Search Results - "Wang, Jin Lei"

Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities, and Perspectives by Wang, Jin-Lei, Zhang, Nian-Zhang, Li, Ting-Ting, He, Jun-Jun, Elsheikha, Hany M., Zhu, Xing-Quan

“…Important progress has been made in understanding how immunity is elicited against Toxoplasma gondii – a complex pathogen with multiple mechanisms of immune…”
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The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii by Wang, Jin-Lei, Li, Ting-Ting, Elsheikha, Hany M., Liang, Qin-Li, Zhang, Zhi-Wei, Wang, Meng, Sibley, L. David, Zhu, Xing-Quan

“…Phenotypic switching between tachyzoite and bradyzoite is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite…”
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Electropolymerization of dopamine for surface modification of complex-shaped cardiovascular stents by Wang, Jin-lei, Li, Bo-chao, Li, Zi-jun, Ren, Ke-feng, Jin, Lie-jiang, Zhang, Shi-miao, Chang, Hao, Sun, Yi-xin, Ji, Jian

“…Abstract Inspired by the adhesion strategy of marine mussels, self-polymerization of dopamine under alkaline condition has been proven to be a simple and…”
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Immunization with Toxoplasma gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice by Wang, Jin-Lei, Elsheikha, Hany M, Zhu, Wei-Ning, Chen, Kai, Li, Ting-Ting, Yue, Dong-Mei, Zhang, Xiao-Xuan, Huang, Si-Yang, Zhu, Xing-Quan

“…Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a Δ mutant by disrupting the…”
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The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence by Liang, Qin-Li, Nie, Lan-Bi, Elsheikha, Hany M, Li, Ting-Ting, Sun, Li-Xiu, Zhang, Zhi-Wei, Wang, Meng, Fu, Bao-Quan, Zhu, Xing-Quan, Wang, Jin-Lei

“…Protein phosphatases are post-translational regulators of Toxoplasma gondii proliferation, tachyzoite-bradyzoite differentiation and pathogenesis. Here, we…”
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Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection by Wang, Jin‐Lei, Bai, Meng‐Jie, Elsheikha, Hany M., Liang, Qin‐Li, Li, Ting‐Ting, Cao, Xue‐Zhen, Zhu, Xing‐Quan

“…Dense granule protein 12 (GRA12) is implicated in a range of processes related to the establishment of Toxoplasma gondii infection, such as the formation of…”
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Two Tales of Cytauxzoon felis Infections in Domestic Cats by Wang, Jin-Lei, Li, Ting-Ting, Liu, Guo-Hua, Zhu, Xing-Quan, Yao, Chaoqun

“…Cytauxzoonosis is an emerging infectious disease that affects wild felids as well as the domestic cat; it is caused by the apicomplexan protozoan parasites…”
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The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony by Wang, Jin-Lei, Li, Ting-Ting, Zhang, Nian-Zhang, Wang, Meng, Sun, Li-Xiu, Zhang, Zhi-Wei, Fu, Bao-Quan, Elsheikha, Hany M., Zhu, Xing-Quan

“…Sexual development in Toxoplasma gondii is a multistep process that culminates in the production of oocysts, constituting approximately 50% of human…”
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A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii by Zheng, Xiao-Nan, Sun, Li-Xiu, Elsheikha, Hany M, Li, Ting-Ting, Gao, Jin, Wu, Xiao-Jing, Zhang, Zhi-Wei, Wang, Meng, Fu, Bao-Quan, Zhu, Xing-Quan, Wang, Jin-Lei

“…Pathogenicity of the zoonotic pathogen Toxoplasma gondii largely depends on the secretion of effector proteins into the extracellular milieu and host cell…”
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The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii by Li, Ting‐Ting, Zhao, Dan‐Yu, Liang, Qin‐Li, Elsheikha, Hany M., Wang, Meng, Sun, Li‐Xiu, Zhang, Zhi‐Wei, Chen, Xiao‐Qing, Zhu, Xing‐Quan, Wang, Jin‐Lei

“…Glutaredoxins (Grxs) are ubiquitous antioxidant proteins involved in many molecular processes to protect cells against oxidative damage. Here, we study the…”
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Surface-mediated transfection of a pDNA vector encoding short hairpin RNA to downregulate TGF-β1 expression for the prevention of in-stent restenosis by Zhang, He, Ren, Ke-feng, Chang, Hao, Wang, Jin-lei, Ji, Jian

“…Abstract In-stent restenosis is one of the most serious modes of failure of cardiovascular stent implant. Although drug-eluting stents have been proven to…”
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Chitosan/poly (vinyl pyrollidone) coatings improve the antibacterial properties of poly(ethylene terephthalate) by Wang, Bai-liang, Wang, Jin-lei, Li, Dan-dan, Ren, Ke-feng, Ji, Jian

“…► CHI/PVP coatings were coated on pretreated PET to enhance the binding capacity of the coatings. ► CHI/PVP coatings have favorable bactericidal activity…”
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Rapid and Visual Detection of Trichinella Spp. Using a Lateral Flow Strip-Based Recombinase Polymerase Amplification (LF-RPA) Assay by Li, Ting-Ting, Wang, Jin-Lei, Zhang, Nian-Zhang, Li, Wen-Hui, Yan, Hong-Bin, Li, Li, Jia, Wan-Zhong, Fu, Bao-Quan

“…spp., are amongst the most widespread parasitic nematodes, primarily live in the muscles of a wide range of vertebrate animals and humans. Human infection…”
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Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii -Induced Transcriptional Landscapes by He, Jun-Jun, Ma, Jun, Wang, Jin-Lei, Zhang, Fu-Kai, Li, Jie-Xi, Zhai, Bin-Tao, Wang, Ze-Xiang, Elsheikha, Hany M, Zhu, Xing-Quan

“…We characterized the porcine tissue transcriptional landscapes that follow infection. RNAs were isolated from liver, spleen, cerebral cortex, lung, and…”
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Direct Adhesion of Endothelial Cells to Bioinspired Poly(dopamine) Coating Through Endogenous Fibronectin and Integrin α5β1 by Wang, Jin-Lei, Ren, Ke-Feng, Chang, Hao, Jia, Fan, Li, Bo-Chao, Ji, Ying, Ji, Jian

“…Mussel‐inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In…”
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Construction of Degradable Multilayer Films for Enhanced Antibacterial Properties by Wang, Bai-liang, Ren, Ke-feng, Chang, Hao, Wang, Jin-lei, Ji, Jian

“…Infections associated with medical devices have become a major concern. The adhesion of bacteria to the devices’ surfaces during the initial 24 h is believed…”
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Trx4, a novel thioredoxin protein, is important for Toxoplasma gondii fitness by Zhang, Zhi-Wei, Wang, Meng, Sun, Li-Xiu, Elsheikha, Hany M, Lei, Cheng-Lin, Wang, Jin-Lei, Fu, Bao-Quan, Luo, Jian-Xun, Zhu, Xing-Quan, Li, Ting-Ting

“…To successfully replicate within the host cell, Toxoplasma gondii employs several mechanisms to overcome the host cell defenses and mitigate the harmful…”
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Effect of deletion of gra17 and gra23 genes on the growth, virulence, and immunogenicity of type II Toxoplasma gondii by Li, Ting-Ting, Wang, Jin-Lei, Liang, Qin-Li, Sun, Li-Xiu, Zhang, Hai-Sheng, Zhang, Zhi-Wei, Zhu, Xing-Quan, Elsheikha, Hany M.

“…The protozoan parasite Toxoplasma gondii secretes a number of dense granule proteins (GRAs) from the dense granule organelle to manipulate the host cell. Two…”
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Immunization With a DNA Vaccine Cocktail Encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 Genes Protects Mice Against Chronic Toxoplasmosis by Zhang, Nian-Zhang, Gao, Qi, Wang, Meng, Elsheikha, Hany M, Wang, Bo, Wang, Jin-Lei, Zhang, Fu-Kai, Hu, Ling-Ying, Zhu, Xing-Quan

“…Toxoplasmosis is a zoonotic disease caused by the intracellular protozoan ; and a major source of infection in humans is ingestion of tissue cysts. Ultimately,…”
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Functional Characterization of Dense Granule Proteins in Toxoplasma gondii RH Strain Using CRISPR-Cas9 System by Bai, Meng-Jie, Wang, Jin-Lei, Elsheikha, Hany M, Liang, Qin-Li, Chen, Kai, Nie, Lan-Bi, Zhu, Xing-Quan

“…Infection with the apicomplexan protozoan parasite is an ongoing public health problem. The parasite's ability to invade and replicate within the host cell is…”
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