Meiling, Rong, Xianglu, Guo, Jiao

    Published in Biomedicine & pharmacotherapy (01-04-2022)
    “…Despite the fact that the initial hypertrophic response to ventricular pressure overload is thought to be compensatory, prolonged stress often leads to heart…”
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    Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics by Huang, Yuanfeng, Liang, Mingjie, Liao, Yiwen, Ji, Zirui, Lin, Wanfen, Pu, Xiangjin, Wang, Lexun, Wang, Weixuan

    Published in Metabolites (20-09-2024)
    “…This study focused on exploring the effects of SW033291, an inhibitor of 15-hydroxyprostaglandin dehydrogenase, on type 2 diabetes mellitus (T2DM) mice from a…”
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  13. 13

    Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate type 2 diabetes by regulating adipoinsular axis in diabetic mice by Xu, Siyuan, Ye, Bixian, Li, Jinlei, Dou, Yonghui, Yu, Yuying, Feng, Yifan, Wang, Lexun, Wan, David Chi-Cheong, Rong, Xianglu

    Published in Frontiers in pharmacology (15-08-2022)
    “…The global morbidity of obesity and type 2 diabetes mellitus (T2DM) has dramatically increased. Insulin resistance is the most important pathogenesis and…”
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  14. 14

    Traditional Chinese Medicine Fufang-Zhenzhu-Tiaozhi capsule prevents renal injury in diabetic minipigs with coronary heart disease by Song, Lixia, Wang, Ke, Yin, Jianying, Yang, Yiqi, Li, Bo, Zhang, Dongxing, Wang, Hong, Wang, Weixuan, Zhan, Wenjing, Guo, Caijuan, Gu, Zhanhui, Wang, Lexun, Zeng, Zhihuan, Bei, Weijian, Rong, Xianglu, Guo, Jiao

    Published in Chinese medicine (30-08-2022)
    “…Abstract Background Renal injury is one of the common microvascular complications of diabetes, known as diabetic kidney disease (DKD) seriously threatening…”
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  15. 15

    CCAAT/Enhancer-Binding Proteins in Fibrosis: Complex Roles Beyond Conventional Understanding by Wang, Lexun, Feng, Jiaojiao, Deng, Yanyue, Yang, Qianqian, Wei, Quxing, Ye, Dewei, Rong, Xianglu, Guo, Jiao

    Published in Research (Washington) (01-01-2022)
    “…CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified transcription factors that contain a highly conserved basic leucine zipper…”
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    Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models by Yang, Xiaoyan, Huang, Shiguang, Chen, Jianping, Song, Ning, Wang, Lexun, Zhang, Zengfang, Deng, Guozhen, Zheng, Huanqin, Zhu, Xing-Quan, Lu, Fangli

    Published in Vaccine (08-01-2010)
    “…Abstract Human vaccines are not available and current anti-toxoplasma treatment is disappointing. To investigate the possible adjuvant effect of aqueous…”
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  18. 18

    Comparison of two serpins of Clonorchis sinensis by bioinformatics, expression, and localization in metacercaria by Yang, Yabo, Hu, Dong, Wang, Lexun, Liang, Chi, Hu, Xuchu, Xu, Jin, Huang, Yan, Yu, Xinbing

    Published in Pathogens and global health (01-06-2014)
    “…Clonorchiasis, which has been an important public health problem in China, is caused by ingestion of raw or undercooked fish contaminated by live metacercaria…”
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  19. 19

    Expression and immune response analysis of Schistosoma japonicum VAL-1, a homologue of vespid venom allergens by Chen, Jingfang, Hu, Xuchu, He, Sijie, Wang, Lexun, Hu, Dong, Wang, Xiaoyun, Zheng, Minghui, Yang, Yabo, Liang, Chi, Xu, Jin, Yu, Xinbing

    Published in Parasitology research (1987) (01-05-2010)
    “…Many parasites such as trematodes and nematodes have been found to express members of a gene family variously termed as venom allergen-like protein (VAL) or…”
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  20. 20

    Molecular cloning and characterization of a novel serpin gene of Clonorchis sinensis, highly expressed in the stage of metacercaria by Yang, Yabo, Hu, Dong, Wang, Lexun, Liang, Chi, Hu, Xuchu, Wang, Xiaoyun, Chen, Jingfang, Xu, Jin, Yu, Xinbing

    Published in Parasitology research (1987) (01-12-2009)
    “…The serpins are a superfamily of proteins (350-500 amino acids in size) that fold into a conserved structure. From about 3,475 unigenes of Clonorchis sinensis…”
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