Search Results - "Wang, Gavin"

A Blind Search for Transit Depth Variability with TESS by Wang, Gavin, Espinoza, Néstor

“…Abstract The phenomenon of transit depth variability offers a pathway through which processes such as exoplanet atmospheric activity and orbital dynamics can…”
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Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage by Luo, Hongmei, Yang, Aimin, Schulte, Bradley A, Wargovich, Michael J, Wang, Gavin Y

“…Resveratrol (RV) is a natural component of red wine and grapes that has been shown to be a potential chemopreventive and anticancer agent. However, the…”
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BAY 11-7082 inhibits the secretion of interleukin-6 by senescent human microglia by Cook, Maxwell, Lin, Houmin, Mishra, Sandeep K., Wang, Gavin Y.

“…The accumulation of senescent cells in aged tissues has been implicated in a variety of age-related diseases, including cancer and neurodegenerative disorders…”
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Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization by Wang, Yanzhong, Zeng, Jin, Wu, Weiping, Xie, Shuduo, Yu, Haitao, Li, Guoli, Zhu, Tao, Li, Fengying, Lu, Jie, Wang, Gavin Y, Xie, Xinyou, Zhang, Jun

“…Nicotinamide N-methyltransferase (NNMT) is overexpressed in various human tumors and involved in the development and progression of several carcinomas. In…”
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Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair by Qin, Shenghui, He, Xiaoyuan, Lin, Houmin, Schulte, Bradley A., Zhao, Mingfeng, Tew, Kenneth D., Wang, Gavin Y.

“…Radiation is widely used for cancer treatment but the radioresistance properties of cancer stem cells (CSCs) pose a significant challenge to the success of…”
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Oxidative stress induces senescence in breast cancer stem cells by Zhong, Guangxian, Qin, Shenghui, Townsend, Danyelle, Schulte, Bradley A., Tew, Kenneth D., Wang, Gavin Y.

“…Cancer stem cells (CSCs) have been shown to be resistant to current anticancer therapies and the induction of oxidative stress is an important mechanism of…”
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MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer by Yang, Aimin, Qin, Shenghui, Schulte, Bradley A, Ethier, Stephen P, Tew, Kenneth D, Wang, Gavin Y

“…There is mounting evidence that cancer stem-like cells (CSC) are selectively enriched in residual tumors after anticancer therapies, which may account for…”
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NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity by Wang, Yanzhong, Zhou, Xi, Lei, Yinjiao, Chu, Yadong, Yu, Xingtong, Tong, Qingchao, Zhu, Tao, Yu, Haitao, Fang, Sining, Li, Guoli, Wang, Linbo, Wang, Gavin Y., Xie, Xinyou, Zhang, Jun

“…Elucidating the mechanism for high metastasis capacity of triple negative breast cancers (TNBC) is crucial to improve treatment outcomes of TNBC. We have…”
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A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities by Bartolini, Desirée, Wang, Yanzhong, Zhang, Jie, Giustarini, Daniela, Rossi, Ranieri, Wang, Gavin Y, Torquato, Pierangelo, Townsend, Danyelle M, Tew, Kenneth D, Galli, Francesco

“…2,2'-diselenyldibenzoic acid (DSBA) is a chemical probe produced to explore the pharmacological properties of diphenyldiselenide-derived agents with…”
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p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia by Lin, Houmin, Dixon, Steven Grant, Hu, Wei, Hamlett, Eric D., Jin, Junfei, Ergul, Adviye, Wang, Gavin Y.

“…The accumulation of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer’s disease (AD) pathology. Microglial activation-mediated…”
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Nrf2‐modulation by seleno‐hormetic agents and its potential for radiation protection by Bartolini, Desirée, Tew, Kenneth D., Marinelli, Rita, Galli, Francesco, Wang, Gavin Y.

“…The trace element selenium (Se) is an essential component of selenoproteins and plays a critical role in redox signaling via regulating the activity of…”
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Role of senescence induction in cancer treatment by Qin, Shenghui, Schulte, Bradley A, Wang, Gavin Y

“…Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere…”
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MiR-34a modulates ionizing radiation-induced senescence in lung cancer cells by He, Xiaoyuan, Yang, Aimin, McDonald, Daniel G, Riemer, Ellen C, Vanek, Kenneth N, Schulte, Bradley A, Wang, Gavin Y

“…MicroRNAs (miRNAs) are a new class of gene expression regulators that have been implicated in tumorigenesis and modulation of the responses to cancer treatment…”
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Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 by Zhang, Leilei, Zhang, Jie, Ye, Zhiwei, Manevich, Yefim, Ball, Lauren E, Bethard, Jennifer R, Jiang, Yu-Lin, Broome, Ann-Marie, Dalton, Annamarie C, Wang, Gavin Y, Townsend, Danyelle M, Tew, Kenneth D

“…ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its…”
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Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells by LUO, HONGMEI, WANG, LU, SCHULTE, BRADLEY A, YANG, AIMIN, TANG, SHENGSONG, WANG, GAVIN Y

“…Radiotherapy is used in >50% of patients during the course of cancer treatment both as a curative modality and for palliation. However, radioresistance is a…”
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Dynamical Architectures of S-type Transiting Planets in Binaries. I. Target Selection Using Hipparcos and Gaia Proper Motion Anomalies by Zhang 张, Jingwen 婧雯, Weiss, Lauren M., Huber, Daniel, Jensen, Eric L. N., Brandt, Timothy D., Collins, Karen, Conti, Dennis M., Isaacson, Howard, Lewin, Pablo, Marino, Giuseppe, Massey, Bob, Murgas, Felipe, Palle, Enric, Radford, Don J., Relles, Howard M., Srdoc, Gregor, Stockdale, Chris, Tan, Thiam-Guan, Wang, Gavin

“…Abstract The effect of stellar multiplicity on planetary architecture and orbital dynamics provides an important context for exoplanet demographics. We present…”
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Catalase inhibits ionizing radiation-induced apoptosis in hematopoietic stem and progenitor cells by Xiao, Xia, Luo, Hongmei, Vanek, Kenneth N, LaRue, Amanda C, Schulte, Bradley A, Wang, Gavin Y

“…Hematologic toxicity is a major cause of mortality in radiation emergency scenarios and a primary side effect concern in patients undergoing…”
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Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence by Luo, Hongmei, Yount, Caroline, Lang, Hainan, Yang, Aimin, Riemer, Ellen C, Lyons, Katherine, Vanek, Kenneth N, Silvestri, Gerard A, Schulte, Bradley A, Wang, Gavin Y

“…Abstract Radiotherapy is routinely used for the treatment of lung cancer. However, the mechanisms underlying ionizing radiation (IR)-induced senescence and its…”
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Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis by Hu, Tianxiang, Cheng, Bo, Matsunaga, Atsuko, Zhang, Ting, Lu, Xiaocui, Fang, Hui, Mori, Stephanie F, Fang, Xuexiu, Wang, Gavin, Xu, Hongyan, Shi, Huidong, Cowell, John K

“…Leukemias driven by activated, chimeric FGFR1 kinases typically progress to AML which have poor prognosis. Mouse models of this syndrome allow detailed…”
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Targeting MYC for triple-negative breast cancer treatment by Klauber-DeMore, Nancy, Schulte, Bradley A, Wang, Gavin Y

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