Search Results - "Wang, Huping"
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Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM
Published in Nature structural & molecular biology (01-12-2016)“…Cryo-EM analyses of yeast TRiC (CCT) reveal conformational changes induced by ATP binding and a staggered mode of nucleotide binding to the different subunits…”
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Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes
Published in Cell (15-10-2020)“…Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational…”
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Yeast Inner-Subunit PA–NZ-1 Labeling Strategy for Accurate Subunit Identification in a Macromolecular Complex through Cryo-EM Analysis
Published in Journal of molecular biology (11-05-2018)“…Cryo-electron microscopy (cryo-EM) has been established as one of the central tools in the structural study of macromolecular complexes. Although intermediate-…”
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The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model
Published in Nature communications (11-08-2021)“…Spreading of aggregate pathology across brain regions acts as a driver of disease progression in Tau-related neurodegeneration, including Alzheimer’s disease…”
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Structure and conformational cycle of a bacteriophage-encoded chaperonin
Published in PloS one (27-04-2020)“…Chaperonins are ubiquitous molecular chaperones found in all domains of life. They form ring-shaped complexes that assist in the folding of substrate proteins…”
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Mechanisms of mitophagy and oxidative stress in cerebral ischemia-reperfusion, vascular dementia, and Alzheimer's disease
Published in Frontiers in molecular neuroscience (07-08-2024)“…Neurological diseases have consistently represented a significant challenge in both clinical treatment and scientific research. As research has progressed, the…”
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Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT
Published in Scientific reports (05-02-2018)“…Unambiguous subunit assignment in a multicomponent complex is critical for thorough understanding of the machinery and its functionality. The eukaryotic group…”
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Matrine alters microRNA expression profiles in SGC-7901 human gastric cancer cells
Published in Oncology reports (01-11-2014)“…Matrine, a major alkaloid extracted from Sophora flavescens, has been reported to possess antitumor properties in several types of cancers, including gastric…”
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Lifelong learning in rural communities in China and its impact on adult subjective well-being
Published in International journal of educational research (2025)“…•The author used the WHO-5 Well-Being Index to measure well-being.•The author compiled and implemented a 6-month program.•Data analysis demonstrated a…”
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Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis
Published in Nature structural & molecular biology (01-11-2021)“…Carboxysomes in cyanobacteria enclose the enzymes Rubisco and carbonic anhydrase to optimize photosynthetic carbon fixation. Understanding carboxysome assembly…”
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Optimization of teaching management in colleges and universities based on dynamic programming
Published in Cluster computing (01-11-2019)“…At present, with the increasingly diversified and complicated teaching management in colleges and universities, the application of computer technology is…”
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Localized solutions to interval linear equations
Published in Journal of computational and applied mathematics (15-01-2013)“…In this paper, we propose a new type of solutions, localized solutions, to interval linear equations Ax=b. The new solutions are based on L-localized solutions…”
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Distribution of CYP2C19 polymorphisms in Mongolian and Han nationals and the choice of specific antiplatelet drugs
Published in International journal of clinical pharmacy (01-08-2017)“…Background Individualized medication reviews may improve our understanding of the distribution of CYP2C19 polymorphisms in ethnic populations. Objective To…”
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A New Secure OpenID Authentication Mechanism Using One-Time Password (OTP)
Published in 2011 7th International Conference on Wireless Communications, Networking and Mobile Computing (01-09-2011)“…Nowadays, OpenID is a popular specification and provided by several large websites. It is decentralized, open standard to authenticate user's identity. We…”
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Conference Proceeding -
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Matrine alters microRNA expression profiles in SGC-7901 human gastric cancer cells
Published in Oncology reports (01-11-2014)“…Matrine, a major alkaloid extracted from Sophora flavescens, has been reported to possess antitumor properties in several types of cancers, including gastric…”
Get full text
Journal Article