Search Results - "Wang, Lexun"
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M2b Macrophages Regulate Cardiac Fibroblast Activation and Alleviate Cardiac Fibrosis After Reperfusion Injury
Published in Circulation Journal (25-03-2020)“…Background:Macrophages play an important role in the development of cardiac fibrosis. However, the roles of different macrophage subtypes in cardiac fibroblast…”
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The markers to delineate different phenotypes of macrophages related to metabolic disorders
Published in Frontiers in immunology (03-02-2023)“…Macrophages have a wide variety of roles in physiological and pathological conditions, making them promising diagnostic and therapeutic targets in diseases,…”
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M2b macrophages reduce early reperfusion injury after myocardial ischemia in mice: A predominant role of inhibiting apoptosis via A20
Published in International journal of cardiology (15-10-2017)“…Monocytes or macrophages have been assessed as potential therapeutics to ameliorate myocardial ischemic diseases, but the results have been controversial. As…”
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MicroRNA-24-3p alleviates cardiac fibrosis by suppressing cardiac fibroblasts mitophagy via downregulating PHB2
Published in Pharmacological research (01-03-2022)“…Cardiac fibrosis is a pathological process of multiple cardiovascular diseases, which may lead to heart failure. Studies have shown that microRNAs (miRNAs)…”
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Tetrahydropalmatine attenuates liver fibrosis by suppressing endoplasmic reticulum stress in hepatic stellate cells
Published in Chinese medical journal (30-12-2021)“…Quantitative real-time PCR (qPCR) assays showed that hepatic mRNA levels of profibrotic genes, such as α-SMA, Collagen I, platelet-derived growth factor,…”
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The traditional Chinese medicine formula Fufang-Zhenzhu-Tiaozhi protects myocardia from injury in diabetic minipigs with coronary heart disease
Published in Biomedicine & pharmacotherapy (01-05-2021)“…Diabetes mellitus (DM) is a major risk factor for coronary heart disease (CHD). Previous research has reported that the Fufang-Zhenzhu-Tiaozhi (FTZ) formula…”
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Ginsenoside Rb1 ameliorates the abnormal hepatic glucose metabolism by activating STAT3 in T2DM mice
Published in Journal of functional foods (01-05-2023)“…[Display omitted] •Ginsenoside Rb1 improves type 2 diabetes mellitus.•Rb1 ameliorates the abnormal hepatic glucose metabolism in T2DM mice.•Rb1 promotes…”
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FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway
Published in Biomedicine & pharmacotherapy (01-06-2021)“…Fufang Zhenzhu Tiaozhi formula (FTZ), a preparation of Chinese herbal medicine, has various pharmacological properties, such as hypoglycemic, hypolipidemic,…”
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The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice
Published in Biomedicine & pharmacotherapy (01-08-2023)“…Diabetic cardiomyopathy (DCM) is an important complication leading to the death of patients with diabetes, but there is no effective strategy for clinical…”
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FTZ protects against cardiac hypertrophy and oxidative injury via microRNA-214 / SIRT3 signaling pathway
Published in Biomedicine & pharmacotherapy (01-04-2022)“…Despite the fact that the initial hypertrophic response to ventricular pressure overload is thought to be compensatory, prolonged stress often leads to heart…”
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Chinese medicine Fufang Zhenzhu Tiaozhi capsule ameliorates coronary atherosclerosis in diabetes mellitus-related coronary heart disease minipigs
Published in Biomedicine & pharmacotherapy (01-12-2022)“…Diabetes mellitus-related coronary heart disease (DM-CHD) is the most common cause of death in diabetic patients. Various studies have shown that Chinese…”
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Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics
Published in Metabolites (20-09-2024)“…This study focused on exploring the effects of SW033291, an inhibitor of 15-hydroxyprostaglandin dehydrogenase, on type 2 diabetes mellitus (T2DM) mice from a…”
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Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate type 2 diabetes by regulating adipoinsular axis in diabetic mice
Published in Frontiers in pharmacology (15-08-2022)“…The global morbidity of obesity and type 2 diabetes mellitus (T2DM) has dramatically increased. Insulin resistance is the most important pathogenesis and…”
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Traditional Chinese Medicine Fufang-Zhenzhu-Tiaozhi capsule prevents renal injury in diabetic minipigs with coronary heart disease
Published in Chinese medicine (30-08-2022)“…Abstract Background Renal injury is one of the common microvascular complications of diabetes, known as diabetic kidney disease (DKD) seriously threatening…”
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CCAAT/Enhancer-Binding Proteins in Fibrosis: Complex Roles Beyond Conventional Understanding
Published in Research (Washington) (01-01-2022)“…CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified transcription factors that contain a highly conserved basic leucine zipper…”
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Sequence analysis and molecular characterization of Clonorchis sinensis hexokinase, an unusual trimeric 50-kDa glucose-6-phosphate-sensitive allosteric enzyme
Published in PloS one (18-09-2014)“…Clonorchiasis, which is induced by the infection of Clonorchis sinensis (C. sinensis), is highly associated with cholangiocarcinoma. Because the available…”
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Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models
Published in Vaccine (08-01-2010)“…Abstract Human vaccines are not available and current anti-toxoplasma treatment is disappointing. To investigate the possible adjuvant effect of aqueous…”
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Comparison of two serpins of Clonorchis sinensis by bioinformatics, expression, and localization in metacercaria
Published in Pathogens and global health (01-06-2014)“…Clonorchiasis, which has been an important public health problem in China, is caused by ingestion of raw or undercooked fish contaminated by live metacercaria…”
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Expression and immune response analysis of Schistosoma japonicum VAL-1, a homologue of vespid venom allergens
Published in Parasitology research (1987) (01-05-2010)“…Many parasites such as trematodes and nematodes have been found to express members of a gene family variously termed as venom allergen-like protein (VAL) or…”
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Molecular cloning and characterization of a novel serpin gene of Clonorchis sinensis, highly expressed in the stage of metacercaria
Published in Parasitology research (1987) (01-12-2009)“…The serpins are a superfamily of proteins (350-500 amino acids in size) that fold into a conserved structure. From about 3,475 unigenes of Clonorchis sinensis…”
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