Search Results - "Wang, Kangsheng"

Phenotypic Profiling of DPYD Variations Relevant to 5-Fluorouracil Sensitivity Using Real-time Cellular Analysis and In Vitro Measurement of Enzyme Activity by OFFER, Steven M, WEGNER, Natalie J, FOSSUM, Croix, KANGSHENG WANG, DIASIO, Robert B

“…In the 45 years since its development, the pyrimidine analog 5-fluorouracil (5-FU) has become an integral component of many cancer treatments, most notably for…”
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A lightweight method of integrated local load forecasting and control of edge computing in active distribution networks by Wang, Yubo, Zhao, Xingang, Wang, Kangsheng, Chen, He, Wang, Yang, Yu, Hao, Li, Peng

“…The strong resource constraints of edge-computing devices and the dynamic evolution of load characteristics put forward higher requirements for forecasting…”
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Adaptive forecasting of diverse electrical and heating loads in community integrated energy system based on deep transfer learning by Wang, Kangsheng, Yu, Hao, Song, Guanyu, Xu, Jing, Li, Juan, Li, Peng

“…The economic operation and scheduling of community integrated energy system (CIES) depend on accurate day-ahead multi-energy load forecasting. Considering the…”
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A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Two Schedules of Vorinostat in Combination with 5-Fluorouracil and Leucovorin in Patients with Refractory Solid Tumors by FAKIH, Marwan G, FETTERLY, Gerald, EGORIN, Merrill J, MUINDI, Josephia R, ESPINOZA-DELGADO, Igor, ZWIEBEL, James A, LITWIN, Alan, HOLLERAN, Julianne L, KANGSHENG WANG, DIASIO, Robert B

“…We conducted a phase I clinical trial to determine the maximum tolerated dose (MTD) of daily or twice daily vorinostat x 3 days when combined with fixed doses…”
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Profound Dihydropyrimidine Dehydrogenase Deficiency Resulting from a Novel Compound Heterozygote Genotype by Johnson, Martin R, Wang, Kangsheng, Diasio, Robert B

“…A familial approach was used to elucidate the genetic determinants of profound and partial dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2) deficiency in an…”
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Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil by JOHNSON, M. R, HAGEBOUTROS, A, KANGSHENG WANG, HIGH, L, SMITH, J. B, DIASIO, R. B

“…In humans, 80–90% of an administered dose of 5-fluorouracil (5-FU) is degraded by dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2), the initial…”
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Oil prices and systemic financial risk: A complex network analysis by Wang, Kangsheng, Wen, Fenghua, Gong, Xu

“…The risk associated with the dramatic volatility of oil prices has become an important factor affecting the stability of the financial system. Through a…”
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Return spillover across the carbon market and financial markets: A quantile-based approach by Wen, Fenghua, Wang, Kangsheng, Zeng, Aiqing

“…This study examines the dynamic risk contagion between carbon and financial markets in extreme market conditions using a freshly developed methodology for…”
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Activation of Protein Kinase C Induces Nuclear Translocation of RFX1 and Down-regulates c-myc via an Intron 1 X Box in Undifferentiated Leukemia HL-60 Cells by Chen, Lei, Smith, Lucinda, Johnson, Martin R., Wang, Kangsheng, Diasio, Robert B., Smith, Jeffrey Bingham

“…Treatment of human promyelocytic leukemia cells (HL-60) with phorbol 12-myristate 13-acetate (PMA) is known to decrease c-myc mRNA by blocking transcription…”
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Abstract 5451: High-throughput detection of dihydropyrimidine dehydrogenase gene ( DPYD ) variants using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) by Lee, Adam Michael, Moertel, Jessica, Wang, Kangsheng, Diasio, Robert B.

“…Catabolism of fluoropyrimidine drugs such as 5-fluorouracil (5-FU) and its prodrug capecitabine depends on an exclusive enzymatic step, dihydropyrimidine…”
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Quantitation of Dihydropyrimidine Dehydrogenase Expression by Real-Time Reverse Transcription Polymerase Chain Reaction by Johnson, Martin R., Wang, Kangsheng, Smith, Jeffrey B., Heslin, Martin J., Diasio, Robert B.

“…Several recent studies have reported a correlation between intratumor dihydropyrimidine dehydrogenase (DPD) messenger RNA (mRNA) levels and sensitivity to…”
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CSCE: Boosting LLM Reasoning by Simultaneous Enhancing of Casual Significance and Consistency by Wang, Kangsheng, Zhang, Xiao, Guo, Zizheng, Hu, Tianyu, Ma, Huimin

“…Chain-based reasoning methods like chain of thought (CoT) play a rising role in solving reasoning tasks for large language models (LLMs). However, the causal…”
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CreDes: Causal Reasoning Enhancement and Dual-End Searching for Solving Long-Range Reasoning Problems using LLMs by Wang, Kangsheng, Zhang, Xiao, Liu, Hao, Han, Songde, Ma, Huimin, Hu, Tianyu

“…Large language models (LLMs) have demonstrated limitations in handling combinatorial optimization problems involving long-range reasoning, partially due to…”
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Synergistic Spotting and Recognition of Micro-Expression via Temporal State Transition by Zou, Bochao, Guo, Zizheng, Qin, Wenfeng, Li, Xin, Wang, Kangsheng, Ma, Huimin

“…Micro-expressions are involuntary facial movements that cannot be consciously controlled, conveying subtle cues with substantial real-world applications. The…”
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Multiple Gene Expression Analyses in Paraffin-Embedded Tissues by TaqMan Low-Density Array: Application to Hedgehog and Wnt Pathway Analysis in Ovarian Endometrioid Adenocarcinoma by Steg, Adam, Wang, Wenquan, Blanquicett, Carmelo, Grunda, Jessica M, Eltoum, Isam A, Wang, Kangsheng, Buchsbaum, Donald J, Vickers, Selwyn M, Russo, Suzanne, Diasio, Robert B, Frost, Andra R, LoBuglio, Al F, Grizzle, William E, Johnson, Martin R

“…Recent studies have shown the hedgehog and Wnt families of signaling proteins to be associated with tumor initiation, growth, and survival. However, these…”
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Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression by Zhang, Xue, Soong, Richie, Wang, Kangsheng, Li, Lin, Davie, James R, Guarcello, Vincenzo, Diasio, Robert B

“…Dihydropyrimidine dehydrogenase (DPD) is one of the factors that determine the efficacy and toxicity of 5-fluorouracil. Variations in DPD activity may result…”
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Multiple Gene Expression Analyses in Paraffin-Embedded Tissues by TaqMan Low-Density Array by Steg, Adam, Wang, Wenquan, Blanquicett, Carmelo, Grunda, Jessica M., Eltoum, Isam A., Wang, Kangsheng, Buchsbaum, Donald J., Vickers, Selwyn M., Russo, Suzanne, Diasio, Robert B., Frost, Andra R., LoBuglio, Al F., Grizzle, William E., Johnson, Martin R.

“…Recent studies have shown the hedgehog and Wnt families of signaling proteins to be associated with tumor initiation, growth, and survival. However, these…”
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