Search Results - "Wang, Kevin KW"

Dual Vulnerability of TDP-43 to Calpain and Caspase-3 Proteolysis after Neurotoxic Conditions and Traumatic Brain Injury by Yang, Zhihui, Lin, Fan, Robertson, Claudia S, Wang, Kevin KW

“…Transactivation response DNA-binding protein 43 (TDP-43) proteinopathy has recently been reported in chronic traumatic encephalopathy, a neurodegenerative…”
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Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype by Sadasivan, Shankar, Zhang, Zhiqun, Larner, Stephen F, Liu, Ming C, Zheng, Wenrong, Kobeissy, Firas H, Hayes, Ronald L, Wang, Kevin K W

“…Autophagy, an intracellular response to stress, is characterized by double membrane cytosolic vesicles called autophagosomes. Prolonged autophagy is known to…”
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Neuroprotection targets after traumatic brain injury by Wang, Kevin K W, Larner, Stephen F, Robinson, Gillian, Hayes, Ronald L

“…The scarcity of pharmacological neuroprotective treatments for traumatic brain injury is a concern being targeted on various fronts. This review examines the…”
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Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker by Yang, Zhihui, Wang, Kevin K.W

“…Highlights • GFAP is tightly regulated at mRNA level and by PTMs. • GFAP plays a critical role in astrogliosis after CNS injury and in neurodegeneration. •…”
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Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting to Emergency Departments with Mild Brain Injury: A Living Systematic Review and Meta-Analysis by Mondello, Stefania, Sorinola, Abayomi, Czeiter, Endre, Vámos, Zoltán, Amrein, Krisztina, Synnot, Anneliese, Donoghue, Emma, Sándor, János, Wang, Kevin K W, Diaz-Arrastia, Ramon, Steyerberg, Ewout W, Menon, David K, Maas, Andrew I R, Buki, Andras

“…Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A…”
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Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury by Manek, Rachna, Moghieb, Ahmed, Yang, Zhihui, Kumar, Dhwani, Kobessiy, Firas, Sarkis, George Anis, Raghavan, Vijaya, Wang, Kevin K.W.

“…Recently, there have been emerging interests in the area of microvesicles and exosome (MV/E) released from brain cells in relation to neurodegenerative…”
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GFAP out-performs S100β in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions by Papa, Linda, Silvestri, Salvatore, Brophy, Gretchen M, Giordano, Philip, Falk, Jay L, Braga, Carolina F, Tan, Ciara N, Ameli, Neema J, Demery, Jason A, Dixit, Neha K, Mendes, Matthew E, Hayes, Ronald L, Wang, Kevin K W, Robertson, Claudia S

“…Both glial fibrillary acidic protein (GFAP) and S100β are found in glial cells and are released into serum following a traumatic brain injury (TBI), however,…”
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A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids by Rubenstein, Richard, Chang, Binggong, Davies, Peter, Wagner, Amy K, Robertson, Claudia S, Wang, Kevin K W

“…Traumatic brain injury (TBI) is a cause of death and disability and can lead to tauopathy-related dementia at an early age. Pathologically, TBI results in…”
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Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein by Diaz-Arrastia, Ramon, Wang, Kevin K W, Papa, Linda, Sorani, Marco D, Yue, John K, Puccio, Ava M, McMahon, Paul J, Inoue, Tomoo, Yuh, Esther L, Lingsma, Hester F, Maas, Andrew I R, Valadka, Alex B, Okonkwo, David O, Manley, Geoffrey T

“…Biomarkers are important for accurate diagnosis of complex disorders such as traumatic brain injury (TBI). For a complex and multifaceted condition such as…”
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Raising the Bar for Traumatic Brain Injury Biomarker Research: Methods Make a Difference by Papa, Linda, Wang, Kevin K W

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Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot study by Tate, Charmaine M, Wang, Kevin K W, Eonta, Stephanie, Zhang, Yang, Carr, Walter, Tortella, Frank C, Hayes, Ronald L, Kamimori, Gary H

“…"Breachers" are a unique military and law enforcement population because they are routinely exposed to low-level blast (LLB) during training and operations…”
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Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy by Kochanek, Patrick M, Bramlett, Helen M, Dixon, C Edward, Shear, Deborah A, Dietrich, W Dalton, Schmid, Kara E, Mondello, Stefania, Wang, Kevin K W, Hayes, Ronald L, Povlishock, John T, Tortella, Frank C

“…Traumatic brain injury (TBI) was the signature injury in both the Iraq and Afghan wars and the magnitude of its importance in the civilian setting is finally…”
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Blood-based diagnostics of traumatic brain injuries by Mondello, Stefania, Muller, Uwe, Jeromin, Andreas, Streeter, Jackson, Hayes, Ronald L, Wang, Kevin K W

“…Traumatic brain injury is a major health and socioeconomic problem that affects all societies. However, traditional approaches to the classification of…”
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Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury by Karlsson, Michael, Yang, Zhihui, Chawla, Sanjeev, Delso, Nile, Pukenas, Bryan, Elmér, Eskil, Hugerth, Matilda, Margulies, Susan S, Ehinger, Johannes, Hansson, Magnus J, Wang, Kevin K W, Kilbaugh, Todd J

“…All phase III trials evaluating medical treatments for traumatic brain injury (TBI), performed to date, have failed. To facilitate future success there is a…”
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Glibenclamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy by Jha, Ruchira M, Mondello, Stefania, Bramlett, Helen M, Dixon, C Edward, Shear, Deborah A, Dietrich, W Dalton, Wang, Kevin K W, Yang, Zhihui, Hayes, Ronald L, Poloyac, Samuel M, Empey, Philip E, Lafrenaye, Audrey D, Yan, Hong Q, Carlson, Shaun W, Povlishock, John T, Gilsdorf, Janice S, Kochanek, Patrick M

“…Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in…”
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Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids by Brophy, Gretchen M, Mondello, Stefania, Papa, Linda, Robicsek, Steven A, Gabrielli, Andrea, Tepas, 3rd, Joseph, Buki, Andras, Robertson, Claudia, Tortella, Frank C, Hayes, Ronald L, Wang, Kevin K W

“…Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been identified as a potential biomarker of traumatic brain injury (TBI). The…”
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Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy by Mondello, Stefania, Shear, Deborah A, Bramlett, Helen M, Dixon, C Edward, Schmid, Kara E, Dietrich, W Dalton, Wang, Kevin K W, Hayes, Ronald L, Glushakova, Olena, Catania, Michael, Richieri, Steven P, Povlishock, John T, Tortella, Frank C, Kochanek, Patrick M

“…Operation Brain Trauma Therapy (OBTT) is a multicenter pre-clinical drug screening consortium testing promising therapies for traumatic brain injury (TBI) in…”
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Calpain in the CNS: from synaptic function to neurotoxicity by Liu, Jing, Liu, Ming Cheng, Wang, Kevin K W

“…The calpains are a class of cellular cysteine proteases that require calcium and are functionally active at neutral pH. Calpain activation can take place in…”
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Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy by Browning, Megan, Shear, Deborah A, Bramlett, Helen M, Dixon, C Edward, Mondello, Stefania, Schmid, Kara E, Poloyac, Samuel M, Dietrich, W Dalton, Hayes, Ronald L, Wang, Kevin K W, Povlishock, John T, Tortella, Frank C, Kochanek, Patrick M

“…Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was…”
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Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator by Czeiter, Endre, Mondello, Stefania, Kovacs, Noemi, Sandor, Janos, Gabrielli, Andrea, Schmid, Kara, Tortella, Frank, Wang, Kevin K W, Hayes, Ronald L, Barzo, Pal, Ezer, Erzsebet, Doczi, Tamas, Buki, Andras

“…Outcome prediction following severe traumatic brain injury (sTBI) is a widely investigated field of research. A major breakthrough is represented by the IMPACT…”
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