Search Results - "Wang, Hong Wei"
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Reconstitution and structure of a plant NLR resistosome conferring immunity
Published in Science (American Association for the Advancement of Science) (05-04-2019)“…Nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen effectors to trigger plant immunity. Biochemical mechanisms underlying plant NLR…”
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Ligand-triggered allosteric ADP release primes a plant NLR complex
Published in Science (American Association for the Advancement of Science) (05-04-2019)“…Pathogen recognition by nucleotide-binding (NB), leucine-rich repeat (LRR) receptors (NLRs) plays roles in plant immunity. The pv. effector AvrAC uridylylates…”
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Structural and biochemical basis for induced self-propagation of NLRC4
Published in Science (American Association for the Advancement of Science) (23-10-2015)“…Responding to stimuli, nucleotide-binding domain and leucine-rich repeat–containing proteins (NLRs) oligomerize into multiprotein complexes, termed…”
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4
Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution
Published in Nature communications (03-06-2019)“…The fast development of single-particle cryogenic electron microscopy (cryo-EM) has made it more feasible to obtain the 3D structure of well-behaved…”
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WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
Published in Nature communications (16-08-2019)“…WHAMM, a member of the Wiskott-Aldrich syndrome protein (WASP) family, is an actin nucleation promoting factor (NPF) that also associates with membranes and…”
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Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin
Published in The EMBO journal (16-08-2021)“…Pangolins have been suggested as potential reservoir of zoonotic viruses, including SARS‐CoV‐2 causing the global COVID‐19 outbreak. Here, we study the binding…”
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How cryo‐electron microscopy and X‐ray crystallography complement each other
Published in Protein science (01-01-2017)“…With the ability to resolve structures of macromolecules at atomic resolution, X‐ray crystallography has been the most powerful tool in modern structural…”
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Belief rule-base inference methodology using the evidential reasoning Approach-RIMER
Published in IEEE transactions on systems, man and cybernetics. Part A, Systems and humans (01-03-2006)“…In this paper, a generic rule-base inference methodology using the evidential reasoning (RIMER) approach is proposed. Existing knowledge-base structures are…”
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9
NKG2A is a NK cell exhaustion checkpoint for HCV persistence
Published in Nature communications (03-04-2019)“…Exhaustion of cytotoxic effector natural killer (NK) and CD8 + T cells have important functions in the establishment of persistent viral infections, but how…”
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A Low-Profile Varactor-Tunable Bandpass Frequency Selective Surface With Angular Stability Property
Published in IEEE transactions on electromagnetic compatibility (01-02-2024)“…A low-profile varactor-tunable bandpass frequency selective surface (FSS) with angular stability is presented in this article. The FSS comprises two metallic…”
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SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
Published in Science (American Association for the Advancement of Science) (16-03-2012)“…Neurotransmitters are released through nascent fusion pores, which ordinarily dilate after bilayer fusion, preventing consistent biochemical studies. We used…”
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Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange
Published in Nature structural & molecular biology (01-01-2017)“…Cryo-EM analysis captures three states of the human Rad51 recombinase and visualizes structures of presynaptic and postsynaptic filaments as well as a synaptic…”
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13
Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells
Published in Nature communications (27-10-2021)“…Molecular glues are a class of small molecular drugs that mediate protein-protein interactions, that induce either the degradation or stabilization of target…”
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Structural basis for the modular recognition of single-stranded RNA by PPR proteins
Published in Nature (London) (05-12-2013)“…Although the roles of pentatricopeptide repeat (PPR) proteins in RNA metabolism are well characterised, the mechanism by which they recognise specific…”
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Impact of the COVID-19 lockdown on roadside traffic-related air pollution in Shanghai, China
Published in Building and environment (01-05-2021)“…The outbreak of COVID-19 has significantly inhibited global economic growth and impacted the environment. Some evidence suggests that lockdown strategies have…”
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Cryo-EM structure of the exocyst complex
Published in Nature structural & molecular biology (01-02-2018)“…The exocyst is an evolutionarily conserved octameric protein complex that mediates the tethering of post-Golgi secretory vesicles to the plasma membrane during…”
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A similarity-conformity-based clustering and decentralized feedback mechanism to manage incompatible decision-makers in large-scale group decision-making
Published in Expert systems with applications (15-07-2024)“…This study proposes a similarity-conformity-based clustering and decentralized feedback mechanism to manage incompatible decision-makers (DMs) in the…”
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Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine
Published in Nature chemical biology (01-05-2020)“…The α 2 adrenergic receptors (α 2 ARs) are G protein-coupled receptors (GPCRs) that respond to adrenaline and noradrenaline and couple to the Gi/o family of G…”
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Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy
Published in Nature communications (28-01-2020)“…The fast development of high-resolution electron microscopy (EM) demands a background-noise-free substrate to support the specimens, where atomically thin…”
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FtsZ Protofilaments Use a Hinge-Opening Mechanism for Constrictive Force Generation
Published in Science (26-07-2013)“…The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a structure at the division site termed the "Z ring". During…”
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