Search Results - "Wang, Jean C.Y."

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy by Larochelle, André, Vormoor, Josef, Hanenberg, Helmut, Wang, Jean C.Y, Bhatia, Mickie, Lapidot, Tsvee, Moritz, Thomas, Murdoch, Barbara, Xiao, Xiang Li, Kato, Ikunoshin, WIlliams, David A, Dick, John E

“…The development of stem-cell gene therapy is hindered by the absence of repopulation assays for primitive human hematopoietic cells. Current methods of gene…”
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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia by Shlush, Liran I., Zandi, Sasan, Mitchell, Amanda, Chen, Weihsu Claire, Brandwein, Joseph M., Gupta, Vikas, Kennedy, James A., Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., McLeod, Jessica L., Doedens, Monica, Medeiros, Jessie J. F., Marke, Rene, Kim, Hyeoung Joon, Lee, Kwon, McPherson, John D., Hudson, Thomas J., Pan-Leukemia Gene Panel Consortium, The HALT, Brown, Andrew M. K., Yousif, Fouad, Trinh, Quang M., Stein, Lincoln D., Minden, Mark D., Wang, Jean C. Y., Dick, John E.

“…In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly…”
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Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells by Notta, Faiyaz, Mullighan, Charles G., Wang, Jean C. Y., Poeppl, Armando, Doulatov, Sergei, Phillips, Letha A., Ma, Jing, Minden, Mark D., Downing, James R., Dick, John E.

“…Many tumours are composed of genetically diverse cells; however, little is known about how diversity evolves or the impact that diversity has on functional…”
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia by Škrtić, Marko, Sriskanthadevan, Shrivani, Jhas, Bozhena, Gebbia, Marinella, Wang, Xiaoming, Wang, Zezhou, Hurren, Rose, Jitkova, Yulia, Gronda, Marcela, Maclean, Neil, Lai, Courteney K., Eberhard, Yanina, Bartoszko, Justyna, Spagnuolo, Paul, Rutledge, Angela C., Datti, Alessandro, Ketela, Troy, Moffat, Jason, Robinson, Brian H., Cameron, Jessie H., Wrana, Jeffery, Eaves, Connie J., Minden, Mark D., Wang, Jean C.Y., Dick, John E., Humphries, Keith, Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.

“…To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial…”
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Age-related clonal hematopoiesis: implications for hematopoietic stem cell transplantation by Abelson, Sagi, Wang, Jean C.Y

“…PURPOSE OF REVIEWOver the past decade, advances in hematopoietic stem cell transplantation (HSCT) have enabled older individuals to undergo the procedure as…”
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells by Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.

“…To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from…”
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Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells by Nieborowska-Skorska, Margaret, Sullivan, Katherine, Dasgupta, Yashodhara, Podszywalow-Bartnicka, Paulina, Hoser, Grazyna, Maifrede, Silvia, Martinez, Esteban, Di Marcantonio, Daniela, Bolton-Gillespie, Elisabeth, Cramer-Morales, Kimberly, Lee, Jaewong, Li, Min, Slupianek, Artur, Gritsyuk, Daniel, Cerny-Reiterer, Sabine, Seferynska, Ilona, Stoklosa, Tomasz, Bullinger, Lars, Zhao, Huaqing, Gorbunova, Vera, Piwocka, Katarzyna, Valent, Peter, Civin, Curt I, Muschen, Markus, Dick, John E, Wang, Jean Cy, Bhatia, Smita, Bhatia, Ravi, Eppert, Kolja, Minden, Mark D, Sykes, Stephen M, Skorski, Tomasz

“…Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous…”
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Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells by Mortin-Toth, Steven M, Takenaka, Katsuto, Gan, Olga I, Danska, Jayne S, Prasolava, Tatiana K, Dick, John E, Wang, Jean C Y, Khalouei, Sam

“…Graft failure in the transplantation of hematopoietic stem cells occurs despite donor-host genetic identity of human leukocyte antigens, suggesting that…”
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Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors by Sukhai, Mahadeo A, Prabha, Swayam, Hurren, Rose, Rutledge, Angela C, Lee, Anna Y, Sriskanthadevan, Shrivani, Sun, Hong, Wang, Xiaoming, Skrtic, Marko, Seneviratne, Ayesh, Cusimano, Maria, Jhas, Bozhena, Gronda, Marcela, MacLean, Neil, Cho, Eunice E, Spagnuolo, Paul A, Sharmeen, Sumaiya, Gebbia, Marinella, Urbanus, Malene, Eppert, Kolja, Dissanayake, Dilan, Jonet, Alexia, Dassonville-Klimpt, Alexandra, Li, Xiaoming, Datti, Alessandro, Ohashi, Pamela S, Wrana, Jeff, Rogers, Ian, Sonnet, Pascal, Ellis, William Y, Corey, Seth J, Eaves, Connie, Minden, Mark D, Wang, Jean C Y, Dick, John E, Nislow, Corey, Giaever, Guri, Schimmer, Aaron D

“…Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses…”
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Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation by Xie, Stephanie Z, Kaufmann, Kerstin B, Wang, Weijia, Chan-Seng-Yue, Michelle, Gan, Olga I, Laurenti, Elisa, Garcia-Prat, Laura, Takayanagi, Shin-Ichiro, Ng, Stanley W K, Xu, ChangJiang, Zeng, Andy G X, Jin, Liqing, McLeod, Jessica, Wagenblast, Elvin, Mitchell, Amanda, Kennedy, James A, Liu, Qiang, Boutzen, Héléna, Kleinau, Melissa, Jargstorf, Joseph, Holmes, Gareth, Zhang, Yang, Voisin, Veronique, Bader, Gary D, Wang, Jean C Y, Hannun, Yusuf A, Luberto, Chiara, Schroeder, Timm, Minden, Mark D, Dick, John E

“…Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis, driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC)…”
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SIRPαFc treatment targets human acute myeloid leukemia stem cells by Galkin, Oleksandr, McLeod, Jessica, Kennedy, James A, Jin, Liqing, Mbong, Nathan, Wong, Mark, Uger, Robert A, Minden, Mark D, Danska, Jayne S, Wang, Jean C Y

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Evaluating therapeutic efficacy against cancer stem cells: new challenges posed by a new paradigm by Wang, Jean C Y

“…Current measures of anticancer drug efficacy reflect bulk cell killing and are poorly suited to detect activity against cancer stem cells (CSCs), which sustain…”
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Good cells gone bad: the cellular origins of cancer by Wang, Jean C.Y

“…One issue in human cancer research that remains largely unresolved is the identity of the normal cell type in which tumorigenesis begins. Knowledge of the…”
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Bringing Leukemia Stem Cells into the Clinic by Wang, Jean C Y

“…Outcomes in acute myeloid leukemia (AML) remain poor due to high rates of relapse. Thus, there is an urgent unmet medical need for new therapies that can more…”
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Identification of existing bioactive molecules that target acute myeloid leukemia stem cells by Boileau, Meaghan, Laverdière, Isabelle, Mitchell, Amanda, Ng, Stanley W.K, Wang, Jean C.Y, Minden, Mark D, Dick, John E, Eppert, Kolja

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Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture by Bhatia, M, Bonnet, D, Kapp, U, Wang, J C, Murdoch, B, Dick, J E

“…Ex vivo culture of human hematopoietic cells is a crucial component of many therapeutic applications. Although current culture conditions have been optimized…”
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Tracing the origins of relapse in acute myeloid leukaemia to stem cells by Shlush, Liran I., Mitchell, Amanda, Heisler, Lawrence, Abelson, Sagi, Ng, Stanley W. K., Trotman-Grant, Aaron, Medeiros, Jessie J. F., Rao-Bhatia, Abilasha, Jaciw-Zurakowsky, Ivana, Marke, Rene, McLeod, Jessica L., Doedens, Monica, Bader, Gary, Voisin, Veronique, Xu, ChangJiang, McPherson, John D., Hudson, Thomas J., Wang, Jean C. Y., Minden, Mark D., Dick, John E.

“…Identification of the cell types from which relapse arises in acute myeloid leukaemia, by following leukaemia propagation from patient-derived leukaemia…”
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A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia by Zeng, Andy G. X., Bansal, Suraj, Jin, Liqing, Mitchell, Amanda, Chen, Weihsu Claire, Abbas, Hussein A., Chan-Seng-Yue, Michelle, Voisin, Veronique, van Galen, Peter, Tierens, Anne, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Daver, Naval, Futreal, P. Andrew, Minden, Mark D., Kennedy, James A., Wang, Jean C. Y., Dick, John E.

“…The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising therapies entering clinical translation, yet patient responses remain…”
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Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis by Subedi, Amit, Liu, Qiang, Ayyathan, Dhanoop M., Sharon, David, Cathelin, Severine, Hosseini, Mohsen, Xu, Changjiang, Voisin, Veronique, Bader, Gary D., D’Alessandro, Angelo, Lechman, Eric R., Dick, John E., Minden, Mark D., Wang, Jean C.Y., Chan, Steven M.

“…Current treatments for acute myeloid leukemia (AML) are often ineffective in eliminating leukemic stem cells (LSCs), which perpetuate the disease. Here, we…”
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A 17-gene stemness score for rapid determination of risk in acute leukaemia by Ng, Stanley W. K., Mitchell, Amanda, Kennedy, James A., Chen, Weihsu C., McLeod, Jessica, Ibrahimova, Narmin, Arruda, Andrea, Popescu, Andreea, Gupta, Vikas, Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., Bullinger, Lars, Herold, Tobias, Görlich, Dennis, Büchner, Thomas, Hiddemann, Wolfgang, Berdel, Wolfgang E., Wörmann, Bernhard, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Metzeler, Klaus, Buske, Christian, Löwenberg, Bob, Valk, Peter J. M., Zandstra, Peter W., Minden, Mark D., Dick, John E., Wang, Jean C. Y.

“…A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy…”
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